Karela Capsules Ingredients & Drug Interactions
by Herbal Hills
What is this page for?
First and foremost: checking Karela Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Karela Capsules is a dietary supplement by Herbal Hills with 2 active ingredients. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 282 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Karela, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Karela Capsules by Herbal Hills
Ask about any prescription or over-the-counter medication and we check it for interactions with Karela Capsules by Herbal Hills — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Karela Capsules by Herbal Hills
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Karela Capsules contains 2 active ingredients: karela (bitter melon) powder and karela fruit extract powder. Karela is the whole plant used as a traditional remedy, often with a bitter taste — that's where the name comes from.
The extract is a concentrated form of the fruit. Both are forms of the same plant.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that bitter melon works for any of the conditions it's traditionally used for — amenorrhea, athletic performance, liver disease, constipation, diabetes, or indigestion all fall short of reliable proof. That doesn't mean it's ineffective, just that the data we have isn't strong enough to say either way.
How safe is it?
Well-documented data
When taken by mouth, bitter melon is generally well tolerated. The most common side effects are gastrointestinal — heartburn, nausea, vomiting, diarrhea, constipation, gas, and belly discomfort occur in about 3% to 16% of people in studies.
Dizziness, fatigue, and headache have also been reported. Rare cases of severe low blood sugar (hypoglycemic coma) and seizures in children have occurred, and one case report described kidney damage after high-dose extract use.
For pregnancy, the traditional view advises against it because bitter melon seeds and higher doses may trigger harmful effects on the uterus. For breastfeeding, there isn't enough reliable safety information, so it's best avoided.
If you're pregnant or breastfeeding, talk with your doctor or pharmacist before using this product.
Meds to double-check
Moderate interaction found
Check with your pharmacist before taking this product if you're on antidiabetes drugs (moderate risk of low blood sugar), medications that are P-glycoprotein substrates (moderate risk of increased levels), or pazopanib for cancer (moderate risk of increased levels). We also hold no interaction data for the ingredient Bitters, so mention that to your pharmacist too.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Karela Capsules might appeal to someone looking for a traditional remedy, but the science doesn't yet support its use for common conditions. If you take antidiabetes drugs, P-glycoprotein substrate medications, or pazopanib, you should check with your pharmacist first — the interaction risk is real and needs monitoring.
Anyone pregnant, breastfeeding, or on other medications should discuss this with their pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Karela Capsules, straight from the product label.
| Brand | Herbal Hills |
|---|---|
| Barcode (UPC) | 8904268849697 |
| Net contents | 120 Veggie Cap(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 296427 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Halal |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Karela Capsules by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Karela, Powder | 400 mg | -- |
| Karela Fruit Extract, Powder | 500 mg | -- |
| Bitters | 18 mg | -- |
Other ingredients: Veggie Capsule, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Contents based on standard Raw Material as per Traditional Text
Being natural product, colour may vary over time as well as from batch to batch however effectiveness remains same.
Country of Origin: India
Suggested/Recommended/Usage/Directions
Directions for use: As a dietary supplement, take 2 Veggie capsules a day before meals or as directed by your health care practitioner.
Precautions
Warning: Pregnant or lactating women are advised to consume herbal products under the advice of the healthcare practitioner.
Keep out of reach of children.
Do not use if pouch is broken.
Please consult an expert before use.
Storage
Storage: Store in a cool dry place away from direct sunlight.
FDA Disclaimer Statement
This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Herbal Hills Back to Nature
Seals/Symbols
QA ICS JAS-ANZ GMP Good Manufacturing Practice Halal India HIW21081110
Formula
Halal India HIW21081110
General Statements
For Feedback or queries Please contact us at: www.herbalhillsglobal.com Email: [email protected]
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Karela Capsules by Herbal Hills label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Karela Capsules by Herbal Hills
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Karela, Powder
Interacts with282 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
Karela, Powder monograph & interactionsKarela Fruit Extract, Powder
Interacts with282 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
Karela Fruit Extract, Powder monograph & interactions- › Bitters
Other (inactive) ingredients: Veggie Capsule, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Karela Capsules by Herbal Hills Drug Interactions
HelloPharmacist Interaction Report
Karela Capsules by Herbal Hills contains bitter melon, which interacts with a number of medications.
The biggest concern is with antidiabetes drugs — bitter melon can lower blood sugar on its own, so taking it alongside diabetes medications may push your levels too low (low blood sugar/hypoglycemia). You'll want to monitor your blood glucose closely if you combine them.
Read the full breakdown — every affected drug type, severity by severity
Bitter melon may also increase levels of certain medications that rely on a cellular pump called P-glycoprotein to move through your body; this is a moderate concern with drugs in that category. Additionally, there's a case report of a patient taking pazopanib (a cancer drug) who developed severe inflammation of the pancreas (pancreatitis) after drinking bitter melon juice daily — theoretically, bitter melon might raise pazopanib levels and increase the risk of side effects.
We couldn't check the ingredient Bitters for interactions. Altogether, these interactions span 275 individual medications.
Use the medication checker below to look up your exact drugs before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Karela Capsules?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Karela Capsules interact with 282 drugs. Click any drug to see the details.
1 of the 2 ingredients in Karela Capsules interact with drugs. Each result below shows which ingredient is responsible. Karela, Powder
BetrixabanBevyxxa
How Betrixaban interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Betrixaban interactionBictegravir, Emtricitabine, Tenofovir AlafenamideBiktarvy
How Bictegravir, Emtricitabine, Tenofovir Alafenamide interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Bictegravir, Emtricitabine, Tenofovir Alafenamide interactionBoceprevirVictrelis
How Boceprevir interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Boceprevir interactionCanagliflozinInvokana
How Canagliflozin interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Karela Fruit Extract, Powder + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Karela Fruit Extract, Powder + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Karela Fruit Extract, Powder + Canagliflozin, Metformin Hydrochloride interactionCeliprololCelicard
How Celiprolol interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Celiprolol interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Karela Fruit Extract, Powder + Chlorpropamide interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Chlortetracycline interactionCimetidineCimetidine Injection, Tagamet, Tagamet HB
How Cimetidine interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Cimetidine interactionCisapridePropulsid
How Cisapride interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Cisapride interactionClobetasolClobex, Temovate
How Clobetasol interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Clobetasol interactionCobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide FumarateGenvoya
How Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interactionColchicineColchicine, Colcrys, Colsalide Improved, Gloperba, Lodoco, Mitigare
How Colchicine interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Colchicine interactionColchicine, ProbenecidColBenemid
How Colchicine, Probenecid interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Colchicine, Probenecid interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Conjugated Estrogens, Methyltestosterone interactionCortisone AcetateCortisone Tablets, Cortone
How Cortisone Acetate interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Cortisone Acetate interactionCrizotinibXalkori
How Crizotinib interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Crizotinib interactionCyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Cyclosporine interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Cyproterone Acetate, Ethinyl Estradiol interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Karela Fruit Extract, Powder + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Karela Fruit Extract, Powder + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Karela Fruit Extract, Powder + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Karela Fruit Extract, Powder + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDarolutamideNubeqa
How Darolutamide interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Darolutamide interactionDarunavir, Cobicistat, Emtricitabine, Tenofovir AlafenamideSymtuza
How Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interactionDarunavir, RitonavirDarunavir, Ritonavir
How Darunavir, Ritonavir interacts with Karela Capsules — through 1 ingredient. Tap an ingredient for the detail:
Karela Fruit Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Karela Fruit Extract, Powder + Darunavir, Ritonavir interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Karela Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Karela, Powder
Antidiabetes Drugs
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
P-Glycoprotein Substrates
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.
Pazopanib (Votrient)
Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.
Brand information
Manufacturer and brand details for Karela Capsules, from the product label.
Karela Capsules by Herbal Hills: Common Questions
Does Karela Capsules by Herbal Hills interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this lower my blood sugar if I'm on diabetes medication?
What are the most common side effects?
Is it safe to take while pregnant?
Can I take this while breastfeeding?
Does bitter melon actually work for diabetes or blood sugar control?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Karela Capsules is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Karela Capsules’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Karela Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bitter Melon 18 references
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
- Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
- Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
- Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
- Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
- Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
- Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
- Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
- Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
- Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
- Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
- Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
- Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
- Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
- Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
- Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
- Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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