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Dietary supplement

High Potency B-Complex plus B-12 Ingredients & Drug Interactions

by Nature's Truth

High Potency B-Complex plus B-12 label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Potency B-Complex plus B-12 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Potency B-Complex plus B-12 is a dietary supplement by Nature's Truth with 5 active ingredients. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 735 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Niacin, Riboflavin, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Potency B-Complex plus B-12 by Nature's Truth

Ask about any prescription or over-the-counter medication and we check it for interactions with High Potency B-Complex plus B-12 by Nature's Truth — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Potency B-Complex plus B-12 by Nature's Truth

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 5 active ingredients: thiamin, riboflavin, niacin, vitamin B12, and papain. Thiamin, riboflavin, and niacin are B vitamins that help your body convert food into energy and support nerve and skin health.

Vitamin B12 is essential for red blood cells and nerve function. Papain is an enzyme from papaya that's included for digestive support.

The tablet also contains inactive ingredients—calcium carbonate, cellulose, stearic acid, croscarmellose, magnesium stearate, and silica—which are excipients that help form and stabilize the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Wernicke-Korsakoff syndrome (WKS) — rated "Effective" (Thiamine) (Natural Medicines).
  • On file: Thiamine deficiency — rated "Effective" (Thiamine) (Natural Medicines).
  • On file: Vitamin B12 deficiency — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Imerslund-Grasbeck disease — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Pellagra — rated "Likely Effective" (Niacin) (Natural Medicines).

Thiamin is effective for treating thiamin deficiency and Wernicke-Korsakoff syndrome (a serious neurological condition from severe thiamin lack); it's possibly effective for menstrual pain but possibly ineffective as a mosquito repellent and for heart failure. Niacin is likely effective for pellagra (a niacin deficiency disease) and possibly effective for certain cholesterol problems linked to HIV/AIDS and metabolic syndrome.

Vitamin B12 is effective for treating B12 deficiency and a rare absorption disorder, and likely effective for cyanide poisoning; it's possibly effective for canker sores and nerve pain after shingles. Riboflavin and papain have no established effectiveness ratings in our data.

The evidence, ingredient by ingredient Thiamine Riboflavin Niacin Vitamin B12 Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thiamin, riboflavin, and vitamin B12 are generally very well tolerated at normal supplement amounts and considered likely safe in pregnancy and while breastfeeding at recommended doses—but check with your provider before using high-dose forms. Niacin is generally safe at food amounts and normal supplement doses but can cause flushing, digestive upset, and (rarely) liver problems at higher doses; high-dose niacin should be avoided in pregnancy unless prescribed.

Riboflavin may cause dose-related nausea and bright yellow urine at high doses, and one trial participant reported diarrhea. Papain is generally well tolerated as a food but may irritate the digestive tract and trigger allergic reactions; concentrated papain and unripe papaya products should be avoided in pregnancy due to safety concerns, and there isn't enough reliable safety data to recommend supplemental papain while breastfeeding.

Vitamin B12 is well tolerated orally, though rare allergic reactions have been reported.

Side effects, ingredient by ingredient Thiamine Riboflavin Niacin Vitamin B12 Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Papain, Niacin, Vitamin B12, Riboflavin, Thiamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 736 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take warfarin or other blood thinners, any blood pressure medication, diabetes drugs (especially metformin), gout medications like allopurinol or probenecid, statins, hepatotoxic drugs, tetracycline antibiotics, bile acid sequestrants like cholestyramine, or trimethoprim. These interactions range from moderate to minor in severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This B-complex is a reasonable choice if you're deficient in thiamin, niacin, or B12, or if you need support for the conditions these vitamins address. If you take blood thinners like warfarin, diabetes medications, gout drugs, statins, blood pressure drugs, tetracycline antibiotics, or bile acid sequestrants, talk with your doctor or pharmacist before starting—several interactions are documented.

Pregnancy and breastfeeding: discuss papain and niacin in particular with your provider, since concentrated papain is best avoided in pregnancy and high-dose niacin should not be used.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Potency B-Complex plus B-12, straight from the product label.

Brand Nature's Truth
Barcode (UPC) 840093102058
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 306717
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Potency B-Complex plus B-12 by Nature's Truth, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
45
UPC/BARCODE
840093102058
IngredientAmount% DV
Thiamin14 mg1167%
Riboflavin10 mg769%
Niacin8 mg50%
Vitamin B1250 mcg2083%
Papain20 mg--

Other ingredients: Calcium Carbonate, Cellulose, Stearic Acid, Croscarmellose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

100% Quality Satisfaction Guarantee Vitamins

Formulation

Non GMO

No wheat, milk, lactose, soy, artificial color, artificial flavor, artificial sweetener, preservatives. Non-GMO

Vegetarian Formula

Our Non-GMO Pledge Visit our website

FDA Statement of Identity

Vitamin Supplement

Formula

Essential B-Vitamin Complex

Storage

Directions: For adults, take two (2) tablets one to two times daily, preferably with meals.

Store in a cool, dry place.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Avoid this product if you are allergic to yeast.

If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.

Keep out of reach of children.

Brand IP Statement(s)

Copyright 2020 Nature's Truth LLC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Potency B-Complex plus B-12 by Nature's Truth label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Potency B-Complex plus B-12 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Potency B-Complex plus B-12 by Nature's Truth

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Thiamin

Interacts with
3 drugs
14 mg per serving Form: Brewer's Yeast, Thiamin Hydrochloride

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamin monograph & interactions

Riboflavin

Interacts with
20 drugs
10 mg per serving Form: Brewer's Yeast, Riboflavin

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Niacin

Interacts with
727 drugs
8 mg per serving Form: Brewer's Yeast, Niacinamide

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Vitamin B12

Interacts with
20 drugs
50 mcg per serving Form: Brewer's Yeast, Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Papain

Interacts with
2 drugs
20 mg per serving Form: Papaya Enzyme

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Other (inactive) ingredients: Calcium Carbonate, Cellulose, Stearic Acid, Croscarmellose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Potency B-Complex plus B-12 by Nature's Truth Drug Interactions

Want to check YOUR meds against High Potency B-Complex plus B-12?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
735Drugs
733 Moderate 2 Minor

Ingredients driving the most interactions

Niacin 727
Riboflavin 20
Vitamin B12 20
Thiamin 3
Papain 2

Individual Drug Interactions

The ingredients in High Potency B-Complex plus B-12 interact with 735 drugs. Click any drug to see the details.

5 of the 5 ingredients in High Potency B-Complex plus B-12 interact with drugs. Each result below shows which ingredient is responsible. Niacin Riboflavin Vitamin B12 Thiamin Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in High Potency B-Complex plus B-12 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Niacin full monograph & interactions

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions

Thiamin1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamin full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Potency B-Complex plus B-12, from the product label.

Nature's Truth

See all Nature's Truth products
Name
Nature's Truth LLC
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-844-544-1030
Web Address
naturestruthproducts.com
Pharmacist Counseling Corner

High Potency B-Complex plus B-12 by Nature's Truth: Common Questions

Does High Potency B-Complex plus B-12 by Nature's Truth interact with any medications?
Yes. Based on its ingredients, High Potency B-Complex plus B-12 has a known interaction with 735 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Potency B-Complex plus B-12 contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product make my urine turn bright yellow?
Yes, possibly. High doses of riboflavin (one of the B vitamins in this complex) can cause bright yellow urine. This is harmless and typically reversible, but it's a sign you're taking more than your body needs—excess riboflavin is removed through your urine.
Can I take this if I'm pregnant?
Most of the B vitamins in this product are considered likely safe at recommended amounts during pregnancy, and thiamin, riboflavin, and niacin are actually needed then. However, papain is possibly unsafe in pregnancy, especially concentrated forms. Talk with your provider before starting to make sure the dose and ingredient mix are right for you.
What is papain and why is it in this B-complex?
Papain is an enzyme extracted from papaya fruit. It's included in this product for digestive support. However, papain is not a B vitamin and has no established effectiveness in our data for the conditions it's traditionally used for.
Can I take this with my diabetes medication?
Check with your doctor first. Niacin in this product can raise blood sugar and reduce how well diabetes drugs work, and vitamin B12 levels may drop if you're on metformin. Your provider may need to adjust your dose or monitor your blood sugar more closely.
Will this product cause flushing?
Niacin can cause flushing (redness and warmth of the face and skin), especially at higher doses—up to 70% of people taking niacin report this. It's uncomfortable but usually harmless and often goes away within a couple of weeks if you keep taking it.
Is this safe to take long-term?
B vitamins like thiamin, riboflavin, and B12 are very safe long-term because excess is removed in your urine. Niacin and papain at high doses long-term carry more caution—niacin can affect your liver, and high-dose papain may irritate your digestive tract. Stick to recommended doses and let your provider know if you plan to take it for a long time.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if High Potency B-Complex plus B-12 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Potency B-Complex plus B-12 label
Go deeper

The Full Monographs Behind High Potency B-Complex plus B-12’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph → Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

High Potency B-Complex plus B-12's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 119 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Niacin 66 references
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Vitamin B12 30 references
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Papain 11 references
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