Interactions on record — worth a quick check against your medications. Based on 4 of 8 ingredients. Check your meds →
Dietary supplement

Gas Stop Enzyme Formula Ingredients & Drug Interactions

by Renew Life

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Gas Stop Enzyme Formula is a dietary supplement by Renew Life with 8 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 740 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fennel. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Gas Stop Enzyme Formula by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “SmartZyme Blend” is a proprietary blend — the label gives one combined amount (680 mg) without saying how much of each component you get.

Gas Stop Enzyme Formula contains 8 ingredients: the digestive enzymes amylase, protease, lipase, cellulase, and alpha-galactosidase, plus invertase, fennel, and phytase. These enzymes are designed to break down different types of food — carbohydrates, proteins, fats, and fiber — to help reduce gas and bloating.

Fennel is an herb traditionally used to support digestion. The capsule itself is an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Helps prevent occasional gas and bloating.
  • We looked for evidence on: Flatulence, Bloating, Indigestion, Digestive discomfort.
  • The closest evidence on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Flatulence (Natural Medicines).

The digestive enzymes in this product (protease, lipase, and phytase) have not been rated for effectiveness in our data. Fennel is considered possibly effective for period pain (dysmenorrhea), but evidence for its use in digestive complaints or gas is not established in the data we hold.

For most of the enzyme ingredients, the evidence to support their role in gas relief specifically is insufficient.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Fennel Phytase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease, lipase, and phytase are generally well tolerated, though they may cause digestive upset in some people and rarely allergic reactions. Fennel is well tolerated as a food, but concentrated supplements carry more caution.

Both protease and phytase have rare reports of allergic reactions in people exposed to airborne powder occupationally. For pregnancy, the safety data advises against medicinal or concentrated fennel due to limited data and its hormone-like effects.

Protease safety has not been established in pregnancy, so it is best avoided unless prescribed. Lipase and phytase have insufficient safety data in pregnancy — talk with your doctor before use.

Breastfeeding safety is similarly uncertain for all these ingredients; check with your healthcare provider first.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Fennel Phytase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Fennel.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 741 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Gas Stop Enzyme Formula, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (moderate risk of increased bleeding), birth control pills or estrogen replacement therapy (moderate risk of reduced effectiveness), the antibiotic ciprofloxacin/Cipro (moderate risk of reduced antibiotic effect), medications metabolized by CYP3A4 enzymes in the liver (moderate risk of raised drug levels), or tamoxifen for breast cancer (moderate risk of reduced cancer-drug effect). All of these concerns come from the fennel ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed to ease gas and bloating through digestive enzymes. If you take blood thinners, birth control, estrogen therapy, ciprofloxacin, tamoxifen, or any regular medication, check your exact drugs with your pharmacist or doctor before starting — fennel interactions are a real concern.

If you're pregnant or breastfeeding, the safety data are too limited; talk it over with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gas Stop Enzyme Formula, straight from the product label.

Brand Renew Life
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 250889
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gas Stop Enzyme Formula by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Cellulase0 NP--
Invertase0 NP--
Fennel0 NP--
SmartZyme Blend680 mg--
Alpha-Galactosidase0 NP--
Phytase0 NP--

Other ingredients: Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

- Helps prevent ocassional gas and bloating - Helps digest beans and gas-forming foods

Dairy free

Quality, purity, and potency guaranteed through expiration.

Manufactured in USA of global ingredients

Listen to your gut...you'll be glad you did. At Renew Life, we're gut wellness pioneers with double decades of experience and innovation on our side to help keep your gut healthy and help you comfortably enjoy the foods you love.

Renew Life plant-based enzymes work in harmony with your digestive system to reduce occasional digestive discomforts and unlock the nutrient goodness found in your food. Helping you feel lighter, brighter and more energized to take on the day.

FDA Statement of Identity

Enzyme Supplement

Suggested/Recommended/Usage/Directions

Directions: Take two (2) capsules before a meal containing problem food(s).

Precautions

Contains: Wheat and soy traces from fermentation media.

Keep out of reach of children.

Consult your physician prior to using this or any product if you are pregnant, nursing, taking any medication, or have a medical condition.

Warning: This product can expose you to chemicals including lead, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.

Storage

Store at 77 degrees F (25 degrees C) or below.

Brand IP Statement(s)

Copyright 2018 Patents: www.renewlife.com/patents

General Statements

Visit RenewLife.com for help finding the right product for you. Did you know taking an enzyme before each meal can improve your digestion? Many processed and cooked foods often lack the digestive enzymes found in raw foods, so your body may have to work harder to break down and absorb nutrients. This can cause occasional gas, bloating and indigestion.

Formula

Plant-based enzymes for relief of occasional gas Contains soothing fennel seed to help relax the digestive tract

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Gas Stop Enzyme Formula by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Gas Stop Enzyme Formula by Renew Life

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

SmartZyme Blend

680 mg per serving

Other (inactive) ingredients: Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gas Stop Enzyme Formula by Renew Life Drug Interactions

Want to check YOUR meds against Gas Stop Enzyme Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
740Drugs
740 Moderate

Ingredients driving the most interactions

Fennel 740

Each ingredient & the kinds of drugs it affects

For each ingredient in Gas Stop Enzyme Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Gas Stop Enzyme Formula, from the product label.

Renew Life

Name
Renew Life Formulas, Inc.
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

Gas Stop Enzyme Formula by Renew Life: Common Questions

Does Gas Stop Enzyme Formula by Renew Life interact with any medications?
Yes. Based on its ingredients, Gas Stop Enzyme Formula has a known interaction with 740 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gas Stop Enzyme Formula contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the digestive enzymes in this formula supposed to do?
They break down different types of food — proteins, fats, carbohydrates, and fiber — so less undigested material reaches your colon and causes gas. Amylase breaks down carbs, protease handles proteins, lipase tackles fats, and the others help with specific sugars and fiber.
Is fennel safe to use while I'm pregnant or breastfeeding?
The safety data advise against medicinal or concentrated fennel in pregnancy due to limited data and its hormone-like effects. For breastfeeding, food amounts are likely fine, but medicinal doses and fennel essential oil are not well studied. Talk with your doctor or pharmacist before taking this product if you're pregnant or breastfeeding.
Can I take this if I'm on birth control?
Fennel in this formula may theoretically reduce how well birth control works because of its estrogenic compounds. It's a moderate-severity concern, so check with your doctor or pharmacist about whether this product is right for you.
Is there any evidence this actually works for gas?
The evidence to support these digestive enzymes for gas relief is not established in the data we hold. Fennel is possibly effective for period pain, but not for gas. Your best bet is to run it by your doctor to see if it fits your situation.
What are the most common side effects?
These enzymes are generally well tolerated, but some people report digestive upset. Fennel may cause stomach discomfort, sensitivity to sunlight, or allergic reactions in sensitive people. Serious side effects are rare.
I take a blood thinner — is this product okay?
No — fennel in this formula may theoretically increase your bleeding risk when combined with blood thinners. This is a moderate-severity concern, so do not start this product without talking to your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gas Stop Enzyme Formula is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gas Stop Enzyme Formula label
Sources

Sources & How We Checked

Gas Stop Enzyme Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
  4. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  5. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  6. Rosti L, Nardini A, Bettinelli ME, Rosti D. Toxic effects of a herbal tea mixture in two newborns. Acta Paediatrica 1994;83:683. PubMed
  7. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  8. Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol.Res 2007;56(3):254-260. PubMed
  9. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
  10. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  11. Subehan, Zaidi, S. F., Kadota, S., and Tezuka, Y. Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. J Agric.Food Chem. 12-12-2007;55(25):101 PubMed
  12. LEVY, S. B. Bronchial asthma due to ingestion of fennel and fennel seed. Ann.Allergy 1948;6(4):415.
  13. Ottolenghi, A., De Chiara, A., Arrigoni, S., Terracciano, L., and De Amici, M. [Diagnosis of food allergy caused by fruit and vegetables in children with atopic dermatitis]. Pediatr Med Chir 1995;17(6):525-530.
  14. Trabace L, Tucci P, Ciuffreda L, et al. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. J Ethnopharmacol. 2015;174:396-402. PubMed
  15. Denaxa D, Arkwright PD. Fennel as a cause of immediate hypersensitivity to toothpaste. Ann Allergy Asthma Immunol. 2020;125(1):99-100. PubMed
  16. Lee HW, Ang L, Lee MS, Alimoradi Z, Kim E. Fennel for reducing pain in primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Nutrients 2020;12(11):3438. PubMed
  17. Mathew T, John SK, Javali M, Vasireddy M, Nadig R, Sarma GRK. Substance use related cluster headache: A case series. Headache 2022;62(7):908-910. PubMed

See these in context on the Fennel monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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