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Dietary supplement

High Potency Bromelain 3000 GDU 500 mg Ingredients & Drug Interactions

by Doctor's Best

High Potency Bromelain 3000 GDU 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Potency Bromelain 3000 GDU 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Potency Bromelain 3000 GDU 500 mg is a dietary supplement by Doctor's Best with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Potency Bromelain 3000 GDU 500 mg by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with High Potency Bromelain 3000 GDU 500 mg by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Potency Bromelain 3000 GDU 500 mg by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bromelain, a protein enzyme derived from pineapple stems, at 500 mg per capsule with a potency of 3000 GDU (gelatin digesting units). The capsule also holds two inactive ingredients — hypromellose and microcrystalline cellulose — which are standard binders and bulking agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bromelain's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: healthy digestion and joint comfort.
  • We looked for evidence on: Allergic rhinitis (hay fever), Exercise-induced muscle soreness, Knee pain, Osteoarthritis, Postoperative pain, Postoperative swelling — and 4 related terms.
  • The closest evidence on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Osteoarthritis, Knee pain, Rhinosinusitis, and more.

The evidence we hold doesn't establish that bromelain is effective for any of the conditions listed on this product. Our data shows insufficient reliable evidence for hay fever, burns, cancer, chemotherapy-related nerve damage, chronic venous insufficiency, and diabetes.

That doesn't mean it doesn't work — it means rigorous proof isn't yet in hand. If you're considering bromelain for a specific condition, talk with your doctor or pharmacist about what the current research actually supports.

The evidence, ingredient by ingredient Bromelain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated when taken by mouth short-term, though long-term safety data is sparse. The most common side effects are diarrhea, flatulence, stomach upset, and headache.

Some people may experience stomach distress, nausea, vomiting, or belly pain. Allergic reactions are possible — particularly if you're sensitive to pineapple — and inhaling bromelain powder on the job has triggered asthma and throat symptoms in occupational settings.

The safety data advises against bromelain during pregnancy. Safety while breastfeeding is unknown, so it's best to avoid it then too.

If you're pregnant or breastfeeding and want to consider bromelain, talk with your doctor or pharmacist first.

Side effects, ingredient by ingredient Bromelain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this bromelain, double-check with your doctor or pharmacist if you're on any blood thinners or antiplatelet drugs (such as warfarin, aspirin, or clopidogrel) — the moderate-risk increase in bleeding is real. Also flag any tetracycline antibiotics like doxycycline you may be taking, though that risk is smaller.

Use the search tool on this page to confirm your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This single-ingredient bromelain supplement is most suitable for people who want to try it for general wellness and have no bleeding disorders or regular use of blood thinners or tetracycline antibiotics. If you take any anticoagulant, antiplatelet, or tetracycline medication, check with your doctor or pharmacist before starting — the bleeding risk with blood thinners is the main concern.

Pregnant or breastfeeding? Skip it and discuss alternatives with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Potency Bromelain 3000 GDU 500 mg, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950002159
Net contents 90 Veggie Cap(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 302676
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Potency Bromelain 3000 GDU 500 mg by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s), 1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s), 1 Veggie Capsule(s)
Servings per container
90
UPC/BARCODE
753950002159
IngredientAmount% DV
Bromelain500 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bromelain is an enzyme derived from pineapple stem and fruit that has proteolytic (protein-digesting) properties. The bromelain found in Doctor's Best 3000 GDU Bromelain is one of the most potent forms of this enzyme found on the market. The 3000 GDU refers to the standardization of enzymatic potency and reflects the quality of the raw material used in the product. Bromelain is renowned for its digestion-enhancing characteristics and also has beneficial systemic effects within the body. Bromelain may also help support cardiovascular and joint health.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Doctor's Best Science-Based Nutrition

Formulation

Helps support healthy digestion and joint comfort

Vegan

Non-GMO/Gluten Free

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 capsule with each meal for digestive support, or 1 capsule twice daily for joint support, or as recommended by a nutritionally informed physician.

Precautions

Warning: Consult with a physician before using bromelain, if you are on blood-thinners, other medications, or have medical disorders.

Stop using bromelain at least two weeks before surgery.

Not recommended for children or for women who are pregnant or breastfeeding.

Not recommended for children or for women who are pregnant or breastfeeding.

Storage

Store in a cool dry place.

Seals/Symbols

Vegan

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Potency Bromelain 3000 GDU 500 mg by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Potency Bromelain 3000 GDU 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Potency Bromelain 3000 GDU 500 mg by Doctor's Best

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Bromelain

Interacts with
141 drugs
500 mg per serving Form: Pineapple Stem Extract

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Potency Bromelain 3000 GDU 500 mg by Doctor's Best Drug Interactions

Want to check YOUR meds against High Potency Bromelain 3000 GDU 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141

Individual Drug Interactions

The ingredients in High Potency Bromelain 3000 GDU 500 mg interact with 141 drugs. Click any drug to see the details.

1 of the 1 ingredient in High Potency Bromelain 3000 GDU 500 mg interact with drugs. Each result below shows which ingredient is responsible. Bromelain

Each ingredient & the kinds of drugs it affects

For each ingredient in High Potency Bromelain 3000 GDU 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Potency Bromelain 3000 GDU 500 mg, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
City
Tustin
State
California
ZipCode
92780
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

High Potency Bromelain 3000 GDU 500 mg by Doctor's Best: Common Questions

Does High Potency Bromelain 3000 GDU 500 mg by Doctor's Best interact with any medications?
Yes. Based on its ingredients, High Potency Bromelain 3000 GDU 500 mg has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Potency Bromelain 3000 GDU 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is bromelain and where does it come from?
Bromelain is a protein enzyme extracted from pineapple stems. It's been studied for various health purposes, though the evidence for most of them isn't yet solid in our data.
What are the most common side effects?
When taken by mouth, the most frequent side effects are diarrhea, gas, stomach upset, and headache. Some people also report nausea, vomiting, or abdominal pain. Allergic reactions can occur, especially if you're sensitive to pineapple.
Can I take bromelain if I'm pregnant or breastfeeding?
The safety data advises against bromelain during pregnancy. Safety while breastfeeding is unknown, so it's best to avoid it then too. Talk with your doctor or pharmacist for personalized guidance.
Is bromelain proven to work for any condition?
Our data shows insufficient reliable evidence for bromelain to rate it as effective for hay fever, burns, cancer, nerve damage, chronic venous insufficiency, or diabetes. If you're interested in it for a specific reason, ask your doctor what the current research actually supports.
Is this safe to take long-term?
Bromelain is generally well tolerated in the short term, but evidence on long-term safety is limited. If you're thinking about using it regularly over months or longer, discuss that plan with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if High Potency Bromelain 3000 GDU 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Potency Bromelain 3000 GDU 500 mg label
Go deeper

The Full Monographs Behind High Potency Bromelain 3000 GDU 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph →
Sources

Sources & How We Checked

High Potency Bromelain 3000 GDU 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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