Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Organic Graviola Ingredients & Drug Interactions

by Amazon Therapeutics

Organic Graviola label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Graviola against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Graviola is a dietary supplement by Amazon Therapeutics with 3 active ingredients. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 100% Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Graviola by Amazon Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Graviola by Amazon Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Graviola by Amazon Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

This liquid contains 3 ingredients: distilled water, organic alcohol (35–40%), and 100% graviola extract. Graviola is a tropical fruit traditionally used in herbal medicine, though its exact role in supporting health isn't well established in current research.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: healthy cell function.
  • We looked for evidence on: cellular health, cell protection, antioxidant support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have reliable evidence that graviola works for any of its common uses—HPV, headache, male infertility, or insect repellent. That doesn't mean it doesn't work; it means we simply don't have solid human studies backing these claims yet.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Regular use of graviola may not be safe. The most common side effects are stomach pain (epigastric pain) and nausea.

More rarely, long-term use has been linked to serious nerve problems (myeloneuropathy) and movement disorders that can resemble Parkinson disease symptoms. Graviola is also possibly unsafe in pregnancy and should be avoided while breastfeeding.

The safety data are limited, and lab studies raise concerns about potential nerve toxicity with long-term use.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol) or other seizure medications, check with your pharmacist before using this product. Graviola may reduce how well carbamazepine works in your body.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Graviola has very limited evidence of benefit and some real safety concerns, especially with long-term use. If you take carbamazepine for seizures, this product could interfere with that medication.

Talk to your pharmacist before starting—especially if you're pregnant, breastfeeding, or taking any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Graviola, straight from the product label.

Brand Amazon Therapeutics
Barcode (UPC) 838451003826
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217788
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Graviola by Amazon Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
20 Drop(s)
Maximum serving Sizes:
30 Drop(s)
UPC/BARCODE
838451003826
IngredientAmount% DV
distilled Water0 NP--
35-40% organic Alcohol0 NP--
100% Graviola0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Your Selection You hold in your hands the finest traditional botanical available. This botanical is a long-standing favorite of South America where it has been empirically selected for its effectiveness over many generations.

Direct from the source

Traditional Ethnobotanical Information Amazon Therapeutics works for the preservation of rainforests and to uphold the intellectual property rights of native healers and their traditional medicines.

Suggested/Recommended/Usage/Directions

Suggested Directions Use 20-30 drops once or twice a day in water or as recommended by a health care practitioner.

Precautions

Cautions: Information provided on this label should not be used as medical advice. Not intended for long-term use.

Not intended for pregnant or nursing women.

Keep out of the reach of children.

Formula

Annona muricata

EarthKosher

Formulation

Healthy cell function

Gluten free

Certified Organic by Oregon Tilth www.tilth.org

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

USDA Organic

EarthKosher

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Graviola by Amazon Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Graviola label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Graviola by Amazon Therapeutics

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size20 Drop(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Distilled Water

0 NP per serving

35-40% organic Alcohol

0 NP per serving

100% Graviola

Interacts with
1 drug
0 NP per serving

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

100% Graviola monograph & interactions
Interaction report

Organic Graviola by Amazon Therapeutics Drug Interactions

Want to check YOUR meds against Organic Graviola?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

100% Graviola 1

Individual Drug Interactions

The ingredients in Organic Graviola interact with 1 drug. Click any drug to see the details.

1 of the 3 ingredients in Organic Graviola interact with drugs. Each result below shows which ingredient is responsible. 100% Graviola

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Graviola with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

100% Graviola1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
100% Graviola full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Graviola, from the product label.

Amazon Therapeutics

See all Amazon Therapeutics products
Name
Herbs America
Street Address
PO Box 446
City
Murphy
State
OR
ZipCode
97533
Phone Number
541-846-6222
Web Address
www.amazonmedicine.com
Pharmacist Counseling Corner

Organic Graviola by Amazon Therapeutics: Common Questions

Does Organic Graviola by Amazon Therapeutics interact with any medications?
Yes. Based on its ingredients, Organic Graviola has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Graviola contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Organic Graviola while pregnant or breastfeeding?
No. The safety data advise against it in both pregnancy and breastfeeding. There isn't enough information to know it's safe, so talk with your doctor or pharmacist for personalized advice if you're considering it during these times.
What are the most common side effects?
Stomach pain and nausea are the most common. More serious but rare effects include nerve damage and movement problems that can look like Parkinson disease, especially with long-term use.
Does graviola actually work for any health condition?
We don't have reliable evidence that it works for HPV, headache, male infertility, or as an insect repellent. The research just isn't there yet.
I take carbamazepine for seizures—is this product safe for me?
No, not without checking with your pharmacist first. Graviola may lower carbamazepine levels in your blood, which could make your seizure medication less effective. Check this product with your exact medication before starting.
What exactly is in this bottle?
Distilled water, organic alcohol (35–40%), and 100% graviola extract. There are no inactive fillers or binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Graviola is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Graviola label
Go deeper

The Full Monographs Behind Organic Graviola’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Organic Graviola's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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