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Dietary supplement

GymnePure 8X 250 mg Ingredients & Drug Interactions

by OptiChoice

GymnePure 8X 250 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GymnePure 8X 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GymnePure 8X 250 mg is a dietary supplement by OptiChoice with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, type 2 diabetes, sugar cravings.Based on those ingredients, 851 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are GymnePURE 8X organic Gymnema sylvestre extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against GymnePure 8X 250 mg by OptiChoice

Ask about any prescription or over-the-counter medication and we check it for interactions with GymnePure 8X 250 mg by OptiChoice — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GymnePure 8X 250 mg by OptiChoice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

GymnePure 8X contains one active ingredient: gymnema sylvestre extract at 250 mg per capsule. Gymnema is a plant extract used in traditional medicine for blood sugar support.

The capsule itself is made from vegetable material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gymnema's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: nutritional support for healthy glucose levels and insulin activity.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Metabolic syndrome, Blood sugar regulation, Insulin sensitivity.
  • The closest evidence on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Impaired glucose tolerance (prediabetes), Metabolic syndrome.

The data we hold shows insufficient reliable evidence to rate gymnema sylvestre for diabetes, obesity, prediabetes (impaired glucose tolerance), or metabolic syndrome. While some human and animal research suggests gymnema may lower blood sugar, we don't have enough solid evidence to say whether it works reliably for these uses.

The evidence, ingredient by ingredient Gymnema

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gymnema is generally well tolerated short-term, though quality varies between products. The safety data advises against use during pregnancy and breastfeeding — there isn't enough information to know it's safe in either situation.

Rarely, cases of liver inflammation (hepatitis) have been reported with gymnema use; one involved a patient who drank gymnema tea three times daily for 10 days and developed weakness, fatigue, jaundice, and elevated liver enzymes. That patient recovered after treatment and monitoring over 6 months.

Because gymnema can lower blood sugar, be cautious if you're prone to low blood sugar.

Side effects, ingredient by ingredient Gymnema

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gymnema.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 852 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GymnePure 8X, double-check with your doctor or pharmacist if you take antidiabetes drugs (moderate risk of low blood sugar), CYP1A2 substrates like certain pain relievers or psychiatric medications (moderate risk of increased levels), CYP2C9 substrates such as blood thinners like warfarin or some blood pressure medications (moderate risk of unpredictable level changes), or CYP3A4 substrates like statins and certain blood pressure drugs (minor risk of increased levels).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

GymnePure 8X might interest someone looking for plant-based blood sugar support, but the evidence for its effectiveness isn't established in the data we hold. If you take diabetes medications, blood thinners, or liver-metabolized drugs, you should talk with your doctor or pharmacist before starting — the interactions are documented and could affect how your medications work or your blood sugar control.

Avoid it if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GymnePure 8X 250 mg, straight from the product label.

Brand OptiChoice
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 217011
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GymnePure 8X 250 mg by OptiChoice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
GymnePURE 8X organic Gymnema sylvestre extract250 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

OSA Technology Optimal absorption and bioavailability Over 90% of subjects taking GymnePure 8x experienced superior results in stabilizing & balancing blood sugar, cholesterol and triglyceride levels. Invented by Dr. Arun Chatterji, innovative OSA technology is a patented and scientifically supported extraction process that improves the absorption and bioavailability of Gymnema sylvestre bio-actives.

Patented OSA Technology nutritional support for healthy glucose levels and insulin activity

No preservatives / No excipients / Gluten free

General Statements

Greater bioavailability = Improved effectiveness One 250 mg capsule versus Eight standard Gymnema sylvetsre extract capsules!

Brand IP Statement(s)

US Patents #6,949,261, #6,946,151

GymnePure 8X is exclusively licensed to SourceOne Global Partners. Vcaps is a registered trademark of Capsugel. For more information, please visit www.source-1-global.com.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 or more capsules daily with a meal or as directed by your healthcare professional or pharmacist.

Storage

Storage: Keep tightly closed in a cool, dry place in the original container. Do not expose to excessive heat.

Precautions

Keep out of the reach of children.

Caution: Do not use if seal is broken.

As with any dietary supplements, please consult a medical professional before using if you are pregnant, lactating, or have any existing medical condition.

Seals/Symbols

Vcaps

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GymnePure 8X 250 mg by OptiChoice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GymnePure 8X 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GymnePure 8X 250 mg by OptiChoice

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

GymnePURE 8X organic Gymnema sylvestre extract

Interacts with
851 drugs
250 mg per serving Form: Virgin Isolate OSA

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human stu...

GymnePURE 8X organic Gymnema sylvestre extract monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

GymnePure 8X 250 mg by OptiChoice Drug Interactions

Want to check YOUR meds against GymnePure 8X 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
851Drugs
347 Moderate 504 Minor

Ingredients driving the most interactions

GymnePURE 8X organic Gymnema sylvestre extract 851

Individual Drug Interactions

The ingredients in GymnePure 8X 250 mg interact with 851 drugs. Click any drug to see the details.

1 of the 1 ingredient in GymnePure 8X 250 mg interact with drugs. Each result below shows which ingredient is responsible. GymnePURE 8X organic Gymnema sylvestre extract

Each ingredient & the kinds of drugs it affects

For each ingredient in GymnePure 8X 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

GymnePURE 8X organic Gymnema sylvestre extract6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
GymnePURE 8X organic Gymnema sylvestre extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GymnePure 8X 250 mg, from the product label.

OptiChoice

See all OptiChoice products
Name
OptiChoice The Natural Choice for Optimal Health
Street Address
445 E. Illinois ST.
City
Chicago
State
IL
ZipCode
60611
Phone Number
1-800-755-4996
Pharmacist Counseling Corner

GymnePure 8X 250 mg by OptiChoice: Common Questions

Does GymnePure 8X 250 mg by OptiChoice interact with any medications?
Yes. Based on its ingredients, GymnePure 8X 250 mg has a known interaction with 851 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GymnePure 8X 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take GymnePure 8X if I'm pregnant or breastfeeding?
No — there isn't enough safety data on gymnema during pregnancy or lactation, so it's best avoided in both cases. Talk with your doctor or pharmacist about what's safe for you.
Does gymnema actually lower blood sugar?
Some human and animal research suggests it may, and it can enhance the effects of diabetes medications. But we don't have enough reliable evidence to say it works consistently for diabetes, prediabetes, or metabolic syndrome.
What are the side effects of gymnema?
Gymnema is generally well tolerated short-term. Rarely, cases of liver inflammation with weakness, fatigue, and jaundice have been reported. Since it lowers blood sugar, be cautious if you're at risk for low blood sugar episodes.
Why does quality vary between gymnema products?
The facts we hold note that quality varies, but they don't explain the reasons. This is something your pharmacist can discuss with you when choosing a brand.
If I take a blood thinner, is GymnePure 8X safe?
No — gymnema can affect how your liver processes CYP2C9 substrates, a group that includes blood thinners like warfarin. The effect is unpredictable, so you need to check with your doctor or pharmacist before using it alongside any blood thinner.
Can gymnema interact with my diabetes medication?
Yes — gymnema can enhance the blood sugar lowering effect of diabetes drugs and increase the risk of low blood sugar (hypoglycemia). If you take antidiabetes medications, talk with your doctor or pharmacist before adding this supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GymnePure 8X 250 mg label
Go deeper

The Full Monographs Behind GymnePure 8X 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph →
Sources

Sources & How We Checked

GymnePure 8X 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gymnema 12 references
  1. Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
  2. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
  3. Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
  4. Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
  5. Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
  6. Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
  7. Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
  8. Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
  9. Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
  10. Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
  11. Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
  12. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

See these in context on the Gymnema monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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