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Dietary supplement

Konjac Root Glucomannan 2000 mg Ingredients & Drug Interactions

by Best Naturals

Konjac Root Glucomannan 2000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Konjac Root Glucomannan 2000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Konjac Root Glucomannan 2000 mg is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for weight loss and appetite control, constipation, high cholesterol.Based on those ingredients, 2,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Konjac. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Konjac Root Glucomannan 2000 mg by Best Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Konjac Root Glucomannan 2000 mg by Best Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Konjac Root Glucomannan 2000 mg by Best Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: konjac, a root fiber also called glucomannan. It's a soluble dietary fiber that absorbs water and swells in your digestive tract, which is why it's used to help with constipation and to support blood sugar and cholesterol levels.

The product also includes inactive ingredients — capsule material, silicon dioxide, magnesium stearate, and microcrystalline cellulose — that help hold the supplement together and make it easy to swallow.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: dietary fiber for digestive and weight management.
  • We looked for evidence on: Constipation, Obesity, Hyperlipidemia, Diabetes, Metabolic syndrome, appetite control — and 1 related terms.
  • The strongest evidence on file: Glucomannan is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Glucomannan is rated "Possibly Effective" for Diabetes, Hyperlipidemia.
  • Also on file: Glucomannan is rated "Insufficient Reliable Evidence To Rate" for Obesity, Metabolic syndrome.

Konjac glucomannan is possibly effective for constipation, type 2 diabetes, and high cholesterol (hyperlipidemia). The evidence supporting these uses exists but is not yet as strong as we'd like, so results can vary from person to person.

For high blood pressure, we don't hold enough reliable evidence to say whether it works.

The evidence, ingredient by ingredient Glucomannan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glucomannan is generally well tolerated when you take it with plenty of water or other liquid. The most common side effects are mild digestive complaints — abdominal pain, bloating, constipation, diarrhea, gas, nausea, or vomiting — especially if you take more than 3 grams daily.

Rare but serious concern: choking or blockage in your esophagus or intestines can happen if you swallow the capsule as a dry powder or without enough fluid. Always take it with a full glass of water.

There isn't enough data to know if it's safe in pregnancy or while breastfeeding, so talk with your doctor or pharmacist before using it in either case.

Side effects, ingredient by ingredient Glucomannan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glucomannan.
  • The most serious interaction on file is rated Moderate.
  • For scale: 2,023 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Glucomannan may decrease absorption of any oral medications (pills or capsules) taken by mouth. The biggest documented concern is with diabetes drugs like glyburide, but because it works through bulk and viscosity in your digestive tract, it could theoretically affect many different medications.

Check your specific drugs with the search tool on this page before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Konjac glucomannan is a straightforward fiber supplement that may help with constipation, blood sugar, or cholesterol — but take it with plenty of water to avoid blockage. The main thing to watch for is that it can reduce how well your body absorbs other oral medications.

Check your exact medications with the tool on this page before you start, and talk with us if you're pregnant, nursing, or unsure about timing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Konjac Root Glucomannan 2000 mg, straight from the product label.

Brand Best Naturals
Barcode (UPC) 817716012582
Net contents 180 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269755
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Konjac Root Glucomannan 2000 mg by Best Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Vegetarian Capsule(s)
Maximum serving Sizes:
3 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
817716012582
IngredientAmount% DV
Konjac2000 mg--

Other ingredients: Capsule, Silicon Dioxide, Magnesium Stearate, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Glucomannan is a calorie free dietary fiber source obtained from the root of the konjac plant. Glucomannan is a water-soluble polysaccharide with hygroscopic properties and is considered a dietary fiber. Certain research publications indicate that it may help support the following: Supports appetite control and healthy weight management. Supports healthy cholesterol levels. Supports digestive health. Supports healthy blood sugar levels.

Glucomannan 2000 mg per serving

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take three (3) capsules daily with at least 8 oz of water 30-45 minutes before a meal, or as directed by your qualified healthcare professional.

Precautions

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Caution: For adults, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Without drinking enough liquid the product may swell in the throat, causing blockage or choking. Avoid use if you ever had esophageal narrowing or swallowing difficulties. Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Keep in cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

GMP Good Manufacturing Practice Product

Formulation

Premium formula

3rd party lab tested

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Konjac Root Glucomannan 2000 mg by Best Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Konjac Root Glucomannan 2000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Konjac Root Glucomannan 2000 mg by Best Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Konjac

Interacts with
2,022 drugs
2000 mg per serving Form: Glucomannan

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and mo...

Konjac monograph & interactions

Other (inactive) ingredients: Capsule, Silicon Dioxide, Magnesium Stearate, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Konjac Root Glucomannan 2000 mg by Best Naturals Drug Interactions

Want to check YOUR meds against Konjac Root Glucomannan 2000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,022Drugs
2,022 Moderate

Ingredients driving the most interactions

Konjac 2,022

Individual Drug Interactions

The ingredients in Konjac Root Glucomannan 2000 mg interact with 2,022 drugs. Click any drug to see the details.

1 of the 1 ingredient in Konjac Root Glucomannan 2000 mg interact with drugs. Each result below shows which ingredient is responsible. Konjac

Each ingredient & the kinds of drugs it affects

For each ingredient in Konjac Root Glucomannan 2000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Konjac1 drug type · 2,022 drugs

Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Likelihood Probable Evidence B
Konjac full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Konjac Root Glucomannan 2000 mg, from the product label.

Best Naturals

See all Best Naturals products
Name
Best Naturals
Street Address
PO Box 394
City
Kenilworth
State
NJ
ZipCode
07033
Phone Number
1-877-659-6004
Web Address
www.shopbestnaturals.com
Pharmacist Counseling Corner

Konjac Root Glucomannan 2000 mg by Best Naturals: Common Questions

Does Konjac Root Glucomannan 2000 mg by Best Naturals interact with any medications?
Yes. Based on its ingredients, Konjac Root Glucomannan 2000 mg has a known interaction with 2,022 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Konjac Root Glucomannan 2000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
How much water should I drink when I take this?
You need to take it with a full glass of water or other liquid. Glucomannan swells as it absorbs water, so without enough liquid it can cause choking or blockage in your throat or intestines. Make it part of your routine: fill a glass first, then take your capsule.
What side effects might I experience?
Most people get mild digestive side effects — bloating, gas, belly pain, diarrhea, or constipation — especially when you first start or if you take more than 3 grams a day. These usually settle down as your body adjusts. Serious effects like choking or blockage are rare but happen when people don't drink enough water with it.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough reliable safety data for either pregnancy or breastfeeding. Talk with your doctor or pharmacist before using it in either case — they can help you decide what's right for you.
When should I take this relative to my other medications?
Glucomannan may slow or reduce how your body absorbs oral medications, so spacing matters. The safest approach is to talk with your pharmacist about timing — they can help you figure out how long to wait between this supplement and your other pills or capsules.
Does this really work for diabetes or high cholesterol?
The evidence says it's possibly effective for both, meaning it may help some people, but the proof isn't as strong as we'd like yet. Results vary. For high blood pressure, we don't have enough reliable data to know whether it works.
What happens if I take it without enough water?
Glucomannan can swell and block your esophagus or intestines, which is serious. This is rare but has happened, especially with dry powder or when people don't drink enough liquid. Always use a full glass of water and don't skip that step.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Konjac Root Glucomannan 2000 mg label
Go deeper

The Full Monographs Behind Konjac Root Glucomannan 2000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glucomannan

Interacts with 2,022 drugs

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...

Read the full Glucomannan monograph →
Sources

Sources & How We Checked

Konjac Root Glucomannan 2000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glucomannan 15 references
  1. Henry DA, Mitchell AS, Aylward J, et al. Glucomannan and risk of oesophageal obstruction. Br Med J 1986;292:591-2. PubMed
  2. Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3. PubMed
  3. Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. PubMed
  4. Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
  5. Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
  6. Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. PubMed
  7. Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. PubMed
  8. Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100.
  9. Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
  10. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
  11. Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
  12. Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.
  13. Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-
  14. Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864.
  15. Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed

See these in context on the Glucomannan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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