Graviola Leaf Powder Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Graviola Leaf Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Graviola Leaf Powder is a dietary supplement by Z Natural Foods with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Graviola Leaf Powder by Z Natural Foods
Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola Leaf Powder by Z Natural Foods — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Graviola Leaf Powder by Z Natural Foods
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product is a single active ingredient: graviola powder. Graviola is a tropical plant traditionally used for various purposes, though the evidence supporting most of those uses is limited.
There are no other inactive ingredients in this powder.
Does it work?
Couldn't assess
The evidence isn't established for the uses we hold data on. Graviola has been studied or traditionally used for human papillomavirus (HPV), headache, insect repellent properties, and male infertility, but the reliable evidence to support any of these is insufficient.
If you're considering it for a specific health reason, talk with your doctor about whether it's a fit for you and what stronger options might exist.
How safe is it?
Well-documented data
Regular use of graviola may not be safe. The most common side effects reported in a clinical trial were nausea and burning pain in the upper abdomen, and because human safety data are limited, there's concern about possible nerve damage (myeloneuropathy) with long-term use.
Rare but serious effects include movement disorders similar to Parkinson disease, and people with Parkinson disease who consume graviola have reported worsening motor and cognitive symptoms. Graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding due to insufficient safety information.
If you're pregnant or breastfeeding, talk with your doctor or pharmacist before using this product.
Meds to double-check
Moderate interaction found
If you take carbamazepine (Tegretol) for seizures, graviola may reduce its effectiveness. Check with your doctor or pharmacist before adding this product.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Graviola Leaf Powder is one to be cautious with. If you take carbamazepine, do not start without checking with your doctor or pharmacist first.
The safety data are limited, and regular use may carry risks, especially nerve-related effects and worsening symptoms in people with Parkinson disease. If you're pregnant or breastfeeding, the safety data advise against it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Graviola Leaf Powder, straight from the product label.
| Brand | Z Natural Foods |
|---|---|
| Barcode (UPC) | 616983439487 |
| Net contents | 1 Pound(s); 454 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Dec 14, 2023 |
| DSLD ID | 299854 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Graviola Leaf Powder by Z Natural Foods, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 0 Calorie(s) | -- |
| Calories from Fat | 0 Calorie(s) | -- |
| Graviola powder | 2800 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Our raw Graviola Leaf Powder is a true super herb from the amazon rainforest in Peru. Known to nourish the body, it has been used as an herbal tonic for thousands of years by indigenous tribes and people around the world.
EarthKosher
Suggested/Recommended/Usage/Directions
Suggested Use: Steep 1 teaspoon in 6 ounces of boiling water for 10 minutes. Take up to 3 times daily.
Formulation
Grown and dried in Peru Packaged with care in Florida, USA
Non GMO Gluten free Chemical free
Vegan
Raw
Seals/Symbols
EarthKosher
Precautions
California Prop 65 Warning: Cancer and Reproductive Harm - www.P65Warnings.ca.gov/food
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Graviola Leaf Powder by Z Natural Foods label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Graviola Leaf Powder by Z Natural Foods
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2.8 Gram(s) Dosage formPowder Servings per container161 Amounts shown are per serving.
Graviola powder
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Graviola powder monograph & interactionsGraviola Leaf Powder by Z Natural Foods Drug Interactions
HelloPharmacist Interaction Report
Graviola Leaf Powder by Z Natural Foods interacts with one medication: carbamazepine (Tegretol), a seizure drug.
The concern is Moderate in severity—graviola may lower carbamazepine levels in your blood, which could reduce how well the drug controls seizures. A rat study found that graviola extract cut carbamazepine concentrations by roughly a third to a half.
Read the full breakdown — every affected drug type, severity by severity
If you take carbamazepine, do not start this product without talking to your doctor or pharmacist first. They'll need to know before you make any changes.
Use the medication checker below to search your exact drugs. We could not verify interactions against all possible medications, so it's worth confirming your full list.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Graviola Leaf Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Graviola Leaf Powder interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Graviola Leaf Powder interact with drugs. Each result below shows which ingredient is responsible. Graviola powder
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Graviola Leaf Powder — through 1 ingredient. Tap an ingredient for the detail:
Graviola PowderCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Graviola Powder + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Graviola Leaf Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Graviola powder
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Graviola Leaf Powder, from the product label.
Z Natural Foods
See all Z Natural Foods products- Name
- Z Natural Foods
- Street Address
- 5407 N Haverhill Rd Ste 336
- City
- West Palm Beach
- State
- FL
- ZipCode
- 33407
- Web Address
- www.ZNaturalFoods.com
Graviola Leaf Powder by Z Natural Foods: Common Questions
Does Graviola Leaf Powder by Z Natural Foods interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the most common side effects?
Can graviola help with HPV, headaches, or male infertility?
Is it safe to take this long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Graviola Leaf Powder is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Graviola Leaf Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Graviola Leaf Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC