Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

IGF-1 Ingredients & Drug Interactions

by Nature's Sunshine

IGF-1 label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking IGF-1 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

IGF-1 is a dietary supplement by Nature's Sunshine with 2 active ingredients. Its ingredients are commonly taken for sugar substitute / sweetener, blood sugar support in diabetes, weight management.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against IGF-1 by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with IGF-1 by Nature's Sunshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of IGF-1 by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This liquid product contains two active ingredients. Stevia leaf extract is a natural sweetener derived from the stevia plant and is used here as a sweetening agent.

IGF-1 is also present in the formula; we hold no further data on its role or activity. The product also contains several inactive ingredients — purified water, natural and artificial flavors, xylitol, citric acid, lecithin, and potassium sorbate — which serve as the liquid base, flavor, and preservation.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: anti-aging formula with energy and endurance.
  • We looked for evidence on: Age-related decline, Physical performance, Muscle recovery.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold on stevia leaf extract for any therapeutic use is insufficient to establish that it works. We have no rated effectiveness data for stevia in managing diabetes, high blood pressure, or weight, and we hold no effectiveness data for IGF-1.

The evidence, ingredient by ingredient Stevia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Purified stevia sweeteners at typical food amounts are generally recognized as safe. However, whole-leaf stevia and supplement doses—like the form in this product—are not well studied, so use caution.

At supplement doses, the safety is not as clear, and you should talk with your doctor or pharmacist if you have concerns. When taken by mouth, stevia and its active compounds are generally well tolerated.

The most common minor side effects—abdominal bloating, dizziness, headache, muscle pain, nausea, and numbness—usually go away after the first week. Muscle pain in particular tends to resolve within a week.

Allergic reactions are rare but possible. We hold no pregnancy or breastfeeding safety data for stevia or IGF-1 on file, so discuss this product with your doctor or pharmacist if you are pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Stevia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Stevia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take lithium, check with your doctor or pharmacist before starting—stevia might raise lithium levels, which could be serious. Also double-check if you're on blood pressure medications or diabetes medications, since stevia might lower blood pressure or blood sugar further.

We hold no interaction data for IGF-1 itself, so we cannot flag other concerns for that ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be of interest if you're looking for a stevia-sweetened supplement, but the evidence that stevia itself works for any health condition is not established in our data. The main caution is if you take lithium, blood pressure medications, or diabetes medications—those warrant a conversation with your doctor or pharmacist before you start, since stevia might affect how they work.

Check the interaction tool on this page with your exact medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about IGF-1, straight from the product label.

Brand Nature's Sunshine
Barcode (UPC) 099904009660
Net contents 1 fl. Oz.; 29.5 mL
Market status On market
Date entered into DSLD Apr 25, 2014
DSLD ID 32234
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for IGF-1 by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.32 mL
Maximum serving Sizes:
0.32 mL
Servings per container
90
UPC/BARCODE
099904009660
IngredientAmount% DV
Stevia leaf extract1.6 mg--
IGF-127 ng--

Other ingredients: purified Water, Natural and Artificial flavors, Xylitol, Citric Acid, Lecithin, Potassium Sorbate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Nature's Sunshine(R) QUALITY, SERVICE, INTEGRITY

General Statements

Since 1972

GUARANTEED PURE

- Anti-Aging Formula - Improves Energy & Endurance

A special extract of deer antler velvet.

Product of U.S.A.

LOT:

IGF-1 is produced in the body as a by-product of human growth hormone. IGF-1 is associated with muscle growth and increased energy. Also supports healthy joints and sexual performance. It boosts the immune system and has anti-aging properties.

General

Stock No. 966-1

Brand IP Statement(s)

(C) 2007

Formula

This extract comes from premium deer antler velvet and provides 2,500 nanograms per bottle of IGF-1 and other insulin-like growth factors.

Contains 2,500 n.g. per bottle of IGF-1, IGF-2 and other growth factors

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

RECOMMENDED USE Spray twice under the tongue, 3 times daily. Hold for 20 seconds before swallowing for best results. SHAKE WELL BEFORE USE

Precautions

Warning: Keep out of reach of children.

Cancer patients, diabetics, pregnant and lactating women should not take this product.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

IGF-1 by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

IGF-1 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in IGF-1 by Nature's Sunshine

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.32 mL Dosage formLiquid Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Stevia leaf extract

Interacts with
259 drugs
1.6 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia leaf extract monograph & interactions

IGF-1

27 ng per serving Form: Deer Antler Velvet extract

Other (inactive) ingredients: Purified Water, Natural and Artificial flavors, Xylitol, Citric Acid, Lecithin, Potassium Sorbate. These complete the product’s ingredient list but are not active constituents.

Interaction report

IGF-1 by Nature's Sunshine Drug Interactions

Want to check YOUR meds against IGF-1?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
1 Moderate 258 Minor

Ingredients driving the most interactions

Stevia leaf extract 259

Individual Drug Interactions

The ingredients in IGF-1 interact with 259 drugs. Click any drug to see the details.

1 of the 2 ingredients in IGF-1 interact with drugs. Each result below shows which ingredient is responsible. Stevia leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in IGF-1 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia leaf extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for IGF-1, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc.
City
Spanish Fork
State
UT
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

IGF-1 by Nature's Sunshine: Common Questions

Does IGF-1 by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, IGF-1 has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
IGF-1 contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the side effects of this product?
Most people tolerate it well. The most common mild side effects are bloating, dizziness, headache, muscle aches, nausea, and numbness—and these usually fade after your first week. Allergic reactions are rare. If anything bothers you, mention it to your pharmacist.
Can I take this if I'm on lithium?
Not without checking with your doctor first. Stevia in this product might reduce how your body clears lithium, which could raise it to unsafe levels. Your doctor needs to know before you start.
Does this product work for weight loss or diabetes?
We don't have enough reliable evidence to say stevia works for either. The research is mixed—some studies suggest it might help lower blood glucose, but others don't see a real effect.
Is this safe if I'm pregnant or breastfeeding?
We don't have safety data on file for either stevia or IGF-1 in pregnancy or lactation. Talk with your doctor or pharmacist for personalized advice before using this.
What does IGF-1 do in this product?
We hold no data on IGF-1's role or effects, so I can't tell you what it's meant to do here. Your pharmacist or the product's label may have more information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if IGF-1 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

IGF-1 label
Go deeper

The Full Monographs Behind IGF-1’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph →
Sources

Sources & How We Checked

IGF-1's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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