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Dietary supplement

Serrapeptase 240,000 SPU Ingredients & Drug Interactions

by Double Wood Supplements

Serrapeptase 240,000 SPU label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase 240,000 SPU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase 240,000 SPU is a dietary supplement by Double Wood Supplements with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase 240,000 SPU by Double Wood Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase 240,000 SPU by Double Wood Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Serrapeptase 240,000 SPU by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: serrapeptase, a proteolytic enzyme — a protein that breaks down other proteins. The capsule itself is made from vegetable material and contains rice flour, magnesium stearate, and silicon dioxide as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports nasal and respiratory health.
  • We looked for evidence on: Asthma, Bronchiectasis, Chronic bronchitis, Laryngitis, Otitis media, Pharyngitis — and 4 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Asthma, Otitis media, Pharyngitis, Rhinosinusitis, and more.

The evidence isn't established in the data we hold. Serrapeptase has been studied for chronic bronchitis, asthma, atherosclerosis (clogged arteries), back pain, and osteoporosis, but we have insufficient reliable evidence to rate it for any of these conditions.

If you're considering it for a specific health concern, that's worth discussing with your pharmacist or doctor.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in the short term, though long-term safety hasn't been well studied. The most common side effects reported are stomach pain, general digestive upset, and nausea — though research suggests these occur at about the same rate as placebo.

A rare serious side effect (bullous pemphigoid, a skin condition) has been reported. The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know it's safe.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs — such as warfarin, dabigatran, aspirin, clopidogrel, or similar medications — check your exact medication list with the search tool on this page before adding serrapeptase. The combination carries a Moderate risk of increased bleeding.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners or antiplatelet drugs, check with your pharmacist before starting serrapeptase — the combination could raise your bleeding risk. It's generally well tolerated short-term, but long-term use hasn't been studied much.

Avoid it if you're pregnant or breastfeeding, and let your healthcare provider know if you experience stomach pain or nausea.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase 240,000 SPU, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) 850033272130
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 315695
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase 240,000 SPU by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
850033272130
IngredientAmount% DV
Serrapeptase0 NP--

Other ingredients: Rice Flour, Vegetable capsule, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Serrapeptase is a proteolytics enzyme native to the digestive tract of silkworms. Many individuals take it for nasal and respiratory health and some evidence suggests may help thin mucus.

Serrapeptase 240,000 SPU Per serving

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take1 serving per day. (2 capsules) For best results take 30 minutes before a meal or 2 hours after a meal.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Supports Nasal and Respiratory Health

FDA Statement of Identity

Dietary Supplement

Precautions

Allergen Warning: Contains soy and milk.

Warning: Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Discontinue use and consult your doctor immediately if any adverse reactions occur. Do not use Serrapeptase and operate heavy machinery until you know how it affects you.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

General Statements

SPU Serratiopeptidase Units

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase 240,000 SPU by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase 240,000 SPU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase 240,000 SPU by Double Wood Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
0 NP per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Rice Flour, Vegetable capsule, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase 240,000 SPU by Double Wood Supplements Drug Interactions

Want to check YOUR meds against Serrapeptase 240,000 SPU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase 240,000 SPU interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase 240,000 SPU interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase 240,000 SPU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase 240,000 SPU, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
3510 Scotts Ln Ste 219
City
Philadelphia
State
PA
ZipCode
19129
Web Address
www.doublewoodsupplements.com
Pharmacist Counseling Corner

Serrapeptase 240,000 SPU by Double Wood Supplements: Common Questions

Does Serrapeptase 240,000 SPU by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, Serrapeptase 240,000 SPU has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase 240,000 SPU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is serrapeptase?
Serrapeptase is a proteolytic enzyme — a protein that breaks down other proteins. In test-tube studies, it shows fibrinolytic activity, meaning it can break down fibrin, a protein involved in blood clotting.
Does serrapeptase really work?
We have insufficient reliable evidence to rate serrapeptase for the conditions it's been studied in — chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis. That means the current evidence isn't strong enough to say whether it works for these purposes.
What side effects should I watch for?
The most common side effects are stomach pain, general digestive upset, and nausea, though research suggests they occur about as often as placebo. A rare serious side effect called bullous pemphigoid (a skin condition) has been reported. Stop and talk to your pharmacist if you experience persistent stomach pain.
Is it safe to take while pregnant or breastfeeding?
No. The safety data advises against serrapeptase during pregnancy and while breastfeeding because there isn't enough information to know it's safe in these situations. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.
How long can I safely take this?
Serrapeptase is generally well tolerated in the short term, but long-term safety hasn't been well studied. If you're thinking about taking it long-term, that's a good conversation to have with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase 240,000 SPU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase 240,000 SPU label
Go deeper

The Full Monographs Behind Serrapeptase 240,000 SPU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase 240,000 SPU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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