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Dietary supplement

FLORASSIST Mood Ingredients & Drug Interactions

by Life Extension

FLORASSIST Mood label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking FLORASSIST Mood against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

FLORASSIST Mood is a dietary supplement by Life Extension with 2 active ingredients. Its ingredients are commonly taken for mood and stress support, digestive and gut health, sleep support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus helveticus Rosell-52 ME, Bifidobacterium longum Rosell-175 ME. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against FLORASSIST Mood by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with FLORASSIST Mood by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of FLORASSIST Mood by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Mood Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

FLORASSIST Mood contains two active probiotic strains: Lactobacillus helveticus Rosell-52 ME and Bifidobacterium longum Rosell-175 ME. These are live, beneficial bacteria intended to support gut health.

The capsules also contain inactive ingredients—potato starch, vegetable cellulose, maltodextrin, and silica—which serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Probiotic blend for emotional well-being.
  • We looked for evidence on: Depression, Generalized anxiety disorder (GAD), Mood, Stress, Mental health.
  • The closest evidence on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD) (Natural Medicines).
  • Also on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Depression.
  • Also on file: Lactobacillus Helveticus is rated "Insufficient Reliable Evidence To Rate" for Depression.

The evidence supporting these probiotics for mood, cognition, anxiety, and related concerns is currently insufficient to establish whether they work. The ingredients have been studied for depression, cognitive function, generalized anxiety disorder, and other conditions, but we don't hold enough reliable data to rate their effectiveness for any of these uses.

If you're considering this product for a specific health goal, talk with your doctor about whether the current evidence makes sense for your situation.

The evidence, ingredient by ingredient Lactobacillus Helveticus Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Lactobacillus helveticus and Bifidobacterium longum are generally well tolerated in healthy people. However, the data are limited, so if you're seriously ill, immunocompromised, or taking immunosuppressant medications, talk with your doctor before starting.

Rare adverse effects have included abdominal discomfort, flatulence, and constipation with Bifidobacterium longum. Because these are live microorganisms, there is a theoretical concern about infection in vulnerable patients, though such cases are rare.

For Bifidobacterium longum in pregnancy and lactation, the safety rating is "possibly safe"—meaning some data exist but aren't conclusive. For Lactobacillus helveticus, pregnancy and lactation safety data aren't on file.

Either way, if you're pregnant or breastfeeding, check with your doctor or pharmacist before use.

Side effects, ingredient by ingredient Lactobacillus Helveticus Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bifidobacterium Longum, Lactobacillus Helveticus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking FLORASSIST Mood, double-check with your doctor or pharmacist if you're on antibiotic drugs. The live bacteria in this product can be killed by antibiotics if taken at the same time, reducing the probiotic's effectiveness.

Separating the doses by a few hours will solve the problem. No other drug interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

FLORASSIST Mood is a two-strain probiotic supplement intended to support mood and gut health, though the evidence for mood benefits isn't yet established in our data. If you're taking antibiotics, you'll need to space out the doses to avoid reducing the probiotic's viability.

If you're healthy and not on antibiotics or immunosuppressants, it's generally well tolerated, but talk with your doctor or pharmacist before starting—especially if you're pregnant, breastfeeding, or have a weakened immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about FLORASSIST Mood, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870200062
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62998
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for FLORASSIST Mood by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
737870200062
IngredientAmount% DV
Lactobacillus helveticus Rosell-52 ME0 NP--
Mood Probiotic Blend0 NP--
Bifidobacterium longum Rosell-175 ME0 NP--

Other ingredients: Potato Starch, Vegetable Cellulose, Maltodextrin, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

ME refers to a patented microencasulation process that protects the probiotics for enhanced stability.

Probiotic blend for emotional well-being

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Scan for product info

Precautions

Warnings: ~ Keep out of reach of children.

~ Do not exceed recommended dose. ~ Do not purchase if outer seal is broken or damaged.

~ When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Contains milk, soybeans.

FDA Statement of Identity

Dietary Supplement

Formula

Contains milk, soybeans.

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take two (2) capsules daily with or without food, or as recommended by a healthcare practitioner.

General

QE02000A

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

FLORASSIST Mood by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

FLORASSIST Mood label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in FLORASSIST Mood by Life Extension

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Mood Probiotic Blend

0 NP per serving

Other (inactive) ingredients: Potato Starch, Vegetable Cellulose, Maltodextrin, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

FLORASSIST Mood by Life Extension Drug Interactions

Want to check YOUR meds against FLORASSIST Mood?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus helveticus Rosell-52 ME 182
Bifidobacterium longum Rosell-175 ME 182

Individual Drug Interactions

The ingredients in FLORASSIST Mood interact with 182 drugs. Click any drug to see the details.

2 of the 2 ingredients in FLORASSIST Mood interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus helveticus Rosell-52 ME Bifidobacterium longum Rosell-175 ME

Each ingredient & the kinds of drugs it affects

For each ingredient in FLORASSIST Mood with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus helveticus Rosell-52 ME1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L. helveticus.
Lactobacillus helveticus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. helveticus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus helveticus Rosell-52 ME full monograph & interactions

Bifidobacterium longum Rosell-175 ME1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum Rosell-175 ME full monograph & interactions
The maker

Brand information

Manufacturer and brand details for FLORASSIST Mood, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

FLORASSIST Mood by Life Extension: Common Questions

Does FLORASSIST Mood by Life Extension interact with any medications?
Yes. Based on its ingredients, FLORASSIST Mood has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
FLORASSIST Mood contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotic?
Not at the same time. Antibiotics can kill the live bacteria in this supplement before they work. Take your antibiotic as scheduled, then wait a few hours before taking FLORASSIST Mood (or take the probiotic first and space out the antibiotic). Your pharmacist can tell you the best timing for your specific antibiotic.
Does this actually help with mood and anxiety?
The evidence isn't established yet. Both ingredients have been studied for depression, anxiety, and cognitive function, but we don't hold enough reliable data to say whether they work for these purposes. Talk with your doctor if you're considering it for mood or anxiety support.
Is it safe if I'm immunocompromised?
Caution is needed. People who are seriously ill or have weakened immune systems should talk with their doctor before using this product, since the live bacteria could theoretically pose a risk in those situations.
Can I take this while pregnant or breastfeeding?
Bifidobacterium longum is rated possibly safe in pregnancy and lactation, meaning some safety data exist but they're not complete. Lactobacillus helveticus doesn't have enough pregnancy or lactation data on file. Talk with your doctor or pharmacist before use if you're pregnant or breastfeeding.
What are the side effects?
Most people tolerate it well. Rarely, abdominal discomfort, bloating, flatulence, constipation, or a dry cough have been reported with these ingredients. These effects are uncommon and usually mild.
Does this product contain any fillers?
Yes. In addition to the two active probiotic strains, the capsules contain potato starch, vegetable cellulose, maltodextrin, and silica as inactive ingredients to hold the formula together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if FLORASSIST Mood is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

FLORASSIST Mood label
Go deeper

The Full Monographs Behind FLORASSIST Mood’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

FLORASSIST Mood's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Helveticus 2 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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