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Dietary supplement

Nattokinase 2,000 FU Ingredients & Drug Interactions

by Nature's Lab

Nattokinase 2,000 FU label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nattokinase 2,000 FU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nattokinase 2,000 FU is a dietary supplement by Nature's Lab with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nattokinase 2,000 FU by Nature's Lab

Ask about any prescription or over-the-counter medication and we check it for interactions with Nattokinase 2,000 FU by Nature's Lab — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nattokinase 2,000 FU by Nature's Lab

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: nattokinase, a protein-digesting enzyme derived from fermented soybeans (natto). Nattokinase is included to support cardiovascular function.

The capsule also holds inactive ingredients — rice flour, hypromellose (the capsule material), and magnesium stearate — which are standard fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Support heart health.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence we hold doesn't establish nattokinase's effectiveness for the conditions listed — angina, atherosclerosis, cancer, cardiovascular disease, and chronic fatigue syndrome all fall into insufficient evidence. That doesn't mean it doesn't work; it means the data we have isn't robust enough to rate it either way.

If you're considering it for a specific condition, talk with your pharmacist or doctor about what the broader research suggests for your situation.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated short-term, but because it has blood-thinning properties, it's not suitable for people at risk of bleeding. Rare cases of bleeding have been reported, including a serious one in someone who combined it with aspirin.

Do not use nattokinase during pregnancy — the safety data isn't there. Avoid it while breastfeeding as well.

If you have a known allergy or sensitivity to natto (fermented soybeans), you could have a reaction, including severe allergic response in rare cases.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your exact medications with the tool on this page if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, etc.) or blood pressure medications — both carry moderate interaction risks with nattokinase.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nattokinase may be worth considering if your doctor thinks cardiovascular support is useful for you — but only if you're not on blood thinners or blood pressure medications. If you take either of those drug classes, check with your pharmacist first.

Avoid it in pregnancy and while nursing. Talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nattokinase 2,000 FU, straight from the product label.

Brand Nature's Lab
Barcode (UPC) 818014018214
Net contents 90 Easy-To-Swallow Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 334723
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nattokinase 2,000 FU by Nature's Lab, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
90
UPC/BARCODE
818014018214
IngredientAmount% DV
Nattokinase100 mg--

Other ingredients: Rice Flour, Hypromellose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Support your heart health with Nature's Lab Nattokinase 2,000 FU. This formula harnesses the benefits of the traditional food, natto. Nattokinase is a unique enzyme created when soybeans are fermented to make natto. This plant-based enzyme derived from natto extract promotes healthy circulation throughout the body which supports the energy needs of the heart. Nattokinase 2,000 FU contains 100 mg (2,000 fibrin units) of nattokinase per capsule.

Precautions

Warnings: For adults only.

Do not use if pregnant or nursing. People with known medical conditions and/or taking drugs should consult with a qualified healthcare practitioner prior to taking dietary supplements. Do not use if you are taking "blood thinning" medications (anticoagulants) or if you have any ongoing bleeding/coagulation problems.

Discontinue use and consult your doctor if any adverse reactions occur.

Allergens: Contains Soy.

Do not use if seal is broken.

Keep out of reach of children.

Manufactured in a facility that also processes soy, egg, milk, fish, shellfish, tree nuts and sesame.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Formulation

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

With love from Nevada

Supports healthy circulation & cardiovascular health

Free of: Sugar, Salt, Dairy, Eggs, Peanuts, Tree Nuts, Fish, Shellfish, Yeast, Wheat, Gluten, Titanium Dioxide, Artificial Colors and Flavors.

General Statements

Visit NaturesLab.com to learn more.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 capsule one time daily, preferably with a meal, or as directed by a qualified healthcare practitioner.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nattokinase 2,000 FU by Nature's Lab label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nattokinase 2,000 FU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nattokinase 2,000 FU by Nature's Lab

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Nattokinase

Interacts with
289 drugs
100 mg per serving Form: Natto Extract

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Other (inactive) ingredients: Rice Flour, Hypromellose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nattokinase 2,000 FU by Nature's Lab Drug Interactions

Want to check YOUR meds against Nattokinase 2,000 FU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Nattokinase 2,000 FU interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nattokinase 2,000 FU interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Nattokinase 2,000 FU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nattokinase 2,000 FU, from the product label.

Nature's Lab

See all Nature's Lab products
Name
Nature's Lab
Street Address
6980 W. Warm Springs Rd. Ste. 100
City
Las Vegas
State
NV
ZipCode
89113
Phone Number
1-800-211-4188
Web Address
NaturesLab.com
Pharmacist Counseling Corner

Nattokinase 2,000 FU by Nature's Lab: Common Questions

Does Nattokinase 2,000 FU by Nature's Lab interact with any medications?
Yes. Based on its ingredients, Nattokinase 2,000 FU has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nattokinase 2,000 FU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is nattokinase safe if I have a soy allergy?
Nattokinase is made from fermented soybeans, and there are documented cases of allergic reactions to it — including severe ones. If you have a soy allergy or have reacted to natto before, don't take this without talking to your doctor or pharmacist first.
Can I take this while pregnant or breastfeeding?
No — there isn't enough safety data during pregnancy, so it's best avoided. The same goes for breastfeeding. Talk to your doctor if you're considering it during either time.
What exactly is nattokinase?
It's an enzyme that comes from natto, which is fermented soybean. It works as a natural blood thinner, which is why it's marketed for heart health — but also why it can interact with your blood pressure and blood-thinning medications.
Does this actually work for heart health?
We don't have reliable evidence to say whether nattokinase works for angina, atherosclerosis, or cardiovascular disease. The research we hold rates it as insufficient evidence for those uses. If you're interested, ask your doctor or pharmacist what other research suggests.
Are there any side effects I should know about?
It's generally well tolerated, but rare cases of bleeding — including serious bleeding in the brain — have been reported, especially when combined with other blood thinners like aspirin. If you have any bleeding risk, check with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nattokinase 2,000 FU is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nattokinase 2,000 FU label
Go deeper

The Full Monographs Behind Nattokinase 2,000 FU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Nattokinase 2,000 FU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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