Glycine 3000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Glycine 3000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Glycine 3000 mg is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Glycine 3000 mg by Puritan's Pride
Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine 3000 mg by Puritan's Pride — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Glycine 3000 mg by Puritan's Pride
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Glycine 3000 mg by Puritan's Pride contains one active ingredient: L-glycine, an amino acid your body uses as a building block for proteins and other compounds. Each capsule delivers 3000 mg of the ingredient.
The capsules also contain inactive ingredients — cellulose, silica, and magnesium stearate — which are standard binders and flow agents.
Does it work?
Moderate evidence
Glycine is possibly effective for schizophrenia based on the evidence we hold. For other conditions listed — 3-phosphoglycerate dehydrogenase deficiency, ADHD, benign prostatic hyperplasia, and cystic fibrosis — there isn't enough reliable evidence to rate whether it works.
If you're considering glycine for any of these uses, talk it over with your doctor to understand what the current evidence shows and whether it makes sense for your situation.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Rare side effects from oral glycine include mild sedation, soft stools, nausea, vomiting, and upper stomach discomfort — all of which clear up quickly if you stop taking it.
Other symptoms like irritability, insomnia, fatigue, headache, memory problems, dry mouth, and sensory changes have been reported, but it's unclear whether glycine caused them. Pregnancy and breastfeeding safety data for glycine aren't established in our records.
Talk with your doctor or pharmacist before taking this product if you're pregnant, planning to become pregnant, or breastfeeding — they can weigh the individual factors and help you decide.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril) for schizophrenia, check with your doctor or pharmacist before starting glycine — adding it may worsen your symptoms and decrease how well the medication works. No other medication interactions are documented for this product, but always confirm your full medication list with your healthcare provider.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Glycine may be worth considering if you're exploring options for schizophrenia under your doctor's guidance, though the evidence is still limited. The key thing to know is that it can interfere with clozapine, a common schizophrenia medication — so if that's part of your treatment, check with your doctor or pharmacist before starting.
For pregnancy, breastfeeding, or any other health questions specific to you, talk it through with your own healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Glycine 3000 mg, straight from the product label.
| Brand | Puritan's Pride |
|---|---|
| Barcode (UPC) | 025077000876 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 22, 2023 |
| DSLD ID | 286267 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Glycine 3000 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| L-Glycine | 3000 mg | -- |
Other ingredients: Cellulose, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Puritan's Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.
To reorder item # 25876 www.puritan.com 1-800-645-1030
Precautions
Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Do not use if outer seal is broken or missing.
Storage
Store at room temperature.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.
Brand IP Statement(s)
Copyright 2020 Puritan's Pride, Inc.
Seals/Symbols
QA Quality Assured
Made in the USA with select ingredients from around the world
Formulation
May help with morning fatigue and grogginess
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, take three (3) capsules 30-60 minutes before bed.
Formula
Glycine works with your body's natural sleep processes to help reduce next-day fatigue.
Glycine 3000 mg per serving
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Glycine 3000 mg by Puritan's Pride label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Glycine 3000 mg by Puritan's Pride
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
L-Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
L-Glycine monograph & interactionsOther (inactive) ingredients: Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Glycine 3000 mg by Puritan's Pride Drug Interactions
HelloPharmacist Interaction Report
Glycine 3000 mg by Puritan's Pride interacts with one medication: clozapine (Clozaril), an antipsychotic used for schizophrenia.
The interaction is Moderate in severity. Adding glycine to clozapine therapy may worsen schizophrenia symptoms compared with clozapine alone, and it might decrease how well clozapine works — though the exact mechanism isn't clear.
Read the full breakdown — every affected drug type, severity by severity
Although only one drug is documented to interact with this product, if you take clozapine, don't start glycine without checking with your doctor or pharmacist first. The risk of worsening your condition is real enough that you need personalized guidance.
If you take other medications or have questions about whether any of them might interact with glycine, use the medication checker on this page to look them up.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Glycine 3000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Glycine 3000 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Glycine 3000 mg interact with drugs. Each result below shows which ingredient is responsible. L-Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with Glycine 3000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full L-glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Glycine 3000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Glycine 3000 mg, from the product label.
Puritan's Pride
See all Puritan's Pride products- Name
- Puritan's Pride, Inc.
- City
- Ronkonkoma
- State
- NY
- ZipCode
- 11779
- Phone Number
- 1-800-645-1030
- Web Address
- www.puritan.com
Glycine 3000 mg by Puritan's Pride: Common Questions
Does Glycine 3000 mg by Puritan's Pride interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does glycine do in the body?
Is glycine safe to take long-term?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I notice?
Does glycine work for ADHD or other conditions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Glycine 3000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Glycine 3000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Glycine 3000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC