Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Optimized Broccoli and Cruciferous Blend Ingredients & Drug Interactions

by Life Extension

Optimized Broccoli and Cruciferous Blend label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Optimized Broccoli and Cruciferous Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Optimized Broccoli and Cruciferous Blend is a dietary supplement by Life Extension with 6 active ingredients. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 500 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rosemary Leaf Extract, Cabbage Leaf Extract, 3,3'-Diindolymethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Optimized Broccoli and Cruciferous Blend by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Optimized Broccoli and Cruciferous Blend by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Optimized Broccoli and Cruciferous Blend by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 6 active ingredients: two broccoli extracts (TrueBroc and BroccoVital), diindolylmethane (a compound from broccoli), watercress whole herb extract, rosemary leaf extract, and cabbage leaf extract. These are all cruciferous vegetables or their extracts, chosen for their phytonutrient profiles.

The tablet also contains inactive ingredients—microcrystalline cellulose, methacrylic acid copolymer, hypromellose, propylene glycol, croscarmellose sodium, stearic acid, and silica—which are standard binders, coatings, and flow agents used in supplement manufacturing.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Memory — rated "Possibly Effective" (Rosemary) (Natural Medicines).
  • On file: Breast engorgement — rated "Possibly Effective" (Cabbage) (Natural Medicines).
  • On file: Colorectal cancer — rated "Possibly Effective" (Broccoli) (Natural Medicines).

The evidence for these ingredients is mixed and mostly limited. Broccoli (both forms) is possibly effective for colorectal cancer prevention, but evidence for bladder, breast, gastric cancers and fibromyalgia is insufficient.

Rosemary leaf extract is possibly effective for memory support, though evidence for age-related cognitive decline, hair loss, and fatty liver disease is insufficient. Cabbage leaf extract is possibly effective for breast engorgement; evidence for bladder, colorectal, and gastric cancer is insufficient.

For diindolylmethane, watercress, and the other proposed uses, the evidence we hold is insufficient or not established. If cancer prevention or cognitive support is your goal, talk with your doctor about whether this product fits your health plan.

The evidence, ingredient by ingredient Broccoli Diindolylmethane Watercress Rosemary Cabbage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli and cabbage are generally well tolerated as foods; concentrated supplements are less studied, and the product's safety notes flag caution with concentrated extracts. The main oral adverse effects reported are loose stools, diarrhea, abdominal pain, and cramping—especially at high doses.

Diindolylmethane is generally well tolerated short-term, but long-term safety isn't established; most common side effects are diarrhea, gas, headache, nausea, rash, and vomiting. A rare serious effect (DRESS syndrome) has been reported.

Watercress, rosemary, and cabbage are safe in normal food amounts but have limited data at medicinal doses. Raw, wild watercress carries a parasitic risk (fascioliasis), though the standardized extract studied showed no liver toxicity.

Rosemary can cause photosensitivity, allergic contact dermatitis, and occupational asthma in sensitive individuals. Cabbage and broccoli may trigger allergic reactions in people with Brassicaceae family vegetable allergies.

Pregnancy data: broccoli and diindolylmethane are rated likely safe in pregnancy; no data is on file for watercress, rosemary, or cabbage during pregnancy or breastfeeding—talk to your doctor for personalized guidance.

Side effects, ingredient by ingredient Broccoli Diindolylmethane Watercress Rosemary Cabbage

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Rosemary, Cabbage, Watercress, Diindolylmethane, Broccoli.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 500 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take any of the following: lithium (major risk of toxicity), warfarin or other blood thinners, diabetes medications, antiplatelet drugs (like clopidogrel), muscle relaxers (especially chlorzoxazone), sedatives (especially oxazepam), acetaminophen, aspirin or salicylate-containing drugs, estrogen-based medications, water pills (diuretics), or any drug metabolized by CYP1A2 or CYP2A6 enzymes—these include certain antidepressants, some cancer drugs, and others.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This blend is a concentrated cruciferous vegetable supplement best suited for people interested in plant-based nutrition without medication conflicts. If you take lithium, warfarin, diabetes drugs, blood thinners, aspirin, acetaminophen, oxazepam, or chlorzoxazone, check with your pharmacist first—the interactions here are real and can affect how well your medications work.

Even if you're not on medications, loose stools and cramping are possible, especially at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Optimized Broccoli and Cruciferous Blend, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870236832
Net contents 30 Enteric Coated Vegetarian Tablet(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 328610
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Optimized Broccoli and Cruciferous Blend by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Enteric Coated Vegetarian Tablet(s)
Maximum serving Sizes:
1 Enteric Coated Vegetarian Tablet(s)
Servings per container
30
UPC/BARCODE
737870236832
IngredientAmount% DV
TrueBroc300 mg--
3,3'-Diindolymethane100 mg--
BroccoVital Myrosinase Broccoli extract75 mg--
Watercress Whole Herb Extract50 mg--
Rosemary Leaf Extract50 mg--
Cabbage Leaf Extract25 mg--

Other ingredients: Microcrystalline Cellulose, Methacrylic Acid Copolymer Dispersion NF, Hypromellose, Propylene Glycol, Croscarmellose Sodium, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Precautions

Read the entire label and follow the directions carefully prior to use.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) tablet daily, or as recommended by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Brand IP Statement(s)

TrueBroc produced under US patents 5,725,895; 5,968,505; 5,968,567; 6,177,122; and 6,242,018 licensed from Brassica Protection Products LLC; TrueBroc is a trademark of Brassica Protection Products LLC. BroccoVital Myrosinase is a registered trademark of Berg Imports, LLC.

Formulation

Gluten free Non GMO LE Certified

Dual layered bio-active formula

Seals/Symbols

Non GMO LE Certified

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Optimized Broccoli and Cruciferous Blend by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Optimized Broccoli and Cruciferous Blend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Optimized Broccoli and Cruciferous Blend by Life Extension

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Enteric Coated Vegetarian Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

TrueBroc

Interacts with
187 drugs
300 mg per serving Form: Broccoli Seed Extract

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

TrueBroc monograph & interactions

3,3'-Diindolymethane

Interacts with
269 drugs
100 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

3,3'-Diindolymethane monograph & interactions

BroccoVital Myrosinase Broccoli extract

Interacts with
187 drugs
75 mg per serving Form: Myrosinase

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

BroccoVital Myrosinase Broccoli extract monograph & interactions

Watercress Whole Herb Extract

Interacts with
6 drugs
50 mg per serving

Watercress is a nutrient-rich leafy green that provides vitamins A, C, and K plus minerals and antioxidant plant compounds. Eaten as a food it is gene...

Watercress Whole Herb Extract monograph & interactions

Rosemary Leaf Extract

Interacts with
372 drugs
50 mg per serving Form: Carnosic Acid, Carnosol, Diterpenic Compounds

Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory...

Rosemary Leaf Extract monograph & interactions

Cabbage Leaf Extract

Interacts with
325 drugs
25 mg per serving

Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast engorgement...

Cabbage Leaf Extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Methacrylic Acid Copolymer Dispersion NF, Hypromellose, Propylene Glycol, Croscarmellose Sodium, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Optimized Broccoli and Cruciferous Blend by Life Extension Drug Interactions

Want to check YOUR meds against Optimized Broccoli and Cruciferous Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
500Drugs
500 Moderate

Ingredients driving the most interactions

Rosemary Leaf Extract 372
Cabbage Leaf Extract 325
3,3'-Diindolymethane 269
TrueBroc 187
Watercress Whole Herb Extract 6

Individual Drug Interactions

The ingredients in Optimized Broccoli and Cruciferous Blend interact with 500 drugs. Click any drug to see the details.

5 of the 6 ingredients in Optimized Broccoli and Cruciferous Blend interact with drugs. Each result below shows which ingredient is responsible. Rosemary Leaf Extract Cabbage Leaf Extract 3,3'-Diindolymethane TrueBroc Watercress Whole Herb Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Optimized Broccoli and Cruciferous Blend with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rosemary Leaf Extract6 drug types · 372 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that rosemary inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models. However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults, no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Aspirin

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Rosemary is reported to contain salicylates.

Likelihood Possible Evidence D
Choline Magnesium Trisalicylate (Trilisate)

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Rosemary is reported to contain salicylate.

Likelihood Possible Evidence D
Salsalate (Disalcid)

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Rosemary is reported to contain salicylate.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that rosemary induces CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Unlikely Evidence D
Rosemary Leaf Extract full monograph & interactions

Cabbage Leaf Extract6 drug types · 325 drugs

Acetaminophen (Tylenol, Others)

Cabbage might increase clearance and reduce the effects of acetaminophen.
A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases acetaminophen levels by as much as 16%, with some evidence suggesting that this effect is due to increased elimination through glucuronide conjugation.

Likelihood Probable Evidence B
Antidiabetes Drugs

Theoretically, cabbage might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vivo research suggests that cabbage might have hypoglycemic effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.
Some animal research suggests that cabbage or its constituent indole-3-carbinol might increase drug metabolism and elimination by stimulating CYP1A2 activity.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.
A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases levels of some drugs metabolized through glucuronide conjugation.

Likelihood Probable Evidence B
Oxazepam (Serax)

Cabbage might increase clearance and reduce the effects of oxazepam.
A small clinical study shows that daily consumption of cabbage and brussels sprout decreases oxazepam levels by as much as 17%, with some evidence suggesting that this effect is due to increased elimination through glucuronide conjugation.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, cabbage might decrease the anticoagulant effects of warfarin.
Cabbage contains vitamin K. If consumed in large quantities, cabbage might decrease the anticoagulant effects of warfarin.

Likelihood Possible Evidence D
Cabbage Leaf Extract full monograph & interactions

3,3'-Diindolymethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
3,3'-Diindolymethane full monograph & interactions

TrueBroc2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
TrueBroc full monograph & interactions

Watercress Whole Herb Extract3 drug types · 6 drugs

Chlorzoxazone (Parafon Forte, Paraflex)

Watercress might reduce the metabolism of chlorzoxazone and increase its effects and side effects. Clinical research in healthy volunteers shows that a single ingestion of watercress 50 grams increases the chlorzoxazone plasma concentration-time curve by about 56% and increases its half-life by about 53%.

Likelihood Probable Evidence B
Lithium

Watercress is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, watercress might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Warfarin (Coumadin)

Watercress contains vitamin K. Consuming large amounts of watercress might antagonize the anticoagulant effects of warfarin.

Likelihood Possible Evidence B
Watercress Whole Herb Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Optimized Broccoli and Cruciferous Blend, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Optimized Broccoli and Cruciferous Blend by Life Extension: Common Questions

Does Optimized Broccoli and Cruciferous Blend by Life Extension interact with any medications?
Yes. Based on its ingredients, Optimized Broccoli and Cruciferous Blend has a known interaction with 500 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Optimized Broccoli and Cruciferous Blend contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant?
Broccoli and diindolylmethane are rated likely safe in pregnancy. We don't have safety data on file for watercress, rosemary, or cabbage extracts during pregnancy. Talk with your doctor or pharmacist before starting—they know your medical history and can give you personalized advice.
Will this help prevent cancer?
Broccoli is possibly effective for colorectal cancer specifically. For breast, bladder, and gastric cancers, the evidence we have is insufficient. This product is not a substitute for screening, prevention strategies, or treatment—discuss its role with your doctor.
What side effects should I expect?
The most common are loose stools, diarrhea, abdominal pain, and cramping, especially at higher doses. Diindolylmethane may also cause headache, nausea, gas, rash, or vomiting. Stop and contact your pharmacist or doctor if you develop severe symptoms.
Can I take this if I'm allergic to broccoli or cabbage?
No—if you have a known allergy to broccoli, cauliflower, cabbage, or other Brassicaceae family vegetables, avoid this product. Anaphylactic reactions to these vegetables have been reported, and the concentrated extracts here may pose the same risk.
Will this help with memory or brain fog?
Rosemary leaf extract in this blend is possibly effective for memory support. Evidence for age-related cognitive decline is insufficient. Results vary person to person, and this shouldn't replace medical evaluation if you're concerned about memory loss.
Is this okay if I'm breastfeeding?
We don't have safety data on file for any of these concentrated extracts during breastfeeding. Talk with your doctor or lactation consultant before taking it—they can weigh the risks and benefits for you and your baby.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Optimized Broccoli and Cruciferous Blend is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Optimized Broccoli and Cruciferous Blend label
Go deeper

The Full Monographs Behind Optimized Broccoli and Cruciferous Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Watercress

Interacts with 6 drugs

Watercress is a nutrient-rich leafy green that provides vitamins A, C, and K plus minerals and antioxidant plant compounds. Eaten as a food it is generally safe and healthy for most people,...

Read the full Watercress monograph → Herb & supplement monograph

Rosemary

Interacts with 372 drugs

Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory, mood, and hair growth, but the evidenc...

Read the full Rosemary monograph → Herb & supplement monograph

Cabbage

Interacts with 325 drugs

Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast engorgement or sore joints. Most medicinal claims ar...

Read the full Cabbage monograph →
Sources

Sources & How We Checked

Optimized Broccoli and Cruciferous Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 88 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
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Watercress 34 references
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Rosemary 20 references
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Cabbage 15 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
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