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Dietary supplement

Nattokinase 100 mg 2000 FU Ingredients & Drug Interactions

by Nova Nutritions

Nattokinase 100 mg 2000 FU label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nattokinase 100 mg 2000 FU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nattokinase 100 mg 2000 FU is a dietary supplement by Nova Nutritions with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nattokinase 100 mg 2000 FU by Nova Nutritions

Ask about any prescription or over-the-counter medication and we check it for interactions with Nattokinase 100 mg 2000 FU by Nova Nutritions — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nattokinase 100 mg 2000 FU by Nova Nutritions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: nattokinase 100 mg per capsule at a potency of 2000 fibrinolytic units (FU). Nattokinase is an enzyme derived from natto, a traditional Japanese fermented soybean food, and is thought to work through blood-thinning and clot-dissolving effects.

The capsule also contains inactive ingredients — cellulose, silica, and vegetable stearate — which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: maintain normal circulatory health.
  • We looked for evidence on: Cardiovascular disease (CVD), Hypertension, Hyperlipidemia, Atherosclerosis, Peripheral arterial disease (PAD), Venous insufficiency — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence we hold for nattokinase does not yet establish its effectiveness for the conditions studied: angina, atherosclerosis, cancer, cardiovascular disease, and chronic fatigue syndrome all carry a rating of insufficient reliable evidence. That means the research so far hasn't been strong or complete enough to make a confident claim either way.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally tolerated in the short term, but its blood-thinning properties mean you should be cautious if you have any bleeding risk. Rare reports of bleeding, including a serious case of brain hemorrhage, have been linked to nattokinase use.

Additionally, it can trigger hypersensitivity reactions — including anaphylaxis in rare cases — in people sensitive to natto or its compounds, with symptoms appearing within 2 hours of taking it. The safety data advises against nattokinase during pregnancy because there isn't enough information to know it's safe.

The same holds for breastfeeding — safety is unknown, so it's best avoided until more is known.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on any blood thinners or antiplatelet drugs (like warfarin, apixaban, dabigatran, rivaroxaban, clopidogrel, or aspirin) — nattokinase raises your bleeding risk. Also flag any blood pressure medications you're taking, since nattokinase may lower your pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nattokinase may appeal to those interested in blood flow and cardiovascular support, but the evidence for specific conditions isn't yet solid enough to rate. The real concern is if you take blood thinners, aspirin, or blood pressure medications — this supplement can strengthen those effects and raise your bleeding or low-pressure risk.

Talk with your doctor or pharmacist before starting it, especially if you're pregnant, breastfeeding, or have any bleeding tendency.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nattokinase 100 mg 2000 FU, straight from the product label.

Brand Nova Nutritions
Barcode (UPC) 732363270126
Net contents 180 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 229278
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nattokinase 100 mg 2000 FU by Nova Nutritions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
180
UPC/BARCODE
732363270126
IngredientAmount% DV
Nattokinase100 mg--

Other ingredients: Cellulose, Silica, Cellulose, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Nattokinase is a systemic enzyme isolated from the traditional Japanese soy food, natto. The enzyme is composed of 275 amino acide and is considered to be one of the most active functional ingredients found is natto.

Suggested/Recommended/Usage/Directions

Nattokinase is to be used as part of your diet and exercise program to maintain normal circulatory healthy.

Suggested Use: As a dietary supplement, take one (1) Vcap one to two times daily on an empty stomach. Consider taking this product in combination with Best Naturals CoQ10, Vitamin E and Fish or Flax Seed Oil.

Precautions

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Storage

Keep in cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Promotes healthy circulatory health & cardiovascular function

Free of: Artificial color, preservatives, sugar, starch, milk, corn, gluten, wheat, yeast, fish.

GMP Good Manufacturing Practice Product

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice Product Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nattokinase 100 mg 2000 FU by Nova Nutritions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nattokinase 100 mg 2000 FU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nattokinase 100 mg 2000 FU by Nova Nutritions

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Nattokinase

Interacts with
289 drugs
100 mg per serving

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Cellulose, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nattokinase 100 mg 2000 FU by Nova Nutritions Drug Interactions

Want to check YOUR meds against Nattokinase 100 mg 2000 FU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Nattokinase 100 mg 2000 FU interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nattokinase 100 mg 2000 FU interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Nattokinase 100 mg 2000 FU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nattokinase 100 mg 2000 FU, from the product label.

Nova Nutritions

See all Nova Nutritions products
Name
Nova Nutritions
City
Scotch Plains
State
New Jersey
ZipCode
07076
Web Address
www.novanutritions.com
Pharmacist Counseling Corner

Nattokinase 100 mg 2000 FU by Nova Nutritions: Common Questions

Does Nattokinase 100 mg 2000 FU by Nova Nutritions interact with any medications?
Yes. Based on its ingredients, Nattokinase 100 mg 2000 FU has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nattokinase 100 mg 2000 FU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is nattokinase safe if I'm pregnant or breastfeeding?
No, the safety data advises against it in pregnancy because there isn't enough information. For breastfeeding, safety is unknown, so it's best avoided. Talk with your doctor or pharmacist for personalized advice.
Can I take this if I have a bleeding disorder or take aspirin?
You should check with your doctor first. Nattokinase has blood-thinning effects, and there's a documented case of serious brain bleeding when someone combined it with aspirin. Your provider needs to know about both before you add this supplement.
What are the side effects?
It's generally well tolerated short-term, but bleeding — including rare serious brain bleeding — has been reported. If you're sensitive to fermented soybeans (natto), you could have an allergic reaction within 2 hours, ranging from throat swelling to anaphylaxis.
Does it actually work for heart disease or high blood pressure?
The evidence we hold doesn't yet establish that — conditions like cardiovascular disease and angina all carry a rating of insufficient reliable evidence. Some research does suggest it may lower blood pressure, but the overall case isn't settled.
What is FU, and what does 2000 FU mean?
FU stands for fibrinolytic units, a measure of nattokinase's clot-dissolving potency. This product provides 2000 FU per capsule.
Does it contain any allergens?
Yes — nattokinase is derived from fermented soybeans (natto). If you're sensitive to natto, soy, or the enzyme itself, you could have an allergic reaction. Check the label and talk with your pharmacist if you have soy allergies.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nattokinase 100 mg 2000 FU label
Go deeper

The Full Monographs Behind Nattokinase 100 mg 2000 FU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Nattokinase 100 mg 2000 FU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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