Glycine 250 mg Ingredients & Drug Interactions
by Kirkman
What is this page for?
First and foremost: checking Glycine 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Glycine 250 mg is a dietary supplement by Kirkman with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Glycine 250 mg by Kirkman
Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine 250 mg by Kirkman — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Glycine 250 mg by Kirkman
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains a single active ingredient: glycine, an amino acid your body produces naturally. Each capsule delivers 250 mg.
The capsule itself is made from cellulose, a plant-based inactive ingredient.
Does it work?
Moderate evidence
Glycine is possibly effective for schizophrenia based on the evidence we hold. For other conditions — including 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, attention deficit-hyperactivity disorder (ADHD), benign prostatic hyperplasia (BPH), and cystic fibrosis — the evidence is insufficient to rate its effectiveness.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Mild sedation, irritability, insomnia, fatigue, memory impairment, headache, and sensory impairment have been reported rarely; soft stools, nausea, vomiting, upper abdominal discomfort, and dry mouth have also occurred in some cases, though a clear link to glycine isn't always certain.
These symptoms tend to resolve quickly if you stop taking it. There isn't enough reliable safety data to know whether glycine is safe during pregnancy or breastfeeding.
Talk with your doctor or pharmacist before using this supplement if you're pregnant, planning to become pregnant, or breastfeeding — they can help you weigh the risks and benefits for your situation.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril), an antipsychotic, notify your doctor or pharmacist before taking this product — glycine may decrease its effectiveness and worsen schizophrenia symptoms. For all other medications, no interactions are documented in our data for glycine, but that does not guarantee none exist; use the interaction checker on this page with your complete medication list to be sure.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Glycine is a naturally occurring amino acid that shows some promise for schizophrenia, though evidence for other uses is incomplete. The most important thing to know is that it may reduce how well clozapine works — if you take that medication, check with your doctor or pharmacist first.
If you're pregnant, breastfeeding, or taking any other prescription drugs, have that same conversation with your healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Glycine 250 mg, straight from the product label.
| Brand | Kirkman |
|---|---|
| Net contents | 200 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2013 |
| DSLD ID | 24591 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Glycine 250 mg by Kirkman, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
SUGGESTED USE: 1-2 capsules daily or as directed by a physician.
Formula
HYPOALLERGENIC
Formulation
FREE OF: Sugar, starch, soy, wheat, casein, gluten, milk, corn, preservatives, yeast, gelatin, flavorings, colorings, fish, peanuts or tree nuts.
CASEIN & GLUTEN FREE
Precautions
KEEP OUT OF THE REACH OF CHILDREN.
General Statements
Best Used by: April 2013
Country of Origin USA
(503)694-1600
FDA Statement of Identity
Dietary Supplement
General
091/200
Storage
IMPORTANT: STORE IN A COOL DRY PLACE AND TIGHTLY CAPPED.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Glycine 250 mg by Kirkman label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Glycine 250 mg by Kirkman
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.
Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsOther (inactive) ingredients: Cellulose, Plant. These complete the product’s ingredient list but are not active constituents.
Glycine 250 mg by Kirkman Drug Interactions
HelloPharmacist Interaction Report
Kirkman's Glycine 250 mg has one documented interaction: glycine may decrease how well clozapine (Clozaril), an antipsychotic medication, works.
One small clinical study in patients with schizophrenia found that adding glycine to clozapine therapy actually worsened schizophrenia symptoms compared with clozapine alone, though the exact reason for this effect isn't fully understood.
Read the full breakdown — every affected drug type, severity by severity
Although this is the only interaction documented in our data, it's a meaningful one — if you take clozapine, talk with your doctor or pharmacist before starting this supplement. They may want to adjust your approach or monitor you more closely.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Glycine 250 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Glycine 250 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Glycine 250 mg interact with drugs. Each result below shows which ingredient is responsible. Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with Glycine 250 mg — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Glycine 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Glycine 250 mg, from the product label.
Kirkman
See all Kirkman products- Name
- Kirkman
- City
- Lake Oswego
- State
- OR
- ZipCode
- 97035
- Phone Number
- (800) 245-8282
- Web Address
- www.kirkmangroup.com
Glycine 250 mg by Kirkman: Common Questions
Does Glycine 250 mg by Kirkman interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is glycine, and what does it do in the body?
Will this help my ADHD?
Can I take this while pregnant or breastfeeding?
What side effects might I notice?
Is this safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Glycine 250 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Glycine 250 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Glycine 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC