Glycine 1000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Glycine 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Glycine 1000 mg is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Glycine 1000 mg by Life Extension
Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine 1000 mg by Life Extension — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Glycine 1000 mg by Life Extension
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: glycine, an amino acid (a building block your body uses to make proteins and other compounds). Life Extension includes cellulose and ascorbyl palmitate as inactive ingredients—a capsule filler and a form of vitamin C used as a preservative.
Does it work?
Moderate evidence
Glycine is possibly effective for schizophrenia according to clinical evidence. However, the data we hold show insufficient reliable evidence to rate it for 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, attention deficit-hyperactivity disorder (ADHD), benign prostatic hyperplasia (an enlarged prostate, or BPH), and cystic fibrosis.
If you're considering it for any of those conditions, talk with your doctor about what the current science supports.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Rarely, people have reported mild sedation, irritability, insomnia, fatigue, memory problems, headache, and sensory changes—though we can't be sure glycine caused them.
Soft stools, nausea, vomiting, upper stomach discomfort, and dry mouth have also been reported rarely. These side effects resolve quickly if you stop taking it.
There isn't enough reliable safety data to know how safe glycine is during pregnancy, so it's best avoided unless your doctor approves. The same goes for breastfeeding—not enough data exists, so caution is advised and you should talk with your doctor.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril), an antipsychotic medication, check with your doctor before adding this supplement—glycine may decrease its effectiveness. No other interactions are documented for the ingredients we could check in our data.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Glycine may help with schizophrenia symptoms, though the evidence is limited. If you take clozapine, you should check with your doctor first—this supplement may interfere with how well it works.
For other uses or medications, run your exact drugs through the tool on this page. Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or taking prescription medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Glycine 1000 mg, straight from the product label.
| Brand | Life Extension |
|---|---|
| Barcode (UPC) | 737870166917 |
| Net contents | 100 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 328470 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Glycine 1000 mg by Life Extension, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Glycine | 1000 mg | -- |
Other ingredients: Cellulose, Ascorbyl Palmitate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Scan for product info
Precautions
Read the entire label and follow the directions carefully prior to use.
Warnings: Keep out of reach of children.
Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
To report a serious adverse event or obtain product information, contact 1-866-280-2852.
Suggested/Recommended/Usage/Directions
Directions: Take one (1) capsule one to three times daily, on an empty stomach at bedtime, or as recommended by a healthcare practitioner.
Storage
Store tightly closed in a cool, dry place.
Formulation
Gluten Free Non GMO Le Certified
Seals/Symbols
Non GMO Le Certified
Formula
Amino acid for healthy sleep
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Glycine 1000 mg by Life Extension label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Glycine 1000 mg by Life Extension
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsOther (inactive) ingredients: Cellulose, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.
Glycine 1000 mg by Life Extension Drug Interactions
HelloPharmacist Interaction Report
Life Extension Glycine 1000 mg has one documented interaction with a medication.
Glycine may decrease how well clozapine (Clozaril), an antipsychotic used for schizophrenia, works. A small clinical study found that adding glycine to clozapine therapy actually worsened schizophrenia symptoms compared to clozapine alone, though we don't yet understand exactly why this happens.
Read the full breakdown — every affected drug type, severity by severity
Additionally, no interactions are documented in our data for any other medications. We could not check for interactions beyond clozapine because our monograph on glycine holds data only for this one drug.
If you take clozapine, don't start this supplement without talking to your doctor first. If you take other medications, use the search tool on this page to check your exact drugs.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Glycine 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Glycine 1000 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Glycine 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with Glycine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Glycine 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Glycine 1000 mg, from the product label.
Life Extension
See all Life Extension products- Name
- Quality Supplements and Vitamins, Inc.
- City
- Ft. Lauderdale
- State
- FL
- ZipCode
- 33309
- Phone Number
- 1-866-280-2852
- Web Address
- LifeExtension.com
Glycine 1000 mg by Life Extension: Common Questions
Does Glycine 1000 mg by Life Extension interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does glycine actually help with schizophrenia?
What side effects might I see?
Can I take this while pregnant or breastfeeding?
Is this safe to take long-term?
What exactly is glycine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Glycine 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Glycine 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Glycine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC