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Dietary supplement

Iodoral IOD - 50 Ingredients & Drug Interactions

by Optimox Corporation

Iodoral IOD - 50 label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Iodoral IOD - 50 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Iodoral IOD - 50 is a dietary supplement by Optimox Corporation with 3 active ingredients. Its ingredients are commonly taken for preventing iodine deficiency, supporting thyroid hormone production, general energy and metabolism support.Based on those ingredients, 7 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Iodine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Iodoral IOD - 50 by Optimox Corporation

Ask about any prescription or over-the-counter medication and we check it for interactions with Iodoral IOD - 50 by Optimox Corporation — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Iodoral IOD - 50 by Optimox Corporation

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Iodoral IOD-50 contains 3 active ingredients: iodine and iodide (the two main forms of iodine in the supplement) and total iodide/iodine. Together they deliver a high-dose iodine supplement meant for specific medical uses.

The product also contains several inactive ingredients (micosolle, microcrystalline cellulose, vegetable stearins, and pharmaceutical glaze) that help form and coat the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: iodine deficiency and thyroid support.
  • We looked for evidence on: Iodine deficiency, Infant development, Prematurity, Radiation exposure, Thyroid cancer, thyroid function — and 1 related terms.
  • The strongest evidence on file: Iodine is rated "Likely Effective" for Radiation exposure (Natural Medicines).
  • Also on file: Iodine is rated "Likely Effective" for Iodine deficiency.
  • Also on file: Iodine is rated "Possibly Ineffective" for Prematurity.

Iodine in this product is likely effective for preventing thyroid problems after radiation exposure and for treating iodine deficiency. It's possibly effective for reducing inflammation in the mouth (oral mucositis) and gum disease (periodontitis), though the evidence is less established.

Because this is a high-dose iodine product, it's meant to be used under medical guidance for specific conditions, not as a routine supplement.

The evidence, ingredient by ingredient Iodine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Iodine is well tolerated at normal dietary amounts and when used therapeutically with proper monitoring. At high doses like those in this product, thyroid problems can develop.

Common side effects include stomach upset, diarrhea, nausea, headache, metallic taste, and goiter (thyroid enlargement). Rare serious reactions include hives, swelling, fever, and in very rare cases, severe allergic reactions.

If you take this product chronically or in large amounts, watch for acneform skin lesions (iododerma), which have been reported with very high iodine intake. For pregnancy and breastfeeding: adequate iodine matters for fetal development and infant health, but this is a high-dose product.

Use only the amount your doctor advises and avoid this product if you're looking for routine pregnancy supplementation. Some iodine passes into breast milk, so follow your doctor's guidance if nursing.

Side effects, ingredient by ingredient Iodine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Iodine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 7 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Iodoral IOD-50, check with your doctor or pharmacist if you take lithium, any antithyroid drugs (used for overactive thyroid), or amiodarone (Cordarone) for heart rhythm. All three have moderate interactions with the iodine in this product and require thyroid function monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Iodoral IOD-50 is a high-dose iodine supplement meant for specific medical conditions like radiation exposure or documented iodine deficiency, not routine use. If you take lithium, antithyroid drugs, or amiodarone, you'll need to talk with your doctor or pharmacist before adding this product because of moderate interactions affecting thyroid function.

Anyone considering it should check their exact medications first and discuss the need for thyroid monitoring with their healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Iodoral IOD - 50, straight from the product label.

Brand Optimox Corporation
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Apr 25, 2014
DSLD ID 32453
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Iodoral IOD - 50 by Optimox Corporation, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
IngredientAmount% DV
Iodine20 mg--
Total Iodide/Iodine50 mg33332%
Iodide30 mg--

Other ingredients: Micosolle, microcrystaline cellulose, Vegetable Stearins, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

SUGGESTED USE: Take one tablet per day or as directed by a physician.

Storage

Store in a cool, dry and dark place.

Formula

IOD - 50 High Potency Iodine/Potassium Iodide Containing 50 mg elemental Iodine per tablet

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Iodoral IOD - 50 by Optimox Corporation label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Iodoral IOD - 50 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Iodoral IOD - 50 by Optimox Corporation

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Iodine

Interacts with
7 drugs
20 mg per serving

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements...

Iodine monograph & interactions

Total Iodide/Iodine

50 mg per serving

Iodide

Interacts with
7 drugs
30 mg per serving Form: Potassium Salt

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements...

Iodide monograph & interactions

Other (inactive) ingredients: Micosolle, Microcrystaline cellulose, Vegetable Stearins, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Iodoral IOD - 50 by Optimox Corporation Drug Interactions

Want to check YOUR meds against Iodoral IOD - 50?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
7Drugs
7 Moderate

Ingredients driving the most interactions

Iodine 7

Individual Drug Interactions

The ingredients in Iodoral IOD - 50 interact with 7 drugs. Click any drug to see the details.

1 of the 3 ingredients in Iodoral IOD - 50 interact with drugs. Each result below shows which ingredient is responsible. Iodine

Each ingredient & the kinds of drugs it affects

For each ingredient in Iodoral IOD - 50 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Iodine3 drug types · 7 drugs

Amiodarone (Cordarone)

Combining iodine with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with iodine might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.

Likelihood Probable Evidence D
Antithyroid Drugs

Iodine might alter the effects of antithyroid drugs.
Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking iodine while using antithyroid drugs could alter the effects of the antithyroid drugs.

Likelihood Probable Evidence D
Lithium

Combining iodine with lithium might have additive hypothyroid effects.
Lithium can inhibit thyroid function. Several case reports suggest that concomitant use of lithium and potassium iodide can reduce thyroid function in otherwise healthy adults. Monitor thyroid function.

Likelihood Probable Evidence D
Iodine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Iodoral IOD - 50, from the product label.

Optimox Corporation

See all Optimox Corporation products
Name
Optimox Corporation
City
Torrance
State
CA
ZipCode
90510-3378
Pharmacist Counseling Corner

Iodoral IOD - 50 by Optimox Corporation: Common Questions

Does Iodoral IOD - 50 by Optimox Corporation interact with any medications?
Yes. Based on its ingredients, Iodoral IOD - 50 has a known interaction with 7 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Iodoral IOD - 50 contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is iodine in this supplement used for?
Iodine is likely effective for preventing thyroid problems after radiation exposure and for treating iodine deficiency. It's also possibly effective for reducing mouth inflammation (oral mucositis) and gum disease (periodontitis). This is a high-dose product meant for specific medical uses under a doctor's guidance, not everyday supplementation.
Can I take this if I'm pregnant or breastfeeding?
Iodine is important for fetal development and infant health, but Iodoral IOD-50 is a high-dose product. The safety data shows mixed ratings—some safety notes say likely safe, others say possibly unsafe. Because of the dose and the conflicting data, use only the amount your doctor specifically advises, and don't choose this product for routine pregnancy supplementation. Talk with your doctor about whether it's right for you.
What are the common side effects?
When taken by mouth, iodine at high doses can cause stomach upset, diarrhea, nausea, headache, metallic taste, and goiter (thyroid swelling). If you take it chronically or in very large amounts over time, you may develop acneform skin lesions. Rare serious reactions include hives, swelling, fever, and very rarely, severe allergic reactions.
Is this product safe if I take no medications?
Even without other medications, high-dose iodine can cause thyroid problems. Iodine is well tolerated at normal dietary amounts, but this supplement is formulated as a therapeutic high-dose product meant for specific conditions and medical monitoring. If you're considering it, talk with your doctor about whether you actually need it and whether your thyroid function should be checked.
Why is there a warning about lithium?
Lithium already slows down thyroid function, and iodine does too. Taking both together might worsen low thyroid function (hypothyroidism) and can happen even in otherwise healthy people. If you take lithium and want to use this supplement, your doctor will need to monitor your thyroid function closely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Iodoral IOD - 50 label
Go deeper

The Full Monographs Behind Iodoral IOD - 50’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Iodine

Interacts with 7 drugs

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements help when you are truly deficient, but...

Read the full Iodine monograph →
Sources

Sources & How We Checked

Iodoral IOD - 50's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Iodine 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Goodman GA, Rall TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics, 9th ed.
  3. Ghent WR, Eskin BA, Low DA, Hill LP. Iodine replacement in fibrocystic disease of the breast. Can J Surg 1993;36:453-60.
  4. Potassium iodide for nuclear exposure. Pharmacist's Letter/Prescriber's Letter 2001;17(12):171214.
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cabezas C, Bustamante B, Holgado W, Begue RE. Treatment of cutaneous sporotrichosis with one daily dose of potassium iodide. Pediatr Infect Dis J 1996;15:352-4. PubMed
  7. Sterling JB, Heymann WR. Potassium iodide in dermatology: a 19th century drug for the 21st century-uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol 2000;43:691-7. PubMed
  8. Yarrington CD, Pearce EN. Dietary iodine in pregnancy and postpartum. Clin Obstet Gynecol 2011;54:459-70. PubMed
  9. Goel, S., Mandhani, A., Srivastava, A., Kapoor, R., Gogoi, S., Kumar, A., and Bhandari, M. Is povidone iodine an alternative to silver nitrate for renal pelvic instillation sclerotherapy in chyluria? BJU.Int 2004;94(7):1082-1085. PubMed
  10. Teng, W., Shan, Z., Teng, X., Guan, H., Li, Y., Teng, D., Jin, Y., Yu, X., Fan, C., Chong, W., Yang, F., Dai, H., Yu, Y., Li, J., Chen, Y., Zhao, D., Shi, X., Hu, F., Mao, J., Gu, X., Yang, R., Tong, Y., Wang, W., Gao, T., and Li, C. Effect of iodine int
  11. Crawford, B. A., Cowell, C. T., Emder, P. J., Learoyd, D. L., Chua, E. L., Sinn, J., and Jack, M. M. Iodine toxicity from soy milk and seaweed ingestion is associated with serious thyroid dysfunction. Med J Aust. 10-4-2010;193(7):413-415. PubMed
  12. Ohkuma, M. Molluscum contagiosum treated with iodine solution and salicylic acid plaster. Int J Dermatol. 1990;29(6):443-445. PubMed
  13. Connelly KJ, Boston BA, Pearce EN, Sesser D, Snyder D, Braverman LE, Pino S, LaFranchi SH. Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion. J Pediatr. 2012 Oct;161(4):760-2. PubMed
  14. Kasahara T, Narumi S, Okasora K, Takaya R, Tamai H, Hasegawa T. Delayed onset congenital hypothyroidism in a patient with DUOX2 mutations and maternal iodine excess. Am J Med Genet A. 2013 Jan;161A(1):214-7.
  15. Murcia M, Rebagliato M, Iñiguez C, Lopez-Espinosa MJ, Estarlich M, Plaza B, Barona-Vilar C, Espada M, Vioque J, Ballester F. Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. Am J Epidemiol. 2011 Apr 1;173(7):8 PubMed
  16. Sang Z, Wang PP, Yao Z, Shen J, Halfyard B, Tan L, Zhao N, Wu Y, Gao S, Tan J, Liu J, Chen Z, Zhang W. Exploration of the safe upper level of iodine intake in euthyroid Chinese adults: a randomized double-blind trial. Am J Clin Nutr. 2012 Feb;95(2):367-73 PubMed
  17. Speeckaert MM, Speeckaert R, Wierckx K, Delanghe JR, Kaufman JM. Value and pitfalls in iodine fortification and supplementation in the 21st century. Br J Nutr. 2011 Oct;106(7):964-73. PubMed
  18. Yun SE, Kang Y, Bae EJ, Hwang K, Jang HN, Cho HS, Chang SH, Park DJ. Iodine-induced thyrotoxic hypokalemic paralysis after ingestion of Salicornia herbace. Ren Fail. 2014 Apr;36(3):461-3.
  19. Iodine Hypersensitivity. Pharmacist's Letter/Prescriber's Letter 2011; 27(5):270504.
  20. Hammel JA, Selby JC. Pustular eruption in a patient with cancer treated with complementary and alternative medicine. JAMA Dermatology 2017 October; E1. doi: 10.1001/jamadermatol.2017.3749. [Epub ahead of print] PubMed
  21. Gil GS, Smith BW, Guerra JR, Williams WT. Acute Delirium in a Hypothyroid Patient Precipitated by Iodine Supplements Use. Am J Ther. 2018;25(6):e717-e718. PubMed
  22. Hamby T, Kunnel N, Dallas JS, Wilson DP. Maternal iodine excess: an uncommon cause of acquired neonatal hypothyroidism. J Pediatr Endocrinol Metab. 2018;31(9):1061-1064. PubMed
  23. Censi S, Watutantrige-Fernando S, Groccia G, et al. The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine
  24. Rovner MS, Wolf BJ, Rubin M, et al. Instillation of 5% Povidone-Iodine Ophthalmic Drops Decreases the Respiratory Rate in Children Undergoing Strabismus Surgery: A Randomized Controlled Trial. J Pediatr Ophthalmol Strabismus. 2019;56(6):378-382. PubMed
  25. Guenezan J, Garcia M, Strasters D, et al. Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2021;147(4):400-401. PubMed
  26. Li F, Wan S, Zhang L, et al. A Meta-Analysis of the Effect of Iodine Excess on the Intellectual Development of Children in Areas with High Iodine Levels in their Drinking Water. Biol Trace Elem Res 2022;200(4):1580-1590. PubMed

See these in context on the Iodine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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