Glycine Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Glycine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Glycine is a dietary supplement by Protocol For Life Balance with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Glycine by Protocol For Life Balance
Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine by Protocol For Life Balance — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Glycine by Protocol For Life Balance
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: glycine, an amino acid. It's a single-ingredient powder with no fillers or other inactive ingredients added.
Does it work?
Not established
The evidence for glycine is mixed depending on what you're using it for. It's possibly effective for schizophrenia, though as noted above, adding it to clozapine therapy can backfire.
For other uses — including 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, ADHD, benign prostatic hyperplasia (BPH), and cystic fibrosis — there isn't enough reliable evidence yet to say whether it works.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Mild sedation, irritability, insomnia, fatigue, memory impairment, headache, and sensory impairment have been reported rarely; GI side effects like soft stools, nausea, vomiting, and upper abdominal discomfort have also been reported rarely.
These symptoms resolve quickly if you stop taking it. There isn't enough reliable safety data on glycine in pregnancy or while breastfeeding — talk with your doctor or pharmacist about whether it's right for you in either situation.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril) for schizophrenia, check with your doctor or pharmacist before starting this product — adding glycine to clozapine therapy has been shown to worsen schizophrenia symptoms in a clinical trial.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Glycine is a straightforward single-ingredient supplement generally well tolerated in typical doses. If you take clozapine for schizophrenia, check with your doctor or pharmacist before adding this product — the evidence suggests it may worsen your symptoms.
Anyone considering glycine for other uses should discuss it with their own healthcare provider first, since long-term safety data are limited.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Glycine, straight from the product label.
| Brand | Protocol For Life Balance |
|---|---|
| Barcode (UPC) | 707359102255 |
| Net contents | 1 lb; 454 g |
| Market status | On market |
| Date entered into DSLD | Oct 25, 2012 |
| DSLD ID | 14922 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Glycine by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
SUGGESTED USAGE: As a dietary supplement, take a 1/4 level teaspoon mixed in water or juice 1 to 3 times daily.
General Statements
Glycine is a non-essential amino acid and has the simplest structure of all amino acids, allowing it to fit easily within protein chains and make space for structurally larger amino acids. This feature makes it very important for specific bodily functions. Glycine is also a precursor of creatine, which is used to construct DNA and RNA. And it supports glycogen storage, thereby making more glucose available for energy production. The amino acid Glycine is non-chiral and only has one form without a D- or L- designation.
100% Pure Powder Pharmaceutical Grade Amino Acid • Supports Energy Production • Important for DNA & RNA
Please Recycle.
This product is sold by weight not volume.
100% Pure.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
General
CODE P0225 V1
FDA Statement of Identity
A Dietary Supplement
Formulation
Vegetarian Product
Contains no sugar, salt, starch, yeast, wheat, gluten, corn, soy, milk, egg, shellfish or preservatives.
Vegetarian/Vegan Product.
Seals/Symbols
GMP
Brand IP Statement(s)
NOW(R) Glycine Powder is Pharmaceutical Grade.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Glycine by Protocol For Life Balance label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Glycine by Protocol For Life Balance
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.25 tsp Dosage formPowder Servings per container454 Amounts shown are per serving.
Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Glycine by Protocol For Life Balance Drug Interactions
HelloPharmacist Interaction Report
Protocol For Life Balance Glycine has one documented interaction to watch for.
Through its glycine content, it may worsen symptoms in people taking clozapine (Clozaril) for schizophrenia — a moderate-severity concern. A small clinical trial in schizophrenia patients showed that adding glycine to clozapine therapy actually worsened their symptoms compared to clozapine alone, though we don't yet understand why this happens.
Read the full breakdown — every affected drug type, severity by severity
If you take clozapine, talk with your doctor or pharmacist before starting this product. Altogether, these interactions span 1 individual medication.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Glycine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Glycine interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Glycine interact with drugs. Each result below shows which ingredient is responsible. Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with Glycine — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Glycine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Glycine, from the product label.
Protocol For Life Balance
See all Protocol For Life Balance products- Name
- NHG
- Street Address
- P.O. Box 2203
- City
- Sparks
- State
- NV
- ZipCode
- 89431
- Web Address
- www.protocolforlife.com
Glycine by Protocol For Life Balance: Common Questions
Does Glycine by Protocol For Life Balance interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is glycine safe to take during pregnancy or while breastfeeding?
What side effects might I get from glycine?
Is this product just glycine, or does it have fillers?
Can glycine help with ADHD or benign prostatic hyperplasia (enlarged prostate)?
How long-term is it safe to take glycine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Glycine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Glycine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Glycine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC