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Dietary supplement

Hyaluronic Acid Ingredients & Drug Interactions

by Nature's Lab

Hyaluronic Acid label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hyaluronic Acid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hyaluronic Acid is a dietary supplement by Nature's Lab with 2 active ingredients. Its ingredients are commonly taken for skin health and wrinkles, joint pain and osteoarthritis, bone health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hyaluronic Acid by Nature's Lab

Ask about any prescription or over-the-counter medication and we check it for interactions with Hyaluronic Acid by Nature's Lab — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hyaluronic Acid by Nature's Lab

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “BioCell Collagen” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

This supplement has 4 active ingredients. Chondroitin sulfate and hyaluronic acid are both compounds your body uses naturally—chondroitin is found in cartilage, and hyaluronic acid acts as a lubricant and cushion in joints and skin.

Hydrolyzed collagen type II is a broken-down form of collagen, a structural protein in connective tissue and skin. MSM (methylsulfonylmethane) is an organic sulfur compound.

The capsule also contains a few inactive ingredients: hypromellose (a capsule binder), rice flour, and magnesium stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Joint comfort, skin hydration and collagen support.
  • We looked for evidence on: Joint pain, Osteoarthritis, Dry eye, Dry skin, Wound healing, Aging skin — and 3 related terms.
  • The strongest evidence on file: Chondroitin Sulfate is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Hyaluronic Acid is rated "Possibly Effective" for Dry eye.
  • Also on file: Collagen Peptides is rated "Possibly Effective" for Aging skin, Dry skin.

Chondroitin is possibly effective for cataracts and osteoarthritis, though evidence is mixed. Hyaluronic acid is possibly effective for dry eye and venous leg ulcers (slower-healing wounds in the legs).

Hydrolyzed collagen type II is possibly effective for aging skin and dry skin, though it appears possibly ineffective for muscle strength. For other uses listed—like aging skin, allergic rhinitis, or sexual dysfunction—the evidence is insufficient to rate, meaning we don't have enough reliable data to say whether it works.

We hold no effectiveness data on MSM.

The evidence, ingredient by ingredient Collagen Peptides Chondroitin Sulfate Hyaluronic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chondroitin sulfate is generally well tolerated for short-term use, though quality varies. The most common oral side effects are mild—abdominal pain, bloating, constipation, diarrhea, heartburn, and nausea—but there have been rare reports of liver damage (hepatotoxicity).

Skin reactions like swelling, hair loss, and rash have also been reported, particularly when chondroitin is combined with glucosamine; a rare case of photosensitization (abnormal sun sensitivity) and asthma worsening have been documented. Hyaluronic acid and collagen are generally well tolerated orally.

Regarding pregnancy and breastfeeding: chondroitin safety data is insufficient—the facts advise against it in pregnancy and while breastfeeding. Hyaluronic acid safety data is insufficient; the facts advise oral supplements only if your doctor recommends it.

Hydrolyzed collagen isn't well studied in pregnancy; talk with your doctor before using. Little safety data exists for breastfeeding; caution is advised.

We hold no pregnancy or breastfeeding data on MSM.

Side effects, ingredient by ingredient Collagen Peptides Chondroitin Sulfate Hyaluronic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Chondroitin Sulfate.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any other blood thinner (anticoagulant), check your medications with the tool on this page before taking this product—chondroitin sulfate may increase the blood-thinning effect and raise your INR. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is most relevant if you're interested in joint or skin health, though the evidence for some uses is mixed. If you take warfarin or any blood thinner, check with your doctor or pharmacist first—chondroitin may interact.

Pregnancy or breastfeeding? Discuss this with your own doctor or pharmacist before starting, especially chondroitin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hyaluronic Acid, straight from the product label.

Brand Nature's Lab
Barcode (UPC) 818014015053
Net contents 180 Easy-to-swallow-Vegetarian Capsules(s)
Market status On market
Date entered into DSLD Jul 24, 2019
DSLD ID 205350
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hyaluronic Acid by Nature's Lab, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
60
UPC/BARCODE
818014015053
IngredientAmount% DV
Chondroitin Sulfate200 mg--
Hyaluronic Acid100 mg--
Hydrolyzed Collagen Type II600 mg--
MSM900 mg--
BioCell Collagen1000 mg--

Other ingredients: Hypromellose, Rice Flour, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Hyaluronic Acid functions as a "space filler", providing moisture-filled cushioning between cells, which is vital in the production and maintenance of collagen and cartilage. MSM (methylsulfonylmethane) is an organic source of sulfur, a mineral necessary for the production of collagen, the main structural component of cartilage and connective tissue. BioCell Collagen is multi-patented, scientifically-substantiated ingredient that promotes active joints, youthful looking skin, and healthy connective tissues.

BioCell Collagen with OptiMSM 1000 mg BioCell Collagen per serving 900 mg MSM per serving

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Warnings: Pregnant or lactating women and people with known medical conditions and/or taking drugs should consult with a qualified healthcare practitioner prior to taking dietary supplements.

Do not use if seal is broken.

Keep out of reach of children.

Formulation

Vegetarian capsules

Free of: Sugar, salt, dairy, eggs, peanuts, tree nuts, shellfish, yeast, wheat, gluten, soy, corn, preservatives, titanium dioxide, artificial colors and flavors. Non GMO and gluten free

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 3 capsules one time daily, preferably with a meal, or as directed by a qualified healthcare practitioner.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

BioCell Collagen is a registered trademark of BioCell Technology LLC, Newport Beach, California USA (Protected by US and International Patents) OptiMSM is a registered trademark of Bergstrom Nutrition.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hyaluronic Acid by Nature's Lab label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hyaluronic Acid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hyaluronic Acid by Nature's Lab

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

MSM

900 mg per serving

BioCell Collagen

No known
interactions
1000 mg per serving Form: proprietary Chicken Cartilage extract

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...

BioCell Collagen monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hyaluronic Acid by Nature's Lab Drug Interactions

Want to check YOUR meds against Hyaluronic Acid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Hyaluronic Acid interact with 2 drugs. Click any drug to see the details.

0 of the 2 ingredients in Hyaluronic Acid interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Hyaluronic Acid with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Hyaluronic Acid, from the product label.

Nature's Lab

See all Nature's Lab products
Name
Nature's Lab
Street Address
6980 W. Warm Springs Road, Suite 100
City
Las Vegas
State
NV
ZipCode
89113
Phone Number
1-888-793-0351
Web Address
Natureslab.com
Pharmacist Counseling Corner

Hyaluronic Acid by Nature's Lab: Common Questions

Does Hyaluronic Acid by Nature's Lab interact with any medications?
Yes. Based on its ingredients, Hyaluronic Acid has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hyaluronic Acid contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my arthritis?
Chondroitin in this product is possibly effective for osteoarthritis—that means there's some evidence it may help, though it's not definitive. Results vary person to person. Talk with your doctor about whether it's a fit for your situation.
What are the most common side effects?
Chondroitin can cause mild stomach issues—bloating, diarrhea, heartburn, nausea, or constipation—though these are generally uncommon. Skin reactions like swelling, rash, or hair loss have been reported, especially when combined with glucosamine. Most people tolerate it without trouble, but if you notice symptoms, stop and check with your pharmacist.
Is it safe to take if I'm pregnant?
The safety data on chondroitin (the main active ingredient here) is not sufficient to recommend it in pregnancy—the facts advise against it. Hyaluronic acid and collagen also have limited pregnancy data. Talk with your doctor before taking this product if you're pregnant or planning to be.
Can I use this while breastfeeding?
Safety data during breastfeeding is insufficient for chondroitin, hyaluronic acid, and collagen. Your doctor or pharmacist can give you personalized advice based on your situation.
Does hyaluronic acid in this product work for dry skin?
Hyaluronic acid is possibly effective for aging skin and dry skin. It's a natural lubricant in your body, but evidence from supplements is mixed, so results vary.
What is MSM for?
MSM (methylsulfonylmethane) is an organic sulfur compound sometimes marketed for joint and skin health, but we hold no interaction or effectiveness data for it in our system.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hyaluronic Acid is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hyaluronic Acid label
Go deeper

The Full Monographs Behind Hyaluronic Acid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph → Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph →
Sources

Sources & How We Checked

Hyaluronic Acid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chondroitin Sulfate 22 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
  16. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
  17. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
  18. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Collagen Peptides 2 references
  1. Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-8. PubMed
  2. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed

See these in context on the Collagen Peptides monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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