Intolerance Complex Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Intolerance Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Intolerance Complex is a dietary supplement by Enzyme Science with 14 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Intolerance Complex by Enzyme Science
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Intolerance Complex contains 14 active enzymes that work together to break down different parts of food. Protease breaks down proteins; Lipase handles fats; Lactase breaks down milk sugar (lactose); Amylase and Glucoamylase work on starches; and the others target fiber, complex carbohydrates, and other compounds your digestive tract may struggle with.
The capsule also contains two inactive ingredients: hydroxypropyl methylcellulose (the capsule material) and water.
Does it work?
Strong evidence
Lactase in this formula is effective for lactose intolerance—that is, difficulty digesting milk sugar. For the other enzymes, the evidence we hold rates them as having insufficient reliable evidence to say whether they work for inflammatory bowel disease (Protease and Lipase), general indigestion (Lipase), or other digestive complaints.
If you're considering this product for something other than lactose intolerance, talk with your pharmacist about what the science actually shows.
How safe is it?
Well-documented data
The three enzymes we have safety data for are generally well tolerated by most adults. Protease and Lipase may cause digestive upset in some people, and there's a rare possibility of allergic reaction to protease (which is an occupational hazard in detergent manufacturing—exposure in everyday life is very different).
Lactase has caused contact allergies in workers handling the powder, but that's not the same risk as taking it by mouth. For pregnancy, the data is sparse: Lactase is likely safe, but Protease should be avoided unless prescribed by your doctor, and Lipase should only be used if your doctor advises it.
During breastfeeding, Protease and Lipase are not recommended without medical advice; Lactase may be okay to discuss with your healthcare provider first. We hold no safety data for the other 11 ingredients.
Meds to double-check
No known interactions
No interactions are documented in our data for the three enzymes we could check. However, we hold no interaction data for 11 of the 14 ingredients, so please use the medication checker on this page with your exact prescriptions before adding this product.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
If you have trouble digesting lactose, this product's Lactase is a proven option. If you're taking it for other digestive issues, the science is still thin—talk to your pharmacist about what's actually been tested.
Because we can't check 11 of the 14 enzymes and we don't know if you have any sensitivities to them, mention this product to your doctor or pharmacist before you start, especially if you're pregnant, breastfeeding, or managing a serious digestive condition.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Intolerance Complex, straight from the product label.
| Brand | Enzyme Science |
|---|---|
| Barcode (UPC) | 670480300107 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2025 |
| DSLD ID | 334827 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Intolerance Complex by Enzyme Science, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cellulase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Pectinase | 0 NP | -- |
| Maltase | 0 NP | -- |
| Dipeptidyl Peptidase-IV | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Amylase | 0 NP | -- |
| ATPro | 156 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Enzymes to target major food intolerances and macronutrients. Intolerance Complex delivers higher-potency digestive enzymes that target major food intolerances (including gluten, casein, lactose, phenol and complex carbohydrates) and macronutrients.
Kosher
Formulation
Helps the body break down food more efficiently. Delivers fast digestive relief for occasional bloating, gas and indigestion.
Specialized enzymes for food intolerances Targets gluten, dairy and phenols For occasional gas and bloating Macronutrient digestion
Vegan
Contains no: casein, crustaceans, eggs, fish, gluten, milk, nuts, sesame, shellfish, soy, wheat; artificial colors, fillers or flavors Non-GMO
Suggested/Recommended/Usage/Directions
Recommended Dose: 1-2 capsules per meal with the first bite of food. More may be taken as recommended by a healthcare practitioner.
Precautions
Do not use if safety seal is broken or missing.
Keep out of reach of children.
Storage
Keep closed in dry place; avoid excessive heat.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Scan for protocol Practitioner division of Enzymedica
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Intolerance Complex by Enzyme Science label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Intolerance Complex by Enzyme Science
These are the 14 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Cellulase
Hemicellulase
Invertase
Xylanase
Pectinase
Maltase
Dipeptidyl Peptidase-IV
Alpha-Galactosidase
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsLipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsLactase
No knowninteractions
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...
Lactase monograph & interactionsGlucoamylase
Amylase
ATPro
Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Water. These complete the product’s ingredient list but are not active constituents.
Intolerance Complex by Enzyme Science Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Intolerance Complex. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Intolerance Complex, from the product label.
Enzyme Science
See all Enzyme Science products- Name
- Enzyme Science
- City
- Venice
- State
- FL
- ZipCode
- 34292
- Phone Number
- 855-281-7246
- Web Address
- EnzyScience.com
Intolerance Complex by Enzyme Science: Common Questions
Does Intolerance Complex by Enzyme Science interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help me digest foods I'm sensitive to?
Can I take this if I'm pregnant?
Is this safe while breastfeeding?
What's in this that I'm actually swallowing?
Could I be allergic to any of these enzymes?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Intolerance Complex is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Intolerance Complex’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
Intolerance Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC