No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Hyaluronic Acid Ingredients & Drug Interactions

by Pure

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Hyaluronic Acid is a dietary supplement by Pure with 1 active ingredient. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Hyaluronic Acid by Pure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: hyaluronic acid, a substance your body naturally produces and uses to keep tissues hydrated and cushioned. It's also common in skin-care and eye-drop products.

The capsule itself is made from gelatin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: hydrates skin and helps reduce joint pain.
  • We looked for evidence on: Aging skin, Dry eye, Osteoarthritis, Wound healing, skin elasticity, joint mobility.
  • The strongest evidence on file: Hyaluronic Acid is rated "Possibly Effective" for Dry eye (Natural Medicines).
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Osteoarthritis, Wound healing.

The evidence is mixed. Hyaluronic acid is rated possibly effective for dry eye and venous leg ulcers (slow-healing wounds in the lower legs caused by circulation problems).

For aging skin, hay fever, and sexual dysfunction, we don't have enough reliable evidence to say whether it works — the research is too thin or inconsistent to rate it either way.

The evidence, ingredient by ingredient Hyaluronic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth or applied to the skin, hyaluronic acid is generally well tolerated in most adults. The safety notes on file advise caution because long-term safety of oral supplements hasn't been fully studied, and recommend talking with your doctor before taking it by mouth unless they've cleared it.

Topical use has occasionally caused eczema, redness, itching, wound bleeding, or infection; eye drops containing it have rarely caused eye pain.

Side effects, ingredient by ingredient Hyaluronic Acid

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for hyaluronic acid in our data.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Hyaluronic Acid by Pure might be worth considering if you're dealing with dry eyes or hard-to-heal leg wounds, though the evidence is modest. Because the long-term safety of oral supplements isn't fully known, it's smart to check with your own doctor or pharmacist before you start — they can tell you whether it makes sense for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hyaluronic Acid, straight from the product label.

Brand Pure
Net contents 365 Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 248681
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hyaluronic Acid by Pure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
365
IngredientAmount% DV
Hyaluronic Acid325 mg--

Other ingredients: Gelatin Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Pure ingredients. Pure results. Unmatched purity.

Non-GMO ingredients

Skin & joint support

Lubricates joints Rejuvenates tissue Hydrates skin

General Statements

Triple the value.

Money back guarantee

Formula

Pure Hyaluronic Acid hydrates skin & helps reduce joint pain

Precautions

If you are pregnant, nursing, or taking medication, consult your physician before taking this or any dietary supplement.

For adults only.

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily or as directed by a physician. Take with at least 8 oz of liquid.

Seals/Symbols

Made in USA

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease or health condition.

See for yourself

Hyaluronic Acid by Pure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Hyaluronic Acid by Pure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container365 Amounts shown are per serving.

Hyaluronic Acid

No known
interactions
325 mg per serving Form: Sodium Hyaluronate

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Other (inactive) ingredients: Gelatin Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hyaluronic Acid by Pure Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Hyaluronic Acid. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Hyaluronic Acid, from the product label.

Pure

See all Pure products
Name
Pure Supplements
Street Address
2578 W 600 N
City
Lindon
State
UT
ZipCode
84042
Phone Number
801-903-2280
Web Address
Puresupplementsco.com
Pharmacist Counseling Corner

Hyaluronic Acid by Pure: Common Questions

Does Hyaluronic Acid by Pure interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Hyaluronic Acid. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Hyaluronic Acid contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does hyaluronic acid actually work for dry eyes?
It's rated possibly effective for dry eye, which means there's some evidence it may help, but it's not definitive. Talk with your eye doctor about whether it's a good fit for your symptoms and whether it might work alongside other treatments you're already using.
Is this supplement safe to take long-term?
Hyaluronic acid appears well tolerated when taken by mouth, but the long-term safety of oral supplements hasn't been fully studied. Check with your doctor before starting it, especially if you're thinking of taking it regularly.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data on file for hyaluronic acid in pregnancy or lactation. Talk with your doctor or pharmacist before taking it — they can give you personalized advice based on your situation.
What does hyaluronic acid do in the body?
Hyaluronic acid is something your body makes naturally to keep tissues hydrated and cushioned. When taken as a supplement, the idea is that it may help tissues stay lubricated and healthy, though evidence is strongest for dry eye and slower-healing wounds.
What's in the capsule besides hyaluronic acid?
The capsule itself is made from gelatin — that's the only other ingredient. There are no added fillers or binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hyaluronic Acid is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hyaluronic Acid label
Go deeper

The Full Monographs Behind Hyaluronic Acid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Hyaluronic Acid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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