Glycine 1000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Glycine 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Glycine 1000 mg is a dietary supplement by Double Wood Supplements with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Glycine 1000 mg by Double Wood Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine 1000 mg by Double Wood Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Glycine 1000 mg by Double Wood Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-glycine at 1000 mg per capsule. Glycine is a simple amino acid your body naturally makes and uses in various roles, including supporting muscle and nervous system function.
The capsule also contains inactive ingredients (gelatin, cellulose, silicon dioxide, and magnesium stearate) that help deliver the glycine.
Does it work?
Not established
Glycine is possibly effective for schizophrenia — though it's important to note the one interaction we found suggests adding it to clozapine therapy may worsen symptoms rather than help. For other conditions listed (3-phosphoglycerate dehydrogenase deficiency, ADHD, benign prostatic hyperplasia, and cystic fibrosis), the evidence isn't established in the data we hold.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Mild sedation, irritability, insomnia, fatigue, headache, and memory impairment have been reported rarely, as have soft stools, nausea, vomiting, and upper digestive discomfort — all of which resolve quickly if you stop taking it.
We don't have reliable safety data for use in pregnancy or while breastfeeding, so it's best to talk with your doctor or pharmacist for personalized advice if either applies to you.
Meds to double-check
Moderate interaction found
Before you start, double-check if you take clozapine (Clozaril) — a Moderate interaction means this supplement may reduce its effectiveness and may worsen schizophrenia symptoms. Talk to your doctor or pharmacist to be sure it's safe to combine.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Glycine may be worth considering if you're interested in amino acid supplementation and don't take clozapine. If you do take clozapine or any other medications, check with your doctor or pharmacist before starting — they'll help you decide if it's right for you and can watch for any changes in how you feel.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Glycine 1000 mg, straight from the product label.
| Brand | Double Wood Supplements |
|---|---|
| Barcode (UPC) | 859793007693 |
| Net contents | 300 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2021 |
| DSLD ID | 241803 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Glycine 1000 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Glycine | 1000 mg | -- |
Other ingredients: Gelatin, Cellulose, Silicon Dioxide, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Product Information: Glycine is an amino acid and neurotransmitter which plays a variety of roles in the brain. Glycine is the most commonly used as a supplement for its ability to support healthy sleep. It has also been shown to support liver, kidney, and cognitive health.
1000 mg per serving
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, 2-4 capsules (1000-2000 mg) per day on an empty stomach. If using to support sleep quality, use around 1-2 hours before bed. Do not exceed 10 capsules in one day.
Storage
Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.
Formulation
Supports healthy sleep quality Supports liver and kidney health
FDA Statement of Identity
Dietary Supplement
Precautions
Warning: Consult your physician before use.
Do not use Glycine if you are pregnant, nursing, or are under 18 ears of age.
Discontinue use and consult your doctor immediately if any adverse reactions occur.
Do not use Glycine and operate heavy machinery until you know how it affects you.
Keep out of reach of children.
Do not exceed 10 capsules per day.
FDA Disclaimer Statement
These statements haven not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Glycine 1000 mg by Double Wood Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Glycine 1000 mg by Double Wood Supplements
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.
L-Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
L-Glycine monograph & interactionsOther (inactive) ingredients: Gelatin, Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Glycine 1000 mg by Double Wood Supplements Drug Interactions
HelloPharmacist Interaction Report
Glycine 1000 mg by Double Wood Supplements has one documented interaction: it may reduce how well clozapine (Clozaril), an antipsychotic medication for schizophrenia, works.
A small clinical study showed that adding glycine to clozapine therapy actually worsened schizophrenia symptoms compared to clozapine alone, though why this happens isn't fully understood.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 1 individual medication.
If you take clozapine, check with your doctor or pharmacist before starting this supplement. You'll want to make sure they know you're considering it and can monitor you for any changes in your symptoms.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Glycine 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Glycine 1000 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Glycine 1000 mg interact with drugs. Each result below shows which ingredient is responsible. L-Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with Glycine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full L-glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Glycine 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Glycine 1000 mg, from the product label.
Double Wood Supplements
See all Double Wood Supplements products- Name
- Double Wood LLC
- Street Address
- 3510 Scotts Ln Ste 219
- City
- Philadelphia
- State
- PA
- ZipCode
- 19129-1573
- Web Address
- www.doublewoodsupplements.com
Glycine 1000 mg by Double Wood Supplements: Common Questions
Does Glycine 1000 mg by Double Wood Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does glycine actually do in the body?
Can I use this if I take clozapine for schizophrenia?
What side effects should I watch for?
Is it safe to take while pregnant or breastfeeding?
How long can I take this supplement?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Glycine 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Glycine 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Glycine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC