Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Wild Yam & Chaste Tree Ingredients & Drug Interactions

by Nature's Sunshine

Wild Yam & Chaste Tree label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Yam & Chaste Tree against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Yam & Chaste Tree is a dietary supplement by Nature's Sunshine with 3 active ingredients. Its ingredients are commonly taken for premenstrual syndrome (pms), irregular or absent menstrual periods, cyclical breast pain (mastalgia).Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chaste Tree berry extract, Wild Yam root and root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Yam & Chaste Tree by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Yam & Chaste Tree by Nature's Sunshine — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Yam & Chaste Tree by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.

This product contains 3 active ingredients. Chaste tree berry extract (also called vitex) and wild yam root and root extract are the two named actives; they're combined with a proprietary blend you'll see listed on the label but whose exact composition we can't break down for you.

The inactive ingredients are cellulose, a capsule, magnesium stearate, and stearic acid — common fillers and binders.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: herbal support for women during menopause.
  • We looked for evidence on: Menopausal symptoms, hot flashes, night sweats, hormonal balance.
  • The closest evidence on file: Wild Yam is rated "Possibly Ineffective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Vitex Agnus-castus is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms.

Chaste tree berry extract is possibly effective for premenstrual syndrome (PMS) and breast tenderness (mastalgia), based on available evidence. For aging skin, anxiety, and premenstrual dysphoric disorder (PMDD), the evidence isn't established in our data — we simply don't have enough reliable information to rate it one way or the other.

Wild yam appears possibly ineffective for menopausal symptoms. For gallbladder disease, sexual dysfunction, menstrual cramps, and infertility, the evidence we hold on wild yam is insufficient to say whether it works.

The evidence, ingredient by ingredient Vitex Agnus-castus Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both chaste tree and wild yam are generally well tolerated in the short term. Chaste tree may cause diarrhea, fatigue, headache, insomnia, irregular menstruation, nausea, stomach pain, vomiting, and skin irritation; irregular or prolonged bleeding has also been reported.

Wild yam commonly causes fever, headache, upset stomach, and vomiting, and rarely can trigger anaphylaxis (a severe allergic reaction). Because chaste tree affects hormones, use it only under professional guidance.

The facts advise against chaste tree during pregnancy and breastfeeding due to possible hormonal effects and limited safety data. For wild yam, there isn't enough safety information — avoid it during pregnancy and breastfeeding and talk with your doctor or pharmacist about its use.

Side effects, ingredient by ingredient Vitex Agnus-castus Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitex Agnus-castus, Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you use any estrogen-based medications (birth control pills, hormone replacement therapy), antipsychotic drugs, dopamine agonists, or metoclopramide (Reglan). All are listed as Moderate-severity interactions with the chaste tree or wild yam in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with PMS and breast tenderness if chaste tree is your main interest. If you take birth control, hormone therapy, antipsychotic or anti-nausea medications, or dopamine-boosting drugs, you'll want to check with your doctor or pharmacist first — the interactions are real and could affect how your medications work.

Avoid it during pregnancy and breastfeeding. Run your full medication list through the tool on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Yam & Chaste Tree, straight from the product label.

Brand Nature's Sunshine
Market status On market
Date entered into DSLD Jan 25, 2012
DSLD ID 5517
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Menopause
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Yam & Chaste Tree by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Proprietary Blend210 mg--
Chaste Tree berry extract0 NP--
Wild Yam root and root extract0 NP--

Other ingredients: Cellulose, Capsule, Magnesium Stearate, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Each packet of Natural Changes contain: C-X (2) capsules designed to provide herbal support for reproductive glands of mature women. Wild Yam & Chaste Tree (1 capsule) historically use by women during menopause. Super GLA (1 capsule) provides essential Omega 3/6/9 fatty acids, that support the female reproductive system. Skeletal Strength and Nutri-Calm (1 tablet each) designed to support healthy bones and a stressed nervous system.*

Wild Yam & Chaste Tree

This package contains 42 packets with five different herbal and nutrient combinations in each packet. Each packet contains a unique combination of vital nutrients to help provide nutritional support for women going through natural changes as they age.*

4 CAPSULES AND 2 TABLETS EACH

A Twenty-one Day Nutritional Support Program for Women

During menopause, the body requires more of certain nutrients than other times in life. Natural Changes will assist Mother Nature in providing those necessary nutrients without harmful side effects. Natural Changes contains a unique combination of nutrients to gently replenish the body's supply of essential hormones and health-balancing compounds that are used by the female glandular system during natural changes.*

Each packet of Natural Changes contain: C-X (2) capsules designed to provide herbal support for reproductive glands of mature women. Wild Yam & Chaste Tree (1 capsule) historically used by women during menopause. Super GLA (1 capsule) provides essential Omega 3/6/9 fatty acids, that support the female reproductive system. Skeletal Strength and Nutri-Calm (1 tablet each) designed to support healthy bones and a stressed nervous system.*

Herb Specialists Since 1972

Inner packets are not intended or labeled for individual retail sale.

Menopause & Glandular System Support

Nature's Sunshine uses natural source materials in its products that are subject to color variation.

Brand IP Statement(s)

(C)2011

Seals/Symbols

QUALITY, SERVICE, INTEGRITY

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: Take the contents of one packet with the morning meal and another packet with the evening meal. Drink one glass (8 ounces) of purified water with each packet. This represents a 21 day supply.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

This carton was sealed for your protection. Do not use if outer shrink wrap is missing or damaged. Nature's Sunshine uses natural source materials in its products that are subject to color variation.

General

Stock No. 4106-4

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Yam & Chaste Tree by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Yam & Chaste Tree label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Yam & Chaste Tree by Nature's Sunshine

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

210 mg per serving

Chaste Tree berry extract

Interacts with
121 drugs
0 NP per serving

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...

Chaste Tree berry extract monograph & interactions

Wild Yam root and root extract

Interacts with
41 drugs
0 NP per serving

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam root and root extract monograph & interactions

Other (inactive) ingredients: Cellulose, Capsule, Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Yam & Chaste Tree by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Wild Yam & Chaste Tree?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Chaste Tree berry extract 121
Wild Yam root and root extract 41

Individual Drug Interactions

The ingredients in Wild Yam & Chaste Tree interact with 121 drugs. Click any drug to see the details.

2 of the 3 ingredients in Wild Yam & Chaste Tree interact with drugs. Each result below shows which ingredient is responsible. Chaste Tree berry extract Wild Yam root and root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Yam & Chaste Tree with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chaste Tree berry extract5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Chaste Tree berry extract full monograph & interactions

Wild Yam root and root extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam root and root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Yam & Chaste Tree, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc
City
Spanish Fork
State
Utah
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Wild Yam & Chaste Tree by Nature's Sunshine: Common Questions

Does Wild Yam & Chaste Tree by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Wild Yam & Chaste Tree has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Yam & Chaste Tree contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my birth control pills?
Not without checking first. Chaste tree and wild yam both have moderate interactions with contraceptive drugs — they may interfere with how well your birth control works. Talk to your doctor or pharmacist before starting this product.
Is it safe to use while I'm pregnant?
The facts advise against chaste tree during pregnancy due to possible hormonal effects and limited safety data. Wild yam also doesn't have enough safety information, so avoid it too. Talk with your doctor or pharmacist if you're pregnant or planning to be.
What side effects might I experience?
Chaste tree commonly causes irregular menstruation, nausea, headache, fatigue, diarrhea, stomach pain, and vomiting; skin irritation and changes in menstrual bleeding have also been reported. Wild yam may bring on fever, headache, upset stomach, and vomiting. Rarely, wild yam can cause anaphylaxis (a severe allergic reaction).
Does this actually work for PMS?
Chaste tree berry extract is possibly effective for PMS and breast tenderness based on available evidence. The evidence for wild yam on other conditions in this product — menopausal symptoms, sexual dysfunction, menstrual cramps, infertility — is either insufficient to rate or suggests it doesn't work (menopausal symptoms).
Can I breastfeed while taking this?
No. Chaste tree may influence milk-related hormones and its safety during breastfeeding is unclear, so it's not recommended. Wild yam also doesn't have enough safety data. Talk to your doctor or pharmacist for personalized advice.
What is the proprietary blend and why can't you tell me what's in it?
The label lists a proprietary blend, which means the manufacturer keeps the exact composition and amounts private — we have no data on what's actually in it, so we can't check it for interactions. Ask the maker directly if you want those details, or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Yam & Chaste Tree is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Yam & Chaste Tree label
Go deeper

The Full Monographs Behind Wild Yam & Chaste Tree’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Wild Yam & Chaste Tree's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitex Agnus-castus 23 references
  1. Wuttke W. Dopaminergic action of extracts of Agnus Castus. Forschende Komplementarmedizen 1996;3:329-30.
  2. Jarry H, Leonhardt S., Gorkow C, Wuttke W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus Castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol 1994;102:448- PubMed
  3. Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo-controlled study. BMJ 2001;322:134-7. PubMed
  4. Lauritzen CH, Reuter HD, Repges R, et al. Treatment of premenstrual tension syndrome with Vitex agnus castus: Controlled-double blind versus pyridoxine. Phytomedicine 1997;4:183-9.
  5. Berger D, Schaffner W, Schrader E, et al. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with premenstrual syndrome (PMS). Arch Gynecol Obstet 2000;264:150-3.
  6. Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med 2000;9:315-20. PubMed
  7. Meier B, Berger D, Hoberg E, et al. Pharmacological activities of Vitex agnus-castus extracts in vitro. Phytomedicine 2000;7:373-81. PubMed
  8. Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472-9.. PubMed
  9. Wuttke W, Jarry H, Christoffel V, et al. Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine 2003;10:348-57. PubMed
  10. Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol 2003;18:191-5..
  11. Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf 2005;28:319-32..
  12. Halaska M, Beles P, Gorkow C, Sieder C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract: results of a placebo-controlled double-blind study. Breast 1999;8:175-81. PubMed
  13. Prilepskaya VN, Ledina AV, Tagiyeva AV, Revazova FS. Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome. Maturitas 2006;55 Suppl 1:S55-63. DOI
  14. Ma, L., Lin, S., Chen, R., and Wang, X. Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Gynecol.Endocrinol. 2010;26(8):612-616. PubMed
  15. Ma, L., Lin, S., Chen, R., Zhang, Y., Chen, F., and Wang, X. Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Aust.N.Z.J Obstet.Gynaecol. 2010;50(2):189-193. PubMed
  16. Dinç T, Coskun F. Comparison of fructus agni casti and flurbiprofen in the treatment of cyclic mastalgia in premenopausal women. Ulus Cerrahi Derg. 2014 Mar 1;30(1):34-8 PubMed
  17. Momoeda M, Sasaki H, Tagashira E, Ogishima M, Takano Y, Ochiai K. Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospective, open-label study. Adv Ther. 2014 Mar;31(3):362-73. PubMed
  18. Yavarikia P, Shahnazi M, Hadavand Mirzaie S, Javadzadeh Y, Lutfi R. Comparing the effect of mefenamic Acid and vitex agnus on intrauterine device induced bleeding. J Caring Sci. 2013 Aug 31;2(3):245-54.
  19. Van Die MD, Burger HC, Teede HG, Bone KM. Vitex agnus castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Med 2013:79:562-575. PubMed
  20. Ooi SL, Watts S, McClean R, Pak SC. Vitex agnus-castus for the treatment of cyclic mastalgia: A systematic review and meta-analysis. J Womens Health (Larchmt). 2020;29(2):262-278. PubMed
  21. Mollazadeh S, Mirghafourvand M, Abdollahi NG. The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis. J Complement Integr Med. 2019;17(1). pii: /j/jcim.2019.17.issue-1/jcim-2018-0053/jcim-2018-0053.xml.
  22. Najib FS, Poordast T, Mahmudi MS, Shiravani Z, Namazi N, Omrani GR. Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety. J Pharmacopuncture 2022;25(2):106-113. PubMed
  23. Somuncu E, Solak IHA. Colonic Obstruction Secondary to Phytobezoar Caused by Vitex Agnus-Castus Seeds: A Case Report. J Coll Physicians Surg Pak 2022;32(8):S115-S117. PubMed

See these in context on the Vitex Agnus-castus monograph →

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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