Graviola Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Graviola against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Graviola is a dietary supplement by L.A. Naturals with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Graviola by L.A. Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola by L.A. Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Graviola by L.A. Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains one active ingredient: graviola (also called soursop), a tropical fruit extract in liquid form. The inactive ingredients are grain alcohol and deionized water.
Does it work?
Couldn't assess
The evidence for graviola isn't established yet in our data. It's been studied for human papillomavirus (HPV), headache, male infertility, and as an insect repellent, but we hold insufficient reliable evidence to rate how well it works for any of these uses.
How safe is it?
Well-documented data
Regular use of graviola may not be safe. The most common side effects are stomach pain and nausea, especially at higher doses.
Rare but serious concerns include movement disorders and a nerve condition called myeloneuropathy — symptoms can resemble Parkinson disease. One study tied even small amounts of graviola (as a tea or juice) to worsening of motor and thinking problems in people with Parkinson disease.
Graviola is not recommended during pregnancy or while breastfeeding — the safety data are too limited. Lab studies also raise questions about possible nerve damage with long-term use, though human data are limited.
Meds to double-check
Moderate interaction found
If you take carbamazepine (Tegretol) for seizures, check with your pharmacist before starting graviola — this product may reduce the medication's effectiveness. No other medication interactions are documented in our data for the ingredients we could check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Graviola has insufficient evidence supporting its effectiveness for any claimed use, and safety data are limited. If you take carbamazepine for seizures, avoid this product or talk to your pharmacist first — it may interfere with your medication.
If you have Parkinson disease or concerns about nerve health, steer clear. Anyone considering graviola should discuss it with their pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Graviola, straight from the product label.
| Brand | L.A. Naturals |
|---|---|
| Barcode (UPC) | 641356166219 |
| Net contents | 1 fl. Oz.; 30 mL |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2014 |
| DSLD ID | 35010 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Kosher |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Graviola by L.A. Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Graviola | 0 NP | -- |
Other ingredients: Grain Alcohol, deionized Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
SINGLE HERB IN ALCOHOL
Suggested/Recommended/Usage/Directions
SUGGESTED USE: 20-40 drops in water or juice, 2-3 times daily, or as needed.
Shake well before using.
Precautions
WARNING: Keep out of the reach of children.
May Contain Tree Nuts.
General Statements
Plant # K-0001604
MADE IN THE USA
FAST ABSORPTION MEDICINAL BOTANICALS
Amount Per Serving 500 mg Herb Weight Equivalence
Herb Strength Ratio 1:2
Seals/Symbols
L.a.(TM)
K PARVE
FDA Statement of Identity
DIETARY SUPPLEMENT
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Graviola by L.A. Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Graviola by L.A. Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.67 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.
Graviola
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Graviola monograph & interactionsOther (inactive) ingredients: Grain Alcohol, Deionized Water. These complete the product’s ingredient list but are not active constituents.
Graviola by L.A. Naturals Drug Interactions
HelloPharmacist Interaction Report
Graviola by L.A.
Naturals can interact with at least one medication. The main concern is carbamazepine (Tegretol), a seizure medication — graviola may reduce how much of this drug your body absorbs and uses.
A rat study showed graviola extract lowered carbamazepine levels by 35 to 46%, which could make the medication less effective at controlling seizures.
Read the full breakdown — every affected drug type, severity by severity
Although we have interaction data for graviola, this is the only medication type documented in our records for this product. That doesn't mean other drugs won't be affected — it means we haven't checked them yet.
If you take any prescription medication, especially seizure drugs, run it through the checker below before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Graviola?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Graviola interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Graviola interact with drugs. Each result below shows which ingredient is responsible. Graviola
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Graviola — through 1 ingredient. Tap an ingredient for the detail:
GraviolaCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Graviola + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Graviola with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Graviola
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Graviola, from the product label.
L.A. Naturals
See all L.A. Naturals products- Name
- Palko Services
- Street Address
- 4991 W. US Hwy 20
- City
- Michigan City
- State
- IN
- ZipCode
- 46360
Graviola by L.A. Naturals: Common Questions
Does Graviola by L.A. Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take graviola if I'm pregnant or breastfeeding?
What are the side effects of graviola?
Does graviola work for HPV, headaches, or anything else?
What's in this liquid besides graviola?
I take seizure medication. Is graviola safe for me?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Graviola is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Graviola’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Graviola's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC