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Dietary supplement

Gugulipid 1000 mg Extended Release Ingredients & Drug Interactions

by Natures Plus Herbal Actives

Gugulipid 1000 mg Extended Release label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gugulipid 1000 mg Extended Release against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gugulipid 1000 mg Extended Release is a dietary supplement by Natures Plus Herbal Actives with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, joint pain and arthritis, weight management.Based on those ingredients, 757 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gugulipid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gugulipid 1000 mg Extended Release by Natures Plus Herbal Actives

Ask about any prescription or over-the-counter medication and we check it for interactions with Gugulipid 1000 mg Extended Release by Natures Plus Herbal Actives — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gugulipid 1000 mg Extended Release by Natures Plus Herbal Actives

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: gugulipid, a resin extract from the guggul tree traditionally used in herbal medicine. The tablet also includes inactive ingredients — microcrystalline cellulose, stearic acid, hydroxypropyl methylcellulose, magnesium stearate, silica, and pharmaceutical glaze — which are the binders, fillers, and coating materials that hold the tablet together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Guggul product and its label doesn't state a use — see Guggul's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for gugulipid's effectiveness is limited. For weight loss (obesity), the data suggests it's possibly ineffective.

For acne, hemorrhoids, and high cholesterol, the evidence we hold isn't strong enough to rate it one way or the other — there simply isn't reliable data yet on whether it works for these conditions.

The evidence, ingredient by ingredient Guggul

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gugulipid is generally well tolerated, but side effects do happen. Common ones are belching, bloating, diarrhea, headache, nausea, unpleasant taste, and vomiting.

Skin reactions — both allergic and non-allergic rashes — are fairly common and appear to depend on dose; higher doses carry higher risk. Rarely, a serious muscle condition called rhabdomyolysis has been reported.

If you're pregnant, the safety data advises against it because gugulipid may stimulate the uterus. There isn't enough safety information to recommend it while breastfeeding, so you'd want to talk with your doctor or pharmacist about that.

Side effects, ingredient by ingredient Guggul

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Guggul.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 758 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Gugulipid 1000 mg Extended Release, double-check the following medication types with your doctor or pharmacist: blood pressure or heart medications (especially propranolol and diltiazem), blood thinners or antiplatelet drugs (aspirin, warfarin, clopidogrel), hormonal contraceptives and estrogens, tamoxifen, thyroid hormone replacements, and any drugs broken down by the CYP3A4 liver enzyme (a very common pathway that affects hundreds of medications).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gugulipid may be worth considering if you're exploring traditional herbal options for cholesterol or skin health, but the evidence for how well it works is thin. If you take heart or blood pressure medication, blood thinners, hormonal contraceptives, estrogen therapy, tamoxifen, or thyroid hormone, talk with your doctor or pharmacist before starting — the interactions documented here are real concerns.

Pregnant or breastfeeding? This one isn't recommended, so check with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gugulipid 1000 mg Extended Release, straight from the product label.

Brand Natures Plus Herbal Actives
Barcode (UPC) 097467073289
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228346
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gugulipid 1000 mg Extended Release by Natures Plus Herbal Actives, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
097467073289
IngredientAmount% DV
Gugulipid1000 mg--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silica, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Nutritional support for general well-being. Each Herbal Actives extended-release formula provides rapid and sustained results.

This is not a prescription product. It is a dietary supplement made with the highest possible quality standards.

Prescription quality

Gluten Free

Vegetarian

Free from artificial colors and preservatives. Free from all of the major allergens identified in the U.S. Food Allergen Labeling and Consumer Protection Act.

Formula

Supplying the greatest concentration of active botanical principles, Herbal Actives Gugulipid maximizes the synergistic benefits of this Ayurvedic gum, a key component of Ayurveda, the ancient Indian system of health and well-being.

Gugulipid 1000 mg/2.5% Guggulsterones

General Statements

Guaranteed Maximum Potency: Each Herbal Actives formula is scientifically standardized to the highest level of active principles. HerbaShield: An exclusive purity and safety system providing light-resistant bottle, airtight inner seal, moisture-absorbing packet, tamper-evident safety cap and tamper-proof full bottle seal.

HerbaShield: An exclusive purity and safety system providing light-resistant bottle, airtight inner seal, moisture-absorbing packet, tamper-evident safety cap and tamper-proof full bottle seal.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement offering the consistent benefits of exact potency, one tablet daily or as recommended by your health care professional.

Precautions

Note: If you are pregnant or nursing, consult your health care professional before using any herbal product.

Printed HerbaShield inner seal and full bottle seal. Do not use if either seal is missing or broken.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Herbal Actives is a registered trademark of Natural Organics, Inc. in the US and other countries.

Gugulipid is a registered trademark of Sabinsa Corp.

Natural Organics

Seals/Symbols

HerbaShield

Guaranteed Maximum Potency

FDA Statement of Identity

Standardized Botanical Supplement

Storage

Keep tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gugulipid 1000 mg Extended Release by Natures Plus Herbal Actives label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gugulipid 1000 mg Extended Release label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gugulipid 1000 mg Extended Release by Natures Plus Herbal Actives

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Gugulipid

Interacts with
757 drugs
1000 mg per serving Form: Guggulsterones

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...

Gugulipid monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silica, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gugulipid 1000 mg Extended Release by Natures Plus Herbal Actives Drug Interactions

Want to check YOUR meds against Gugulipid 1000 mg Extended Release?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
757Drugs
757 Moderate

Ingredients driving the most interactions

Gugulipid 757

Individual Drug Interactions

The ingredients in Gugulipid 1000 mg Extended Release interact with 757 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gugulipid 1000 mg Extended Release interact with drugs. Each result below shows which ingredient is responsible. Gugulipid

Each ingredient & the kinds of drugs it affects

For each ingredient in Gugulipid 1000 mg Extended Release with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gugulipid9 drug types · 757 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.

Likelihood Probable Evidence D
Diltiazem (Cardizem, Others)

Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.

Likelihood Probable Evidence B
Estrogens

Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Propranolol (Inderal)

Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.

Likelihood Probable Evidence B
Rosuvastatin (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.

Likelihood Probable Evidence B
Gugulipid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gugulipid 1000 mg Extended Release, from the product label.

Natures Plus Herbal Actives

See all Natures Plus Herbal Actives products
Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Gugulipid 1000 mg Extended Release by Natures Plus Herbal Actives: Common Questions

Does Gugulipid 1000 mg Extended Release by Natures Plus Herbal Actives interact with any medications?
Yes. Based on its ingredients, Gugulipid 1000 mg Extended Release has a known interaction with 757 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gugulipid 1000 mg Extended Release contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take gugulipid if I'm pregnant or nursing?
No — the safety data advises against gugulipid during pregnancy because it may stimulate the uterus. There isn't enough information to know if it's safe while breastfeeding. Talk with your doctor or pharmacist before taking it if either applies to you.
What side effects should I watch for?
The most common ones are bloating, diarrhea, nausea, and bad taste in your mouth. Skin rashes (allergic or otherwise) are fairly common and tend to be worse at higher doses. Rarely, a serious muscle condition can occur. Stop and contact your healthcare provider if you develop a rash, severe muscle pain, or any side effect that concerns you.
Does gugulipid actually help with weight or cholesterol?
For weight loss, the evidence suggests it's probably not effective. For high cholesterol, acne, and hemorrhoids, we don't have strong enough data to say whether it works. If one of those is on your mind, talk it over with your doctor about what the evidence really shows.
Can I take this with my blood pressure or heart medication?
There's a documented risk here. Gugulipid may reduce how well propranolol and diltiazem work by lowering how much your body absorbs. Check with your doctor or pharmacist before adding it — they may need to adjust your medication or monitor you more closely.
Will gugulipid affect my birth control?
Theoretically, yes. Gugulipid appears to act like estrogen in your body, which could reduce how well hormonal contraceptives work or increase your risk of side effects. Talk with your doctor or pharmacist before combining them.
What's in this tablet besides gugulipid?
The other ingredients are microcrystalline cellulose, stearic acid, hydroxypropyl methylcellulose, magnesium stearate, silica, and pharmaceutical glaze — all inactive binders, fillers, and coating materials that help hold the tablet together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gugulipid 1000 mg Extended Release is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gugulipid 1000 mg Extended Release label
Go deeper

The Full Monographs Behind Gugulipid 1000 mg Extended Release’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Guggul

Interacts with 757 drugs

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...

Read the full Guggul monograph →
Sources

Sources & How We Checked

Gugulipid 1000 mg Extended Release's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guggul 21 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Dalvi SS, Nayak VK, Pohujani SM, et al. Effect of gugulipid on bioavailability of diltiazem and propranolol. J Assoc Phys India 1994;42:454-5.
  3. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994;8:659-64. PubMed
  4. Tripathi YB, Tripathi P, Malhotra OP, Tripathi SN. Thyroid stimulatory action of (Z)-guggulsterone: mechanism of action. Planta Med 1988;54:271-7.
  5. Agarwal RC, Singh SP, Saran RK, et al. Clinical trial of gugulipid – a new hypolipidemic agent of plant origin in primary hyperlipidemia. Ind J Med Res 1986;84:626-34.
  6. Malhotra SC, Ahuja MM, Sundaram KR. Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and clofibrate. Indian J Med Res 1977;65:390-5.
  7. Mester L, Mester M, Nityanand S. Inhibition of platelet aggregation by "guggulu" steroids. Planta Med 1979;37:367-9. PubMed
  8. Szapary PO, Wolfe ML, Bloedon LT, et al. Guggulipid for treatment of hypercholesterolemia: a randomized controlled trial. JAMA 2003;290:765-72.
  9. Brobst DE, Ding X, Creech KL, et al. Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J Pharmacol Exp Ther 2004;310:528-35. PubMed
  10. Bianchi A, Cantu P, Firenzuoli F, et al. Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent. Ann Pharmacother 2004;38:1222-5.
  11. Gelfand JM, Crawford GH, Brod BA, Szazpary PO. Adverse cutaneous reactions to guggulipid. J Am Acad Dermatol 2005;52:533-4 PubMed
  12. Nohr, L. A., Rasmussen, L. B., and Straand, J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther.Med. 2009;17(1):16-22. PubMed
  13. Gelfand, J. M., Crawford, G. H., Brod, B. A., and Szazpary, P. O. Adverse cutaneous reactions to guggulipid. J.Am.Acad.Dermatol. 2005;52(3 Pt 1):533-534. PubMed
  14. Kolonte, A., Guillot, B., and Raison-Peyron, N. Allergic contact dermatitis to guggul extract contained in an anticellulite gel-cream. Contact Dermatitis 2006;54(4):226-227. PubMed
  15. Salavert, M., Amarger, S., Le Bouedec, M. C., Roger, H., Souteyrand, P., and D'incan, M. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis 2007;56(5):286-287. PubMed
  16. Malhotra SC, Ahuja MM. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su. Indian J Med Res 1971;59:1621-1632.
  17. Gaur SP, Garg RK, Kar AM, et al. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997;12:65-69.
  18. Baldwa VS, Sharma RC, Ranka PC, et al. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980;19:84-86.
  19. Donato F, Raffetti E, Toninelli G, Festa A, Scarcella C, Castellano M; TRIGU Project Working Group. Guggulu and Triphala for the Treatment of Hypercholesterolaemia: A Placebo-Controlled, Double-Blind, Randomised Trial. Complement Med Res 2021;28(3):216-22 PubMed
  20. Mehdi Z, Fatemeh P, Roja R, et al. Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial. J Tradit Chin Med 2021;41(2):301-307.
  21. Asad M, Asdaq SMB, Mohzari Y, et al. Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats. Saudi J Biol Sci 2021;28(6):3490-3496. PubMed

See these in context on the Guggul monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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