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Dietary supplement

Ivy Calm Ingredients & Drug Interactions

by Integrative Therapeutics

Ivy Calm label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ivy Calm against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ivy Calm is a dietary supplement by Integrative Therapeutics with 2 active ingredients. Its ingredients are commonly taken for cough and chest congestion, bronchitis, asthma symptoms.Based on those ingredients, 280 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are English Ivy (Hedera helix) Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ivy Calm by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Ivy Calm by Integrative Therapeutics — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of Ivy Calm by Integrative Therapeutics

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

None of the active ingredients could be matched to our evidence database, so the stated purpose can't be graded.

Why this rating?
  • The label markets this product for: support lung and bronchial passageway health.
  • We looked for evidence on: Bronchitis, Cough, Respiratory tract infections, Chest congestion, Asthma symptoms, Sore throat.
  • We couldn't match any of the active ingredients to a HelloPharmacist monograph, so there's no evidence data to grade that purpose against.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “English Ivy (Hedera helix) Leaf Extract” is listed as a grouped ingredient — the label gives one combined amount (33 mg) without saying how much of each component you get.
Known Interaction Concern
Not assessable

None of the active ingredients could be matched to our interaction database.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
Safety Information
Unable to assess

None of the active ingredients could be matched to our safety data.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.

Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ivy Calm, straight from the product label.

Brand Integrative Therapeutics
Net contents 3.4 fl. Oz.; 100 mL
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 24124
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegetarian, Adult (18 - 50 Years), Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ivy Calm by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 tsp
Maximum serving Sizes:
2 tsp
Servings per container
10
IngredientAmount% DV
Calories10 {Calories}--
Total Carbohydrates3 Gram(s)1%
Sugar1 Gram(s)--
English Ivy (Hedera helix) Leaf Extract33 mg--
standarized to contain 9 mg of hederacoside C9 mg--

Other ingredients: purified Water, Vegetable Glycerol, Fructose, Natural flavors, Sucrose Laurate, Potassium Sorbate, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

LI78771.03B

Manufactured by Max Zeller Schne, AG Product of Switzerland

LOT 100673 EXP 05 2013

This product contains natural ingredients; color variations are normal.

EVIDENCE-BASED

Seals/Symbols

VEGETARIAN

KIDSAFE!

Formula

Clinically studied syrup to support lung and bronchial passageway health in children and adults

General

LI78771.03F 4191603/10C

FDA Disclaimer Statement

THIS STATEMENT HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

Suggested/Recommended/Usage/Directions

Recommendations: Take two to six times per day, as needed. Adults: 2 tsp (10 mL). Children 6 years of age and older: 1-1/2 tsp (7.5 mL). Children 2 to 5 years of age: 1 tsp (5 mL).

Precautions

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

FDA Statement of Identity

Ivy Leaf Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ivy Calm by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ivy Calm label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ivy Calm by Integrative Therapeutics

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 tsp Dosage formLiquid Servings per container10 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

English Ivy (Hedera helix) Leaf Extract

Interacts with
280 drugs
33 mg per serving

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many...

English Ivy (Hedera helix) Leaf Extract monograph & interactions
  • › Standarized to contain 9 mg of hederacoside C

Other (inactive) ingredients: Purified Water, Vegetable Glycerol, Fructose, Natural flavors, Sucrose Laurate, Potassium Sorbate, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ivy Calm by Integrative Therapeutics Drug Interactions

Ivy Calm contains 2 ingredients, and 1 of them has known drug interactions. Altogether it interacts with 280 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Ivy Calm?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
280Drugs
280 Moderate

Ingredients driving the most interactions

English Ivy (Hedera helix) Leaf Extract 280

Individual Drug Interactions

The ingredients in Ivy Calm interact with 280 drugs. Click any drug to see the details.

1 of the 2 ingredients in Ivy Calm interact with drugs. Each result below shows which ingredient is responsible. English Ivy (Hedera helix) Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Ivy Calm with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

English Ivy (Hedera helix) Leaf Extract3 drug types · 280 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
In vitro research shows that English ivy inhibits CYP2C19 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.
In vitro research shows that English ivy inhibits CYP2C8 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
In vitro research shows that English ivy inhibits CYP2D6 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
English Ivy (Hedera helix) Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ivy Calm, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, Inc.
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1.800.931.1709
Web Address
www.integrativeinc.com
Pharmacist Counseling Corner

Ivy Calm by Integrative Therapeutics: Common Questions

Does Ivy Calm by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, Ivy Calm has a known interaction with 280 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ivy Calm contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ivy Calm is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ivy Calm label
Go deeper

The Full Monographs Behind Ivy Calm’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

English Ivy

Interacts with 280 drugs

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many European herbal products. Some research...

Read the full English Ivy monograph →
Sources

Sources & How We Checked

Ivy Calm's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

English Ivy 13 references
  1. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  2. Fazio S, Pouso J, Dolinsky D, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009;16 PubMed
  3. García M, Fernández E, Navarro JA, et al. Allergic contact dermatitis from Hedera helix L. Contact Dermatitis 1995;33(2):133-4.
  4. Hausen BM, Brohan J, Konig WA, et al. Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.). Contact Dermatitis 1987;17(1):1-9.
  5. Mitchell, J. C. Allergic contact dermatitis from Hedera helix and Brassaia actinophylla (Araliaceae). Contact Dermatitis 1981;7(3):158-159.
  6. Boyle J, Harman RM. Contact dermatitis to Hedera helix (common ivy). Contact Dermatitis 1985;12(2):111-112. PubMed
  7. Yesudian PD, Franks A. Contact dermatitis from Hedera helix in a husband and wife. Contact Dermatitis 2002;46(2):125-126.
  8. Bregnbak D, Menné T, Johansen JD. Airborne contact dermatitis caused by common ivy (Hedera helix L. ssp. helix). Contact Dermatitis. 2015;72(4):243-4.
  9. Jones JM, White IR, White JM, McFadden JP. Allergic contact dermatitis to English ivy (Hedera helix)--a case series. Contact Dermatitis. 2009 Mar;60(3):179-80.
  10. Lurquin E, Swinnen I, Goossens A. Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. Contact Dermatitis. 2012;66(6):352-3.
  11. Paulsen E, Christensen LP, Andersen KE. Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future. Contact Dermatitis. 2010;62(4):201-9.
  12. Rehman SU, Kim IS, Choi MS, Kim SH, Zhang Y, Yoo HH. Time-dependent Inhibition of CYP2C8 and CYP2C19 by Hedera helix Extracts, A Traditional Respiratory Herbal Medicine. Molecules. 2017;22(7). PubMed
  13. Kruttschnitt E, Wegener T, Zahner C, Henzen-Bücking S. Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis. Evid Based Complement Alternat Med. 2020 May 4;2

See these in context on the English Ivy monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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