Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Konjac Root 1000 mg Ingredients & Drug Interactions

by Puritan's Pride

Konjac Root 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Konjac Root 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Konjac Root 1000 mg is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for weight loss and appetite control, constipation, high cholesterol.Based on those ingredients, 2,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Konjac. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Konjac Root 1000 mg by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Konjac Root 1000 mg by Puritan's Pride — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Konjac Root 1000 mg by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: konjac root (also known as glucomannan) at 1,000 mg per capsule. Konjac is a soluble fiber derived from the root of the konjac plant; it absorbs water and forms a thick, viscous gel in your digestive system.

The capsule also contains gelatin and magnesium stearate as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Glucomannan's overall clinical evidence instead.

Moderate

Some clinical evidence supports Glucomannan for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Constipation — rated "Possibly Effective" (Natural Medicines).
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).
  • On file: Hyperlipidemia — rated "Possibly Effective" (Natural Medicines).

The evidence for konjac suggests it may help with constipation, diabetes management, and high cholesterol (hyperlipidemia). For high blood pressure, though, there isn't enough reliable evidence to say whether it works.

Keep in mind these are "possibly effective" ratings — the data shows promise, but more research would help confirm real-world benefit.

The evidence, ingredient by ingredient Glucomannan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Konjac is generally well tolerated when you take it with plenty of water or liquid. The most common side effects are gastrointestinal — abdominal pain, bloating, constipation, diarrhea, gas, nausea, and vomiting — especially at doses over 3 grams daily.

A rare but serious risk is choking or blockage (obstruction) of your esophagus or intestines, particularly if the powder or tablet is swallowed dry or without enough fluid. Not enough data exists to say it's safe in pregnancy — talk to your doctor before using it if you're pregnant.

Little is known about safety while breastfeeding, so caution is advised and a conversation with your pharmacist or doctor is worthwhile.

Side effects, ingredient by ingredient Glucomannan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glucomannan.
  • The most serious interaction on file is rated Moderate.
  • For scale: 2,023 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any oral medications you're on — konjac can slow their absorption and reduce how well they work. This is especially important for diabetes drugs, but applies to any medication you take by mouth.

Make sure you take konjac with at least one full glass of water or liquid to minimize the risk of choking or blockage.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Konjac is a soluble fiber that may help constipation, blood sugar, and cholesterol. The catch: it can reduce how your body absorbs other oral medications — a Moderate interaction concern.

If you take any prescription drugs by mouth, check them here before you start, and always drink plenty of water with each dose to avoid choking.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Konjac Root 1000 mg, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 025077361205
Net contents 100 Rapid Release Capsule(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 286180
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Konjac Root 1000 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
025077361205
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Konjac2000 mg--

Other ingredients: Gelatin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Puritan's Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

To reorder item # 36120 www.puritan.com 1-800-645-1030

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Note: Fiber products can affect the absorption of many medications. Do not take this product within 2 hours of taking medications or follow the advice of your health care provider.

Taking this product without enough liquid may cause choking. Do not take immediately before going to bed.

Storage

Store at room temperature.

Brand IP Statement(s)

Copyright 2019 Puritan's Pride, Inc.

Seals/Symbols

QA Quality Assured

Formula

Konjac Root 1000 mg Standardized to 90% glucomannan

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) capsules with at least 8 ounces of water or other fluid, 30-60 minutes before each meal. Taking this product without enough liquid may cause choking. Do not take immediately before going to bed.

Formulation

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish. Sodium free.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Konjac Root 1000 mg by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Konjac Root 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Konjac Root 1000 mg by Puritan's Pride

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Konjac

Interacts with
2,022 drugs
2000 mg per serving Form: Glucomannan

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and mo...

Konjac monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Konjac Root 1000 mg by Puritan's Pride Drug Interactions

Want to check YOUR meds against Konjac Root 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,022Drugs
2,022 Moderate

Ingredients driving the most interactions

Konjac 2,022

Individual Drug Interactions

The ingredients in Konjac Root 1000 mg interact with 2,022 drugs. Click any drug to see the details.

1 of the 1 ingredient in Konjac Root 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Konjac

Each ingredient & the kinds of drugs it affects

For each ingredient in Konjac Root 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Konjac1 drug type · 2,022 drugs

Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Likelihood Probable Evidence B
Konjac full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Konjac Root 1000 mg, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Konjac Root 1000 mg by Puritan's Pride: Common Questions

Does Konjac Root 1000 mg by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Konjac Root 1000 mg has a known interaction with 2,022 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Konjac Root 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will konjac interfere with my prescription medications?
Yes, possibly. Konjac can reduce how much of an oral medication your body absorbs, which might make it less effective. The risk is Moderate and applies broadly to drugs taken by mouth. Check your specific medications with the tool on this page before starting.
What are the most common side effects?
Gastrointestinal upset — abdominal pain, bloating, gas, diarrhea, constipation, nausea, and vomiting — especially if you take more than 3 grams daily or don't drink enough water with it. Rare but serious: choking or intestinal blockage if swallowed dry.
Can I take this while pregnant?
There isn't enough safety data to say. Talk to your doctor or pharmacist before using it during pregnancy so they can weigh the pros and cons for your situation.
Is konjac safe while breastfeeding?
Little is known about its safety in breastfeeding. Caution is advised, and it's worth discussing with your doctor or pharmacist before you take it.
What does konjac actually do?
It's a soluble fiber that absorbs water and becomes thick and gel-like in your digestive system. Evidence suggests it may help with constipation, blood sugar control, and high cholesterol — though the data on blood pressure isn't clear yet.
How much water should I drink with this?
Take it with at least one full glass of water or other liquid. Drinking plenty prevents choking and blockage, which are rare but serious risks if you swallow konjac dry.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Konjac Root 1000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Konjac Root 1000 mg label
Go deeper

The Full Monographs Behind Konjac Root 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glucomannan

Interacts with 2,022 drugs

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...

Read the full Glucomannan monograph →
Sources

Sources & How We Checked

Konjac Root 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glucomannan 15 references
  1. Henry DA, Mitchell AS, Aylward J, et al. Glucomannan and risk of oesophageal obstruction. Br Med J 1986;292:591-2. PubMed
  2. Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3. PubMed
  3. Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. PubMed
  4. Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
  5. Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
  6. Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. PubMed
  7. Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. PubMed
  8. Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100.
  9. Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
  10. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
  11. Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
  12. Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.
  13. Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-
  14. Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864.
  15. Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed

See these in context on the Glucomannan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team