Wild Yam & Chaste Tree Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Wild Yam & Chaste Tree against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Wild Yam & Chaste Tree is a dietary supplement by Nature's Sunshine with 3 active ingredients. Its ingredients are commonly taken for premenstrual syndrome (pms), irregular or absent menstrual periods, cyclical breast pain (mastalgia).Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chaste Tree berry extract, Wild Yam root and root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Wild Yam & Chaste Tree by Nature's Sunshine
Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Yam & Chaste Tree by Nature's Sunshine — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Wild Yam & Chaste Tree by Nature's Sunshine
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product has three active ingredients. Wild yam root and root extract is the one we can fully assess; the proprietary blend and chaste tree berry extract make up the rest, though we don't have detailed interaction data for those two.
The inactive ingredients are cellulose, magnesium stearate, stearic acid, and the capsule itself.
Does it work?
Leans against
The evidence for wild yam in this product is limited. For menopausal symptoms, it's rated possibly ineffective.
For gallbladder disease, sexual dysfunction, painful periods (dysmenorrhea), and infertility, there isn't enough reliable evidence to rate it either way. The data we have doesn't establish that this product works for any of those conditions.
How safe is it?
Well-documented data
Wild yam is generally well tolerated when taken orally in the short term, though headache, fever, upset stomach, and vomiting have been reported—especially at higher doses. Anaphylaxis is rare but documented.
Long-term safety hasn't been well studied. The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know it's safe in those situations.
Meds to double-check
Moderate interaction found
Before you take Wild Yam & Chaste Tree, check whether you're on any estrogen-based medications (hormone therapy, birth control pills, or estrogen replacement). Wild yam may change how those work.
We weren't able to check the proprietary blend or chaste tree berry extract, so if you take other medications, use the search tool on this page.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product might be worth a conversation with your pharmacist if you're interested in herbal support and don't take estrogen-based medications. If you're on hormone therapy, birth control, or any other prescription, check it here first.
Pregnant or nursing? Avoid this one—the data isn't there to say it's safe.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Wild Yam & Chaste Tree, straight from the product label.
| Brand | Nature's Sunshine |
|---|---|
| Market status | On market |
| Date entered into DSLD | Jan 25, 2012 |
| DSLD ID | 5517 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult Female (18 - 50 Years), Menopause |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Wild Yam & Chaste Tree by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 210 mg | -- |
| Chaste Tree berry extract | 0 NP | -- |
| Wild Yam root and root extract | 0 NP | -- |
Other ingredients: Cellulose, Capsule, Magnesium Stearate, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Each packet of Natural Changes contain: C-X (2) capsules designed to provide herbal support for reproductive glands of mature women. Wild Yam & Chaste Tree (1 capsule) historically use by women during menopause. Super GLA (1 capsule) provides essential Omega 3/6/9 fatty acids, that support the female reproductive system. Skeletal Strength and Nutri-Calm (1 tablet each) designed to support healthy bones and a stressed nervous system.*
Wild Yam & Chaste Tree
This package contains 42 packets with five different herbal and nutrient combinations in each packet. Each packet contains a unique combination of vital nutrients to help provide nutritional support for women going through natural changes as they age.*
4 CAPSULES AND 2 TABLETS EACH
A Twenty-one Day Nutritional Support Program for Women
During menopause, the body requires more of certain nutrients than other times in life. Natural Changes will assist Mother Nature in providing those necessary nutrients without harmful side effects. Natural Changes contains a unique combination of nutrients to gently replenish the body's supply of essential hormones and health-balancing compounds that are used by the female glandular system during natural changes.*
Each packet of Natural Changes contain: C-X (2) capsules designed to provide herbal support for reproductive glands of mature women. Wild Yam & Chaste Tree (1 capsule) historically used by women during menopause. Super GLA (1 capsule) provides essential Omega 3/6/9 fatty acids, that support the female reproductive system. Skeletal Strength and Nutri-Calm (1 tablet each) designed to support healthy bones and a stressed nervous system.*
Herb Specialists Since 1972
Inner packets are not intended or labeled for individual retail sale.
Menopause & Glandular System Support
Nature's Sunshine uses natural source materials in its products that are subject to color variation.
Brand IP Statement(s)
(C)2011
Seals/Symbols
QUALITY, SERVICE, INTEGRITY
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommended Use: Take the contents of one packet with the morning meal and another packet with the evening meal. Drink one glass (8 ounces) of purified water with each packet. This represents a 21 day supply.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
This carton was sealed for your protection. Do not use if outer shrink wrap is missing or damaged. Nature's Sunshine uses natural source materials in its products that are subject to color variation.
General
Stock No. 4106-4
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Wild Yam & Chaste Tree by Nature's Sunshine label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Wild Yam & Chaste Tree by Nature's Sunshine
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Chaste Tree berry extract
Interacts with121 drugs
Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...
Chaste Tree berry extract monograph & interactionsWild Yam root and root extract
Interacts with41 drugs
Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...
Wild Yam root and root extract monograph & interactionsOther (inactive) ingredients: Cellulose, Capsule, Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
Wild Yam & Chaste Tree by Nature's Sunshine Drug Interactions
HelloPharmacist Interaction Report
Wild Yam & Chaste Tree by Nature's Sunshine includes wild yam, which can interact with estrogens (hormone medications).
Wild yam shows both estrogenic and anti-estrogenic effects, so it might increase or decrease how your estrogen therapy works — this is a Moderate-severity concern. We weren't able to check the proprietary blend or chaste tree berry extract for interactions, so their safety profile with medications isn't documented in our data.
Altogether, these interactions span 41 individual medications. Run your exact prescription medications through the checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Wild Yam & Chaste Tree?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Wild Yam & Chaste Tree interact with 121 drugs. Click any drug to see the details.
2 of the 3 ingredients in Wild Yam & Chaste Tree interact with drugs. Each result below shows which ingredient is responsible. Chaste Tree berry extract Wild Yam root and root extract
AcepromazineAtravet
How Acepromazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Acepromazine interactionAcetophenazineTindal
How Acetophenazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Acetophenazine interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Amitriptyline, Perphenazine interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berry Extract + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berry Extract + Apomorphine Hydrochloride interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Aripiprazole Lauroxil interactionArmodafinilNuvigil
How Armodafinil interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berry Extract + Armodafinil interactionAsenapineSaphris, Secuado
How Asenapine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Asenapine interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berry ExtractEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berry Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionWild Yam Root And Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root And Root Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionBenserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berry Extract + Benserazide, Levodopa interactionBirth Control PillsBirth control pills
How Birth Control Pills interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractContraceptive Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Read the full Chaste Tree Berry Extract + Birth Control Pills interactionBrexpiprazoleRexulti
How Brexpiprazole interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs, Dopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Brexpiprazole interactionBromocriptineParlodel
How Bromocriptine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berry Extract + Bromocriptine interactionButaperazineRepoise
How Butaperazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Butaperazine interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berry Extract + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berry Extract + Carbidopa, Levodopa, Entacapone interactionCariprazine HydrochlorideVraylar
How Cariprazine Hydrochloride interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Cariprazine Hydrochloride interactionCarphenazineProketazin
How Carphenazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Carphenazine interactionChlorpromazineThorazine, Thorazine Spansules
How Chlorpromazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Chlorpromazine interactionChlorprothixeneTaractan
How Chlorprothixene interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Chlorprothixene interactionClozapineClozaril, Versacloz
How Clozapine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Clozapine interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berry ExtractEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berry Extract + Conjugated Estrogens interactionWild Yam Root And Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root And Root Extract + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berry ExtractEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berry Extract + Conjugated Estrogens, Medroxyprogesterone Acetate interactionWild Yam Root And Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root And Root Extract + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berry ExtractEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berry Extract + Conjugated Estrogens, Meprobamate interactionWild Yam Root And Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root And Root Extract + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berry ExtractEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berry Extract + Conjugated Estrogens, Methyltestosterone interactionWild Yam Root And Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root And Root Extract + Conjugated Estrogens, Methyltestosterone interactionCyamemazineTercian
How Cyamemazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berry Extract + Cyamemazine interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berry ExtractEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berry Extract + Cyproterone Acetate, Ethinyl Estradiol interactionWild Yam Root And Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root And Root Extract + Cyproterone Acetate, Ethinyl Estradiol interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berry ExtractContraceptive Drugs, Estrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Read the full Chaste Tree Berry Extract + Desogestrel, Ethinyl Estradiol interactionWild Yam Root And Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root And Root Extract + Desogestrel, Ethinyl Estradiol interactionDopamineIntropin
How Dopamine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berry ExtractDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berry Extract + Dopamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Wild Yam & Chaste Tree with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Chaste Tree berry extract
Antipsychotic Drugs
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.
Contraceptive Drugs
Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.
Dopamine Agonists
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.
Estrogens
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.
Metoclopramide (Reglan)
Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.
Wild Yam root and root extract
Estrogens
Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.
Brand information
Manufacturer and brand details for Wild Yam & Chaste Tree, from the product label.
Nature's Sunshine
See all Nature's Sunshine products- Name
- Nature's Sunshine Products, Inc
- City
- Spanish Fork
- State
- Utah
- ZipCode
- 84660
- Phone Number
- 1-800-223-8225
- Web Address
- www.naturessunshine.com
Wild Yam & Chaste Tree by Nature's Sunshine: Common Questions
Does Wild Yam & Chaste Tree by Nature's Sunshine interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help with hot flashes or other menopausal symptoms?
Can I take this if I'm on birth control or hormone replacement therapy?
Is it safe to take long-term?
What side effects might I experience?
Can I take this while pregnant or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Wild Yam & Chaste Tree is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Wild Yam & Chaste Tree’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitex Agnus-castus
Interacts with 121 drugsVitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...
Read the full Vitex Agnus-castus monograph → Herb & supplement monographWild Yam
Interacts with 41 drugsWild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...
Read the full Wild Yam monograph →Sources & How We Checked
Wild Yam & Chaste Tree's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitex Agnus-castus 23 references
- Wuttke W. Dopaminergic action of extracts of Agnus Castus. Forschende Komplementarmedizen 1996;3:329-30.
- Jarry H, Leonhardt S., Gorkow C, Wuttke W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus Castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol 1994;102:448- PubMed
- Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo-controlled study. BMJ 2001;322:134-7. PubMed
- Lauritzen CH, Reuter HD, Repges R, et al. Treatment of premenstrual tension syndrome with Vitex agnus castus: Controlled-double blind versus pyridoxine. Phytomedicine 1997;4:183-9.
- Berger D, Schaffner W, Schrader E, et al. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with premenstrual syndrome (PMS). Arch Gynecol Obstet 2000;264:150-3.
- Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med 2000;9:315-20. PubMed
- Meier B, Berger D, Hoberg E, et al. Pharmacological activities of Vitex agnus-castus extracts in vitro. Phytomedicine 2000;7:373-81. PubMed
- Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472-9.. PubMed
- Wuttke W, Jarry H, Christoffel V, et al. Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine 2003;10:348-57. PubMed
- Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol 2003;18:191-5..
- Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf 2005;28:319-32..
- Halaska M, Beles P, Gorkow C, Sieder C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract: results of a placebo-controlled double-blind study. Breast 1999;8:175-81. PubMed
- Prilepskaya VN, Ledina AV, Tagiyeva AV, Revazova FS. Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome. Maturitas 2006;55 Suppl 1:S55-63. DOI
- Ma, L., Lin, S., Chen, R., and Wang, X. Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Gynecol.Endocrinol. 2010;26(8):612-616. PubMed
- Ma, L., Lin, S., Chen, R., Zhang, Y., Chen, F., and Wang, X. Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Aust.N.Z.J Obstet.Gynaecol. 2010;50(2):189-193. PubMed
- Dinç T, Coskun F. Comparison of fructus agni casti and flurbiprofen in the treatment of cyclic mastalgia in premenopausal women. Ulus Cerrahi Derg. 2014 Mar 1;30(1):34-8 PubMed
- Momoeda M, Sasaki H, Tagashira E, Ogishima M, Takano Y, Ochiai K. Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospective, open-label study. Adv Ther. 2014 Mar;31(3):362-73. PubMed
- Yavarikia P, Shahnazi M, Hadavand Mirzaie S, Javadzadeh Y, Lutfi R. Comparing the effect of mefenamic Acid and vitex agnus on intrauterine device induced bleeding. J Caring Sci. 2013 Aug 31;2(3):245-54.
- Van Die MD, Burger HC, Teede HG, Bone KM. Vitex agnus castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Med 2013:79:562-575. PubMed
- Ooi SL, Watts S, McClean R, Pak SC. Vitex agnus-castus for the treatment of cyclic mastalgia: A systematic review and meta-analysis. J Womens Health (Larchmt). 2020;29(2):262-278. PubMed
- Mollazadeh S, Mirghafourvand M, Abdollahi NG. The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis. J Complement Integr Med. 2019;17(1). pii: /j/jcim.2019.17.issue-1/jcim-2018-0053/jcim-2018-0053.xml.
- Najib FS, Poordast T, Mahmudi MS, Shiravani Z, Namazi N, Omrani GR. Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety. J Pharmacopuncture 2022;25(2):106-113. PubMed
- Somuncu E, Solak IHA. Colonic Obstruction Secondary to Phytobezoar Caused by Vitex Agnus-Castus Seeds: A Case Report. J Coll Physicians Surg Pak 2022;32(8):S115-S117. PubMed
Wild Yam 7 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
- Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
- Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
- Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
- Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
- Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC