Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Adaptodren Testosterone Booster Ingredients & Drug Interactions

by Betancourt Nutrition

Adaptodren Testosterone Booster label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Adaptodren Testosterone Booster against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Adaptodren Testosterone Booster is a dietary supplement by Betancourt Nutrition with 7 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 942 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D, Banaba Extract, Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Adaptodren Testosterone Booster by Betancourt Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Adaptodren Testosterone Booster by Betancourt Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Adaptodren Testosterone Booster by Betancourt Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Adaptodren has 7 ingredients total. The active ones are Vitamin B6, Vitamin B12, D-Aspartic Acid, Vitamin D, Protease (a digestive enzyme), a proprietary blend called Testosterone Advantage™, and Banaba Extract.

The remaining ingredients are inactive — gelatin, magnesium stearate, silicon dioxide, and food colorants (Red #40, Blue #1, Yellow #6) plus Candurin Silver for appearance.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: testosterone support and hormone health.
  • We looked for evidence on: Erectile dysfunction (ED), Athletic performance, Sexual function, Hormonal balance, Hypogonadism.
  • The closest evidence on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED).

The evidence for most ingredients in this product is limited or not established. Vitamin B6 and Vitamin B12 are both effective for treating deficiencies, but neither is established for testosterone support.

Vitamin D is effective for rickets and bone disease but not for testosterone. Banaba extract has insufficient reliable evidence for diabetes or prediabetes.

No effectiveness ratings are on file for D-Aspartic Acid, Protease, or Testosterone Advantage™, so we cannot tell you whether this product actually raises testosterone.

The evidence, ingredient by ingredient Vitamin B6 Vitamin B12 Vitamin D Proteolytic Enzymes (proteases) Banaba

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well tolerated at normal doses but can damage nerves (sensory neuropathy) at high doses, especially above 1,000 mg daily or over long periods. Some side effects include headache, nausea, and loss of appetite.

Vitamin B12 is very safe and generally well tolerated. Vitamin D is safe at recommended doses but can cause toxicity at very high doses, leading to high blood calcium and related symptoms.

Banaba is generally well tolerated in short-term studies, but long-term safety isn't established. Protease may cause digestive upset or allergic reactions in some people.

Side effects, ingredient by ingredient Vitamin B6 Vitamin B12 Vitamin D Proteolytic Enzymes (proteases) Banaba

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Vitamin B12, Vitamin D, Vitamin B6, Banaba.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 943 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Adaptodren, double-check with your pharmacist if you take antihypertensive drugs (blood pressure meds), seizure medications (phenytoin, phenobarbital), heart medications (amiodarone, digoxin, verapamil, diltiazem), antidiabetes drugs, or atorvastatin. Vitamin B6 and vitamin D interactions are the most serious.

If you take metformin for diabetes, let us know so we can flag the B12 effect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood pressure meds, seizure medications, heart rhythm drugs, or diabetes medications, check with your pharmacist before starting this product — several ingredients can interact. If you're thinking about this for testosterone support, know that the evidence for whether it actually works isn't established in our data.

Talk to your pharmacist or doctor about your specific medications and health goals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Adaptodren Testosterone Booster, straight from the product label.

Brand Betancourt Nutrition
Barcode (UPC) 857487003143
Net contents 147 Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2013
DSLD ID 18075
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Adaptodren Testosterone Booster by Betancourt Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Capsule(s)
Maximum serving Sizes:
7 Capsule(s)
Servings per container
21
UPC/BARCODE
857487003143
IngredientAmount% DV
Vitamin B650 mg2500%
Vitamin B12300 mcg5000%
D-Aspartic Acid3000 mg--
Vitamin D1000 IU250%
Protease800 mg--
Testosterone Advantage(TM)236 mg--
Banaba Extract100 mg--

Other ingredients: Gelatin, Vegetable Magnesium Stearate, Silicon Dioxide, Red #40, Candurin Silver, Blue #1, yellow #6

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Thanks to Betancourt's Adaptodren(TM), the return of the legendary hormone increasing supplements of the past has finally arrived. Research has demonstrated that D-Aspartic Acid is the testosterone increasing amino acid the supplement industry has been waiting for. Calcium Fructate is the newest testosterone maintaining agent that has been shown in a pilot clinical case study to increase serum and free testosterone in as little as 3 hours. Betancourt's award winning research lab has developed the ultimate testosterone increasing, performance enhancing compound by combining these two power house ingredients into one Adaptodren(TM) using Protease to increase protein metabolism and Corsolic Acid to promote carbohydrate utilization in the body. Betancourt's Testosterone Booster promotes protein metabolism to maximize fullness, energy, strength and promote a lean chiseled physique.*

Testosterone Advantage (US #5962049) is a trademark of and licensed exclusively from VDF FutureCeuticals, Inc., Momence, IL 60954

WHATEVER IT TAKES(R)

General Statements

RESEARCH D-Aspartic Acid increases Testosterone by 42% in just 12 days.* Enza Tapo, et al. The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reproductive Biology and Endocrinology 2009, 7:120 Corsolic Acid increases GLUT4 Translocation for Muscle.* Toshihiro Miura, et al. Corsolic Acid Induces GLUT4 Translocation in Genetically Type 2 Diabetic Mice. Biological & Pharmaceutical Bulletin, Vol. 27 (2004), No. 7 1103

Toll-free: 800-443-4153 - Phone: 305-593-9296 - Fax: 202-449-8275

4,136 mg per serving

PROMOTES INCREASES IN TESTOSTERONE, GLUT4 TRANSLOCATION, AND PROTEIN METABOLISM. * PRO-MUSCLE AMPLIFICATION*

Formula

Calcium Fructate increases serum and Free Testosterone.* Testosterone AdvantageTM promotes healthy blood testosterone levels in middle-aged men.

3,000 mg T-SHOT(TM): 100% D-ASPARTIC ACID 800 mg PROTEASE (5,000 HUT/G) 236 mg TESTOSTERONE ADVANTAGE(TM): CALCIUM FRUCTATE 100 mg BANABA EXTRACT (1% COROSOLIC ACID)

Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18.

Consult your physician before using this or any dietary supplement.

Do not use if you are pregnant, nursing, trying to conceive, taking mediation, have a medical condition or are currently unaware of your health status.

Storage

STORE IN A COOL DRY PLACE.

Seals/Symbols

LABORATORY TESTED BY nfn

FDA Disclaimer Statement

* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

RECOMMENDED USE Take 7 capsules per day in between meals (can be taken all at once or in two separate dosages of 3 and 4 capsules throughout the day). Use for cycles lasting 6-9 weeks; discontinue use for 4 weeks before repeating.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Adaptodren Testosterone Booster by Betancourt Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Adaptodren Testosterone Booster label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Adaptodren Testosterone Booster by Betancourt Nutrition

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Capsule(s) Dosage formCapsule Servings per container21 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
50 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Vitamin B12

Interacts with
20 drugs
300 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

D-Aspartic Acid

3000 mg per serving

Vitamin D

Interacts with
715 drugs
1000 IU per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Protease

No known
interactions
800 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Testosterone Advantage(TM)

236 mg per serving

Banaba Extract

Interacts with
299 drugs
100 mg per serving Form: Corosolic Acid

Banaba is a leaf extract most often used to help support healthy blood sugar, and small early studies suggest its active compound corosolic acid may m...

Banaba Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Vegetable Magnesium Stearate, Silicon Dioxide, Red #40, Candurin Silver, Blue #1, Yellow #6. These complete the product’s ingredient list but are not active constituents.

Interaction report

Adaptodren Testosterone Booster by Betancourt Nutrition Drug Interactions

Want to check YOUR meds against Adaptodren Testosterone Booster?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
942Drugs
350 Moderate 592 Minor

Ingredients driving the most interactions

Vitamin D 715
Banaba Extract 299
Vitamin B6 210
Vitamin B12 20

Individual Drug Interactions

The ingredients in Adaptodren Testosterone Booster interact with 942 drugs. Click any drug to see the details.

4 of the 7 ingredients in Adaptodren Testosterone Booster interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Banaba Extract Vitamin B6 Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Adaptodren Testosterone Booster with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Banaba Extract3 drug types · 299 drugs

Antidiabetes Drugs

Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.
Human and animal research suggests that banaba can lower blood glucose levels.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of banaba and antihypertensive drugs might cause additive effects.
Human and animal research suggests that banaba can lower blood pressure.

Likelihood Probable Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, concomitant use of banaba with substrates of OATP might reduce the bioavailability of the OATP substrate.
In vitro research shows that banaba inhibits OATP, particularly OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the absorption of drugs and other compounds.

Likelihood Possible Evidence D
Banaba Extract full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Adaptodren Testosterone Booster, from the product label.

Betancourt Nutrition

See all Betancourt Nutrition products
Name
Betancourt Nutrition, Inc.
Street Address
14620 NW 60th Ave.
City
Miami Lakes
State
FL
ZipCode
33014
Phone Number
800-443-4153
Web Address
www.betancourtnutrition.com
Pharmacist Counseling Corner

Adaptodren Testosterone Booster by Betancourt Nutrition: Common Questions

Does Adaptodren Testosterone Booster by Betancourt Nutrition interact with any medications?
Yes. Based on its ingredients, Adaptodren Testosterone Booster has a known interaction with 942 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Adaptodren Testosterone Booster contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is vitamin B6 in this product safe at this dose?
Vitamin B6 is well tolerated below 100 mg daily. We don't have the exact dose in Adaptodren, but high doses over time can cause nerve damage. If you're taking this long term, ask your pharmacist about the B6 amount and whether it's right for you.
Can I take this if I'm pregnant or nursing?
Vitamin B6 is rated possibly unsafe in pregnancy and should only be used under a doctor's guidance. Banaba should be avoided in pregnancy and lactation because safety isn't established. Talk with your OB or pharmacist before starting this product.
What does protease do in this supplement?
Protease is a digestive enzyme, but we have no effectiveness data for it in testosterone support. It may help with protein digestion, though some people experience digestive upset from it.
Does this actually boost testosterone?
The data we hold doesn't establish whether D-Aspartic Acid, the proprietary Testosterone Advantage™ blend, or Protease raise testosterone levels. The evidence just isn't there in our records.
Why is Vitamin D a concern if I'm on heart medication?
High doses of vitamin D can raise calcium levels in your blood, which interferes with how digoxin and certain other heart rhythm drugs work, and can dangerously increase your risk of abnormal heartbeats. That's why your doctor needs to know if you're taking high-dose vitamin D with those medications.
What if I take metformin for diabetes?
Metformin can lower your B12 levels over time. This product has B12 in it, which might help offset that, but talk to your doctor or pharmacist about whether you need separate B12 monitoring.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Adaptodren Testosterone Booster label
Go deeper

The Full Monographs Behind Adaptodren Testosterone Booster’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Banaba

Interacts with 299 drugs

Banaba is a leaf extract most often used to help support healthy blood sugar, and small early studies suggest its active compound corosolic acid may modestly lower glucose. The overall evide...

Read the full Banaba monograph →
Sources

Sources & How We Checked

Adaptodren Testosterone Booster's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 98 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
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Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
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Vitamin D 26 references
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  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
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  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
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Proteolytic Enzymes (proteases) 3 references
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Banaba 7 references
  1. Judy WV, Hari SP, Stogsdill WW, et al. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol 2003;87:115-7. PubMed
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  3. Fukushima, M., Matsuyama, F., Ueda, N., Egawa, K., Takemoto, J., Kajimoto, Y., Yonaha, N., Miura, T., Kaneko, T., Nishi, Y., Mitsui, R., Fujita, Y., Yamada, Y., and Seino, Y. Effect of corosolic acid on postchallenge plasma glucose levels. Diabetes Res C PubMed
  4. Yamaguchi, Y., Yamada, K., Yoshikawa, N., Nakamura, K., Haginaka, J., and Kunitomo, M. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci 11-25-2006;79(26):2474-2479. PubMed
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