Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Graviola Ingredients & Drug Interactions

by Amazon Therapeutics

Graviola label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Graviola against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Graviola is a dietary supplement by Amazon Therapeutics with 3 active ingredients. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 100% Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Graviola by Amazon Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola by Amazon Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Graviola by Amazon Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

This liquid contains 3 ingredients: distilled water, 35–40% organic alcohol (a preservative and extraction solvent), and graviola extract. Graviola — also called soursop — is a tropical fruit used traditionally for various purposes, though the evidence supporting most of those uses is weak or absent in our data.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: healthy cell function.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The effectiveness evidence for graviola in this product isn't established. Our data shows insufficient reliable evidence to rate it for human papillomavirus (HPV) infection, headache, or as an insect repellent, and the same is true for male infertility.

If you're considering this product for one of those reasons, the science doesn't yet back it up.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Graviola raises some safety red flags. Regular oral use may be unsafe — the most common side effects reported are stomach pain and nausea, though serious side effects like movement disorders and nerve damage (myeloneuropathy) are rare.

Long-term use also raises concerns about possible nerve toxicity in lab studies. The safety data advises against using graviola during pregnancy or while breastfeeding.

If you're pregnant, nursing, or planning either, this product isn't the right choice.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol) for seizures, check with your doctor or pharmacist before using this product — graviola may lower carbamazepine levels and reduce seizure control. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Graviola Liquid is best avoided if you take carbamazepine for seizures — it may reduce how well that medication works. If you're considering it for HPV, headache, or insect repellent uses, the evidence isn't there.

The safety profile is also limited, and regular use carries a real risk of stomach upset and, rarely, nerve problems. Talk to your doctor or pharmacist before starting this product, especially if you take any seizure medications or have concerns about nerve health.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Graviola, straight from the product label.

Brand Amazon Therapeutics
Barcode (UPC) 838451003864
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 248364
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Graviola by Amazon Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
15 Drop(s)
UPC/BARCODE
838451003864
IngredientAmount% DV
distilled Water0 NP--
35-40% organic Alcohol0 NP--
100% Graviola0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Your Selection You hold in your hands the finest traditional botanical available. This botanical is a long-standing favorite of South America where it has been empirically selected for its effectiveness over many generations.

Direct from the source

Traditional Ethnobotanical Information Amazon Therapeutics works for the preservation of rainforests and to uphold the intellectual property rights of native healers and their traditional medicines.

Suggested/Recommended/Usage/Directions

Suggested Directions Use 10-15 drops once or twice a day in water or as recommended by a health care practitioner.

Precautions

Cautions: Information provided on this label should not be used as medical advice. Not intended for long-term use.

Not intended for pregnant or nursing women.

Keep out of the reach of children.

Formula

Annona muricata

Formulation

Healthy cell function

Gluten free

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Wild Crafted Sustainable Harvest

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Graviola by Amazon Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Graviola label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Graviola by Amazon Therapeutics

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Distilled Water

0 NP per serving

35-40% organic Alcohol

0 NP per serving

100% Graviola

Interacts with
1 drug
0 NP per serving

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

100% Graviola monograph & interactions
Interaction report

Graviola by Amazon Therapeutics Drug Interactions

Want to check YOUR meds against Graviola?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

100% Graviola 1

Individual Drug Interactions

The ingredients in Graviola interact with 1 drug. Click any drug to see the details.

1 of the 3 ingredients in Graviola interact with drugs. Each result below shows which ingredient is responsible. 100% Graviola

Each ingredient & the kinds of drugs it affects

For each ingredient in Graviola with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

100% Graviola1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
100% Graviola full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Graviola, from the product label.

Amazon Therapeutics

See all Amazon Therapeutics products
Name
Herbs America
City
Murphy
State
OR
ZipCode
97533
Phone Number
541-846-6222
Web Address
www.herbs-america.com
Pharmacist Counseling Corner

Graviola by Amazon Therapeutics: Common Questions

Does Graviola by Amazon Therapeutics interact with any medications?
Yes. Based on its ingredients, Graviola has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Graviola contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
The safety data advises against graviola during both pregnancy and breastfeeding because there isn't enough reliable information to say it's safe. If you're pregnant, nursing, or planning either, talk with your doctor or pharmacist before using this product.
What are the side effects?
The most common side effects are stomach pain and nausea. Serious side effects like movement disorders and nerve damage are rare but have been reported with regular use. Lab studies also raise concerns about possible nerve toxicity with long-term use.
Does this product actually work for anything?
The evidence isn't clear. Our data shows insufficient reliable evidence to rate graviola for HPV, headache, insect repellent, or male infertility — the uses it's traditionally promoted for.
Why does the label say 35–40% alcohol?
That's the organic alcohol used to extract the graviola and preserve the liquid. It's a standard solvent for herbal liquid extracts.
Is this safe to use long-term?
Regular consumption of graviola may be unsafe. The most common side effects are stomach pain and nausea, and there are concerns about nerve toxicity with long-term use, including rare cases of movement disorders. Talk to your doctor or pharmacist before using it regularly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Graviola is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Graviola label
Go deeper

The Full Monographs Behind Graviola’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Graviola's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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