Konjac Root Glucomannan 2000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Konjac Root Glucomannan 2000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Konjac Root Glucomannan 2000 mg is a dietary supplement by Nova Nutritions with 2 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,025 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Konjac. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Konjac Root Glucomannan 2000 mg by Nova Nutritions
Ask about any prescription or over-the-counter medication and we check it for interactions with Konjac Root Glucomannan 2000 mg by Nova Nutritions — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Konjac Root Glucomannan 2000 mg by Nova Nutritions
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This powder contains one active ingredient: glucomannan, a soluble fiber derived from konjac root. Each serving delivers 2,000 mg of glucomannan, which acts as a bulking agent in your digestive system.
There are no other inactive ingredients listed.
Does it work?
Strong evidence
Glucomannan is possibly effective for constipation, diabetes, and high cholesterol (hyperlipidemia). The evidence base shows promise for these uses, though it's not definitive.
For high blood pressure, we don't have enough reliable evidence to rate whether it works. Talk to your doctor about whether this supplement fits your specific health goal.
How safe is it?
Well-documented data
Glucomannan is generally well tolerated when you take it with plenty of water or liquid. The most common side effects are mild digestive complaints — abdominal pain, bloating, constipation, diarrhea, gas, nausea, or vomiting — especially if you take more than 3 grams daily.
Rarely, it can cause choking or blockage in your esophagus or intestines, particularly if you swallow it as a dry powder or tablet without enough fluid. During pregnancy, there isn't enough reliable safety data, so talk to your doctor before using it.
Similarly, there's little information on safety while breastfeeding — caution is advised, and your doctor or pharmacist can help you weigh the pros and cons.
Meds to double-check
Moderate interaction found
Check any oral medications you take — glucomannan may reduce how your body absorbs them (moderate severity). Spacing your doses 2 hours apart can help.
Use the medication checker below to verify your exact drugs before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Glucomannan may help with constipation, blood sugar control, or cholesterol if the evidence holds for your situation. The main concern is that it can interfere with how your body absorbs other oral medications, so separate doses by at least 2 hours and always take it with plenty of water to prevent blockage.
Check your medications with the tool on this page, and talk to your pharmacist before starting — especially if you're pregnant, breastfeeding, or take diabetes or cholesterol drugs.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Konjac Root Glucomannan 2000 mg, straight from the product label.
| Brand | Nova Nutritions |
|---|---|
| Barcode (UPC) | 732363271116 |
| Net contents | 8 Ounce(s); 227 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2020 |
| DSLD ID | 229313 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Konjac Root Glucomannan 2000 mg by Nova Nutritions, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Dietary Fiber | 2 Gram(s) | 7% |
| Konjac | 2 Gram(s) | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Konjac Glucomannan is a water-soluble polysaccharide with hygyroscopic properties and is considered a dietary fiber. The dry powder swells into bulky fiber in water, absorbing up to 50 times its weight while in water. Glucomannan’s principal use is as a bulking agent to promote the feeling of fullness or satiety, thereby helping to manager food intake. Glucomannan might work in the stomach and intestines by absorbing water to form a bulky fiber which treats constipation.
Konjac Root Glucomannan 2000 mg / serving
Precautions
Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of the reach of children.
Do not use if safety seal is broken or missing.
Storage
Keep in cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Supports weight management & healthy cholesterol level
Free of: Artificial color, preservatives, sugar, starch, milk, corn, gluten, wheat, yeast, fish.
GMP Good Manufacturing Practice Product
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 1/2 level teaspoon (2g) one to two times daily with at least 8 oz of water 30-45 minutes before a meal, or as directed by your qualified healthcare professional.
Seals/Symbols
GMP Good Manufacturing Practice Product Made in USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Konjac Root Glucomannan 2000 mg by Nova Nutritions label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Konjac Root Glucomannan 2000 mg by Nova Nutritions
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Gram(s) Dosage formPowder Servings per container57 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsKonjac
Interacts with2,022 drugs
Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and mo...
Konjac monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Konjac Root Glucomannan 2000 mg by Nova Nutritions Drug Interactions
HelloPharmacist Interaction Report
Nova Nutritions' Konjac Root Glucomannan 2000 mg can interact with oral medications.
Glucomannan is a viscous fiber that bulks up in your digestive tract, and there's concern it may slow or reduce how your body absorbs drugs taken by mouth. A small study showed that glucomannan alongside glyburide (a diabetes medication) lowered blood levels of the drug — a moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Because of how glucomannan works in your gut, it could theoretically affect absorption of many oral medications. The interaction risk is moderate across oral drugs generally.
Altogether, these interactions span 2,003 individual medications.
To be safe, take any oral medication at least 2 hours apart from this supplement — ideally, ask your pharmacist or doctor about the timing that works best for your specific drugs. Use the medication checker on this page to look up your exact medications before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Konjac Root Glucomannan 2000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Konjac Root Glucomannan 2000 mg interact with 2,025 drugs. Click any drug to see the details.
2 of the 2 ingredients in Konjac Root Glucomannan 2000 mg interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Konjac
Acetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Diphenhydramine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
How Acetaminophen, Doxylamine, Pseudoephedrine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Doxylamine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Doxylamine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Hydrocodone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Ibuprofen interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Meperidine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Meperidine interactionAcetaminophen, MethocarbamolRobaxacet
How Acetaminophen, Methocarbamol interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Methocarbamol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Methocarbamol interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Orphenadrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Orphenadrine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Oxycodone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Oxycodone interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Pamabrom, Pyrilamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Pentazocine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Pentazocine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Phenylephrine, Chlorpheniramine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetaminophen, PhenylpropanolamineTetra Caps
How Acetaminophen, Phenylpropanolamine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Phenylpropanolamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Phenylpropanolamine interactionAcetaminophen, Phenylpropanolamine, PhenyltoloxamineSinubid
How Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, PhenyltoloxaminePercogesic, Relagesic
How Acetaminophen, Phenyltoloxamine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Phenyltoloxamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Phenyltoloxamine interactionAcetaminophen, Phenyltoloxamine, SalicylamideLobac
How Acetaminophen, Phenyltoloxamine, Salicylamide interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Phenyltoloxamine, Salicylamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Phenyltoloxamine, Salicylamide interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Propoxyphene interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Propoxyphene interactionAcetaminophen, PseudoephedrineChildren's Tylenol Sinus, Dristan N.D., Non-Aspirin Sinus, Ornex, Ornex-Max, Sinutab +5 more
How Acetaminophen, Pseudoephedrine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Pseudoephedrine interactionAcetaminophen, Pseudoephedrine, TriprolidineActifed Plus ES
How Acetaminophen, Pseudoephedrine, Triprolidine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetaminophen, Pseudoephedrine, Triprolidine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Pseudoephedrine, Triprolidine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetazolamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetohexamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetohexamide interactionAcetohydroxamic AcidLithostat
How Acetohydroxamic Acid interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetohydroxamic Acid interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetohydroxamic Acid interactionAcetophenazineTindal
How Acetophenazine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetophenazine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetophenazine interactionAcetylcholineMiochol-E
How Acetylcholine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetylcholine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetylcholine interactionAcetylcysteine (prescription Drug)Cetylev, Legubeti
How Acetylcysteine (prescription Drug) interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetylcysteine (prescription Drug) interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetylcysteine (prescription Drug) interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acetylsalicylic Acid interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetylsalicylic Acid interactionAcitretinSoriatane
How Acitretin interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acitretin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acitretin interactionAcrivastine, PseudoephedrineSemprex D
How Acrivastine, Pseudoephedrine interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acrivastine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acrivastine, Pseudoephedrine interactionAcyclovirAvaclyr, Sitavig, Zovirax, Zovirax Injection
How Acyclovir interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Acyclovir interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acyclovir interactionAdagrasibKrazati
How Adagrasib interacts with Konjac Root Glucomannan 2000 mg — through 2 ingredients. Tap an ingredient for the detail:
KonjacOral Drugs Moderate
Interaction Summary
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Konjac + Adagrasib interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Adagrasib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Konjac Root Glucomannan 2000 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Konjac
Oral Drugs
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.
Brand information
Manufacturer and brand details for Konjac Root Glucomannan 2000 mg, from the product label.
Nova Nutritions
See all Nova Nutritions products- Name
- Nova Nutritions
- City
- Scotch Plains
- State
- New Jersey
- ZipCode
- 07076
- Web Address
- www.novanutritions.com
Konjac Root Glucomannan 2000 mg by Nova Nutritions: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Konjac Root Glucomannan 2000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographGlucomannan
Interacts with 2,022 drugsGlucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...
Read the full Glucomannan monograph →Sources & How We Checked
Konjac Root Glucomannan 2000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Glucomannan 15 references
- Henry DA, Mitchell AS, Aylward J, et al. Glucomannan and risk of oesophageal obstruction. Br Med J 1986;292:591-2. PubMed
- Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3. PubMed
- Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. PubMed
- Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
- Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
- Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. PubMed
- Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. PubMed
- Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100.
- Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
- Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
- Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
- Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.
- Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-
- Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864.
- Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC