Hyaluronic Acid with BioCell Collagen & MSM Ingredients & Drug Interactions
by Nature's Lab
What is this page for?
First and foremost: checking Hyaluronic Acid with BioCell Collagen & MSM against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Hyaluronic Acid with BioCell Collagen & MSM is a dietary supplement by Nature's Lab with 2 active ingredients. Its ingredients are commonly taken for skin health and wrinkles, joint pain and osteoarthritis, bone health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Hyaluronic Acid with BioCell Collagen & MSM by Nature's Lab
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Hyaluronic Acid with BioCell Collagen & MSM by Nature's Lab
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This 4-ingredient product combines chondroitin sulfate, hyaluronic acid, hydrolyzed collagen type II, and methylsulfonyl methane (MSM). Chondroitin and collagen are structural proteins meant to support joints and connective tissue; hyaluronic acid is a compound that holds water and is used for skin and eye moisture; MSM is a sulfur-containing compound sometimes marketed for joint and skin health.
The capsule also contains inactive ingredients: hypromellose, rice flour, and magnesium stearate.
Does it work?
Moderate evidence
The evidence for this product's ingredients is mixed. Chondroitin sulfate is possibly effective for osteoarthritis and cataracts, but the data on aging skin and bone health is insufficient.
Hyaluronic acid is possibly effective for dry eyes and venous leg ulcers, but again, evidence for aging skin is insufficient. Hydrolyzed collagen type II is possibly effective for aging skin and dry skin, but rated possibly ineffective for muscle strength.
We hold no effectiveness data for MSM in our records.
How safe is it?
Well-documented data
Chondroitin sulfate is generally well tolerated for short-term use, though quality varies and benefits are uncertain. The most common side effects are gastrointestinal — abdominal pain, bloating, constipation, diarrhea, heartburn, and nausea — and skin reactions including eyelid or limb swelling, hair loss, and rash have been reported.
Rare cases of liver damage and asthma worsening have occurred, usually with chondroitin-glucosamine combinations. Hyaluronic acid and collagen peptides are generally well tolerated; collagen may occasionally cause nausea, upset stomach, diarrhea, or gas, but these are uncommon.
Meds to double-check
Moderate interaction found
If you take warfarin (Coumadin) or any blood thinner, check with your doctor or pharmacist before starting — chondroitin may increase how thin your blood gets. We could not check methylsulfonyl methane (MSM) for interactions, so mention this product by name to your pharmacist if you take other medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may appeal to you if you're interested in joint, skin, or eye support, but the evidence is unproven for many uses. If you take warfarin or any blood thinner, do not start this product without checking with your doctor or pharmacist first — chondroitin can increase your blood-thinner's effect.
Talk it over with your own healthcare provider before adding it to your routine, especially if you're pregnant, breastfeeding, or take any medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Hyaluronic Acid with BioCell Collagen & MSM, straight from the product label.
| Brand | Nature's Lab |
|---|---|
| Barcode (UPC) | 818014013790 |
| Net contents | 60 Easy-to-swallow-Vegetarian Capsules(s) |
| Market status | On market |
| Date entered into DSLD | Sep 24, 2019 |
| DSLD ID | 205220 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Hyaluronic Acid with BioCell Collagen & MSM by Nature's Lab, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Chondroitin Sulfate | 200 mg | -- |
| Hyaluronic Acid | 100 mg | -- |
| Hydrolyzed Collagen Type II | 600 mg | -- |
| Methylsulfonyl Methane | 900 mg | -- |
| BioCell Collagen | 900 mg | -- |
Other ingredients: Hypromellose, Rice Flour, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Hyaluronic Acid functions as a "space filler," providing moisture-filled cushioning between cells, which is vital in the production and maintenance of collagen and cartilage. MSM (Methylsulfonylmethane) is an organic source of sulfur, a mineral necessary for the production of collagen, the main structural component of cartilage and connective tissue. BioCell Collagen is multi-patented, scientifically substantiated ingredient that promotes active joints, youthful looking skin, and healthy connective tissues.
900 mg BioCell Collagen per serving 900 mg MSM per serving
Product contains ingredients derived from animals (cartilage).
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Warnings: Pregnant or lactating women and people with known medical conditions and/or taking drugs should consult with a qualified healthcare practitioner prior to taking dietary supplements.
Product contains ingredients derived from animals (cartilage).
Do not use if seal is broken.
Keep out of reach of children.
Manufactured in a facility that also processes soy, milk, fish and shellfish.
Formulation
Vegetarian capsules
Free of: Sugar, salt, dairy, eggs, peanuts, tree nuts, fish, shellfish, yeast, wheat, soy, gluten, titanium dioxide, artificial colors and flavors.
Non-GMO, gluten free
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 3 capsules one time daily, preferably with a meal, or as directed by a qualified healthcare practitioner.
Storage
Store in a cool, dry place.
Brand IP Statement(s)
BioCell Collagen is a registered trademark of BioCell Technology LLC, Newport Beach, California USA (Protected by US and International Patents)
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Hyaluronic Acid with BioCell Collagen & MSM by Nature's Lab label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Hyaluronic Acid with BioCell Collagen & MSM by Nature's Lab
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Methylsulfonyl Methane
BioCell Collagen
No knowninteractions
Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...
BioCell Collagen monograph & interactionsOther (inactive) ingredients: Hypromellose, Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Hyaluronic Acid with BioCell Collagen & MSM by Nature's Lab Drug Interactions
HelloPharmacist Interaction Report
Hyaluronic Acid with BioCell Collagen & MSM by Nature's Lab has documented interactions through its chondroitin sulfate content.
The most serious concern is with warfarin (Coumadin), a blood thinner (anticoagulant): chondroitin combined with glucosamine may increase warfarin's blood-thinning effects, raising your clotting time (INR). The effect of chondroitin alone is less clear, but multiple reports exist of raised INR when patients took warfarin with these supplements together.
Read the full breakdown — every affected drug type, severity by severity
Although this product contains chondroitin without added glucosamine, the interaction with warfarin remains a documented risk. Altogether, these interactions span 2 individual medications.
Hyaluronic acid, hydrolyzed collagen type II, and the collagen blend (BioCell Collagen) show no interactions in our data. We could not check methylsulfonyl methane (MSM) — we hold no data for it.
If you take warfarin or any other blood thinners, use the medication checker on this page to confirm your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Hyaluronic Acid with BioCell Collagen & MSM?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Hyaluronic Acid with BioCell Collagen & MSM interact with 2 drugs. Click any drug to see the details.
0 of the 2 ingredients in Hyaluronic Acid with BioCell Collagen & MSM interact with drugs. Each result below shows which ingredient is responsible.
WarfarinWarfarin
How Warfarin interacts with Hyaluronic Acid with BioCell Collagen & MSM — through 1 ingredient. Tap an ingredient for the detail:
Chondroitin SulfateWarfarin (coumadin) Moderate
Interaction Summary
Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin.
Read the full Chondroitin Sulfate + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Hyaluronic Acid with BioCell Collagen & MSM — through 1 ingredient. Tap an ingredient for the detail:
Chondroitin SulfateWarfarin (coumadin) Moderate
Interaction Summary
Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin.
Read the full Chondroitin Sulfate + Warfarin Sodium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Hyaluronic Acid with BioCell Collagen & MSM with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Brand information
Manufacturer and brand details for Hyaluronic Acid with BioCell Collagen & MSM, from the product label.
Nature's Lab
See all Nature's Lab products- Name
- Nature's Lab
- Street Address
- 6980 W. Warm Springs Road, Suite 100
- City
- Las Vegas
- State
- NV
- ZipCode
- 89113
- Phone Number
- 1-888-793-0351
- Web Address
- Natureslab.com
Hyaluronic Acid with BioCell Collagen & MSM by Nature's Lab: Common Questions
Does Hyaluronic Acid with BioCell Collagen & MSM by Nature's Lab interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while on warfarin?
Will this help my aging skin?
Is this safe to take while pregnant?
Can I take this while breastfeeding?
What are the most common side effects?
Does this product contain any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Hyaluronic Acid with BioCell Collagen & MSM is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Hyaluronic Acid with BioCell Collagen & MSM’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Collagen Peptides
Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...
Read the full Collagen Peptides monograph → Herb & supplement monographChondroitin Sulfate
Interacts with 2 drugsChondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...
Read the full Chondroitin Sulfate monograph → Herb & supplement monographHyaluronic Acid
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...
Read the full Hyaluronic Acid monograph →Sources & How We Checked
Hyaluronic Acid with BioCell Collagen & MSM's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 28 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Chondroitin Sulfate 22 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
- Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
- Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
- Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
- Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
- Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
- Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
- Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
- Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
- Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
- Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
- Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
- Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
- Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
- Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
- von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
- Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
- Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
- Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
- Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
- Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed
Hyaluronic Acid 4 references
- Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
- U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
- Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
- Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed
Collagen Peptides 2 references
- Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-8. PubMed
- Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC