Knotgrass Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Knotgrass against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Knotgrass is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for source of resveratrol, heart and circulation support, lyme disease support (traditional/herbalist use).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Knotgrass by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Knotgrass Herb Extract in dry form. Knotgrass is a plant extract used traditionally for oral health support, particularly for gum health.
The liquid also includes alcohol, water, and glycerin as inactive ingredients to deliver the extract.
Does it work?
Couldn't assess
The evidence for knotgrass in supporting gum health (gingivitis) is rated insufficient in our data — there isn't enough reliable evidence to say whether it works for that purpose. If you're looking at this for oral health, talk with your dentist or pharmacist about whether it fits your situation.
How safe is it?
Some data gaps
Knotgrass may be reasonably tolerated for short-term use, but human safety data are limited and it can cause digestive side effects in some people. The safety information available isn't comprehensive enough to recommend it during pregnancy — some of the plant's compounds may affect the uterus.
For the same reason, avoid it while breastfeeding. If you're pregnant, nursing, or have a sensitive stomach, check with your doctor or pharmacist before starting.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That doesn't mean interactions can't happen — it means we have no flagged concerns on file.
Run your exact medications through the checker below before starting, or ask your pharmacist to confirm.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.
Knotgrass is a single-ingredient herbal extract with limited safety data and no proven effectiveness for gum health in our records. If you're interested in trying it for oral support, talk with your dentist first.
Avoid it if you're pregnant or breastfeeding, and watch for digestive upset if you do use it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Knotgrass, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 6175033218792 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2025 |
| DSLD ID | 325150 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Knotgrass by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Knotgrass Herb Extract, Dry | 983 mg | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free
Expertly extracted 100% natural Premium product
Organic alcohol
No artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Polygonum aviculare
Organic alcohol
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA
General Statements
Organic raw material.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Knotgrass by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Knotgrass by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Knotgrass Herb Extract, Dry
No knowninteractions
Japanese knotweed (Polygonum cuspidatum) is an herb best known as a natural source of resveratrol and emodin, and it is used in traditional Chinese me...
Knotgrass Herb Extract, Dry monograph & interactionsOther (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Knotgrass by Herbal Terra Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Knotgrass. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Knotgrass, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
Knotgrass by Herbal Terra: Common Questions
Does Knotgrass by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I see?
Does this actually work for gum health?
How long can I safely take this?
Are there any fillers or other ingredients I should know about?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Knotgrass is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Knotgrass’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Knotgrass's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 1 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Knotweed 1 reference
- Gonzalez Begne M, Yslas N, Reyes E, et al. Clinical effect of a Mexican sanguinaria (Polygonum aviculare L.) on gingivitis. J Ethnopharmacol 2001;74:45-51..
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC