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Dietary supplement

Kudzu 20:1 Concentrated Extract Ingredients & Drug Interactions

by Samsara Herbs

Kudzu 20:1 Concentrated Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kudzu 20:1 Concentrated Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kudzu 20:1 Concentrated Extract is a dietary supplement by Samsara Herbs with 1 active ingredient. Its ingredients are commonly taken for alcohol cravings and reduction, menopausal symptoms, heart and blood vessel health.Based on those ingredients, 584 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Kudzu. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Kudzu 20:1 Concentrated Extract by Samsara Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Kudzu 20:1 Concentrated Extract by Samsara Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Kudzu 20:1 Concentrated Extract by Samsara Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: kudzu, a legume root concentrated into a 20:1 extract — that means the powder is 20 times more potent than the raw root. There are no other inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Kudzu's overall clinical evidence instead.

Moderate

Some clinical evidence supports Kudzu for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Alcohol use disorder — rated "Possibly Effective" (Natural Medicines).

The data we hold shows kudzu is possibly effective for alcohol use disorder. For hay fever (allergic rhinitis), angina, and back pain, there isn't enough reliable evidence yet to establish whether it works.

If you're considering it for one of those other uses, the science just isn't settled.

The evidence, ingredient by ingredient Kudzu

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Kudzu is generally well tolerated in short-term studies, though long-term safety data doesn't exist yet. The main side effects reported in trials — nausea, indigestion, bloating, dizziness, and a skin rash — occurred at rates no higher than placebo.

One case report described an allergic reaction with a rash spreading across the body, but that was from a combination herbal product, not kudzu alone. During pregnancy, there isn't enough safety data and there's concern about hormone-like effects, so avoid it.

The same goes for breastfeeding — there's too little information to recommend it.

Side effects, ingredient by ingredient Kudzu

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Kudzu.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 585 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with us if you're on drugs that damage the liver, blood thinners or antiplatelet agents, estrogen or tamoxifen, methotrexate, diabetes medications, or products with caffeine. These are the medication types where kudzu has documented interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Kudzu is worth considering if you're working on alcohol use disorder and want to explore what the evidence supports. If you're on blood thinners, hormone therapy, diabetes medication, or anything that affects your liver, check with your pharmacist first — the interactions here are real enough to warrant that conversation.

Long-term safety data is thin, so keep that in mind.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kudzu 20:1 Concentrated Extract, straight from the product label.

Brand Samsara Herbs
Barcode (UPC) X0013L75XB
Net contents 8 Ounce(s); 227 Gram(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 319966
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kudzu 20:1 Concentrated Extract by Samsara Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2505 mg
Maximum serving Sizes:
2505 mg
Servings per container
90
UPC/BARCODE
X0013L75XB
IngredientAmount% DV
Kudzu2505 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Full Spectrum

Full Spectrum herbal extracts are made by concentrating the herb into an extract form, while maintaining all of its original compounds. The ideal choice for those wanting a more potent version of a complete herbal powder.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice USA tested 3rd party USA tested

General Statements

About Us At Samsara Herbs, we believe that all positive change in the world must first begin with positive change from within. We invite you to tap into your own infinite power through the use of our potent herbal extracts! We seek out only quality herbs from our trusted sources from around the world for use in our herbal extracts. Samsara Herbs, dedicated to empowering your life force!

Formula

Description Kudzu root, also called Japanese arrowroot, is native to China, Japan, and Korea. Kudzu is an extremely fast-growing vine and it has a long history of use in TCM. Our water soluble herbal extracts are best mixed in juice or a smoothie, although mixing in water is perfectly fine if you can tolerate the taste.

Suggested/Recommended/Usage/Directions

Our water soluble herbal extracts are best mixed in juice or a smoothie, although mixing in water is perfectly fine if you can tolerate the taste.

Suggested Use: Take 1 scoop 1-3 times per day or as recommended by your health care professional.

Storage

Storage Cool dry place, out of direct sunlight.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: If you have a medical condition, are pregnant or taking medications, consult your health care professional before using this product.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kudzu 20:1 Concentrated Extract by Samsara Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kudzu 20:1 Concentrated Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kudzu 20:1 Concentrated Extract by Samsara Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2505 mg Dosage formPowder Servings per container90 Amounts shown are per serving.

Kudzu

Interacts with
584 drugs
2505 mg per serving

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Earl...

Kudzu monograph & interactions
Interaction report

Kudzu 20:1 Concentrated Extract by Samsara Herbs Drug Interactions

Want to check YOUR meds against Kudzu 20:1 Concentrated Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
584Drugs
512 Moderate 72 Minor

Ingredients driving the most interactions

Kudzu 584

Individual Drug Interactions

The ingredients in Kudzu 20:1 Concentrated Extract interact with 584 drugs. Click any drug to see the details.

1 of the 1 ingredient in Kudzu 20:1 Concentrated Extract interact with drugs. Each result below shows which ingredient is responsible. Kudzu

Each ingredient & the kinds of drugs it affects

For each ingredient in Kudzu 20:1 Concentrated Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Kudzu7 drug types · 584 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Kudzu isoflavones are reported to have antiplatelet activity.

Likelihood Possible Evidence D
Caffeine

Theoretically, taking kudzu with caffeine might increase levels of caffeine.
In healthy males injected with the kudzu constituent puerarin, caffeine clearance and metabolism is inhibited. This effect has been attributed to inhibition of cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if taking kudzu orally would have this same effect.

Likelihood Probable Evidence D
Estrogens

Theoretically, kudzu might alter the effects of estrogen therapy.
Some research suggests that kudzu has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
There is some concern that kudzu can adversely affect the liver.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, taking kudzu with methotrexate might increase the risk of methotrexate toxicity.
Preclinical research suggests that kudzu extract greatly reduces the elimination and increases the toxicity of methotrexate. Kudzu might inhibit organic anion transporters (OATs) that are responsible for hepatobiliary and renal excretion of anions, similar to the interaction between methotrexate and non-steroidal anti-inflammatory drugs (NSAIDs).

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, kudzu might interfere with tamoxifen activity.
Some research suggests that kudzu may have estrogenic effects.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Kudzu might lower blood glucose levels and have additive effects in patients treated with antidiabetic agents. The dose of diabetes medications might need to be adjusted.

Likelihood Unlikely Evidence D
Kudzu full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kudzu 20:1 Concentrated Extract, from the product label.

Samsara Herbs

See all Samsara Herbs products
Name
Samsara Herbs Inc.
Street Address
PO Box 160215
City
Clearfield
State
Utah
ZipCode
84016
Phone Number
1-844-972-6727
Web Address
www.SamsaraHerbs.com
Pharmacist Counseling Corner

Kudzu 20:1 Concentrated Extract by Samsara Herbs: Common Questions

Does Kudzu 20:1 Concentrated Extract by Samsara Herbs interact with any medications?
Yes. Based on its ingredients, Kudzu 20:1 Concentrated Extract has a known interaction with 584 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kudzu 20:1 Concentrated Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is kudzu safe to take while pregnant or breastfeeding?
No. During pregnancy, there isn't enough safety data and kudzu has hormone-like effects, so it's best avoided. For breastfeeding, there's too little information to recommend it. Talk with your doctor or pharmacist about what's right for your situation.
What side effects might I notice?
Nausea, indigestion, bloating, or dizziness are the ones reported in trials, but they didn't show up more often than placebo. A skin rash is rare. If you notice anything unusual, let us know.
Does kudzu actually help with alcohol use disorder?
The evidence says kudzu is possibly effective for it, which means there's some promise but it's not a slam dunk. It's worth discussing with your doctor as part of a broader plan.
Can I take kudzu long-term?
Short-term safety looks okay, but we don't have solid data on long-term use. If you're thinking about taking it for months on end, that's a good reason to check in with your pharmacist first.
Will this interfere with my birth control?
Kudzu has hormone-like effects and might alter how estrogen therapy works, so there's a real possibility it could affect birth control. Run it past your pharmacist or doctor before you add it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Kudzu 20:1 Concentrated Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kudzu 20:1 Concentrated Extract label
Go deeper

The Full Monographs Behind Kudzu 20:1 Concentrated Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Kudzu

Interacts with 584 drugs

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Early research is promising for cutting back...

Read the full Kudzu monograph →
Sources

Sources & How We Checked

Kudzu 20:1 Concentrated Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Kudzu 21 references
  1. Woo J, Lau E, Ho SC, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause 2003;10:352-61. PubMed
  2. Akita H, Sowa J, Makiura M, et al. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48:348-9. PubMed
  3. Luo ZR, Zheng B. [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001;21:31-3 .
  4. Lee KT, Sohn IC, Kim DH, et al. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res 2000;23:461-6.
  5. Yu Z, Zhang G, Zhao H. [Effects of Puerariae isoflavone on blood viscosity, thrombosis and platelet function]. Zhong Yao Cai 1997;20:468-9.
  6. Hsu FL, Liu IM, Kuo DH, et al. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod 2003;66:788-92. PubMed
  7. Chiang HM, Fang SH, Wen KC, et al. Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats. Toxicol Appl Pharmacol 2005;209:263-8.
  8. Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010;33(2):243-246. PubMed
  9. Hsu, H. H., Chang, C. K., Su, H. C., Liu, I. M., and Cheng, J. T. Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. Planta Med 2002;68(11):999-1003.
  10. Zheng, G., Zhang, X., Zheng, J., Meng, Q., and Zheng, D. [Estrogen-like effects of puerarin and total isoflavones from Pueraria lobata]. Zhong.Yao Cai. 2002;25(8):566-568.
  11. Qi, B. L. and Qi, B. M. [Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats]. Zhongguo Zhong.Yao Za Zhi. 2002;27(11):850-852.
  12. Akita, H., Sowa, J., Makiura, M., Akamatsu, H., and Matsunaga, K. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48(6):348-349. PubMed
  13. Manonai, J., Chittacharoen, A., Theppisai, U., and Theppisai, H. Effect of Pueraria mirifica on vaginal health. Menopause. 2007;14(5):919-924. PubMed
  14. Chandeying, V. and Sangthawan, M. Efficacy comparison of Pueraria mirifica (PM) against conjugated equine estrogen (CEE) with/without medroxyprogesterone acetate (MPA) in the treatment of climacteric symptoms in perimenopausal women: phase III study. J M
  15. Virojchaiwong, P., Suvithayasiri, V., and Itharat, A. Comparison of Pueraria mirifica 25 and 50 mg for menopausal symptoms. Arch.Gynecol.Obstet. 2011;284(2):411-419. PubMed
  16. Hou, Q., Ao, X., Li, G., and Zhang, Y. [Puerarin combined with avandia for diabetic nephropathy]. Zhong.Nan.Da.Xue Xue Bao Yi Xue Ban. 2012;37(1):73-77.
  17. Kim HJ, Kim H, Ahn JH, Suk JH. Liver injury induced by herbal extracts containing mistletoe and kudzu. J Altern Complement Med 2015;21(3):180-5. PubMed
  18. Santosh N, Mohan K, Royana S, Yamini TB. Hepatotoxicity of tubers of Indian Kudzu (Pueraria tuberosa) in rats. Food Chem Toxicol. 2010 Apr;48(4):1066-71. PubMed
  19. Teschke R, Zhang L, Long H, Schwarzenboeck A, Schmidt-Taenzer W, Genthner A, Wolff A, Frenzel C, Schulze J, Eickhoff A. Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases. Ann Hepatol. 2015 Jan-Feb;14(1):7-19. DOI
  20. Wang D, Qiu L, Wu X, Wei H, Xu F. Evaluation of kudzu root extract-induced hepatotoxicity. J Ethnopharmacol. 2015 Dec 24;176:321-6. PubMed
  21. Warinsiriruk P, Tantitham C, Cherdshewasart W, Shobeiri SA, Manonai J. Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause. Maturitas 2022;160:4-10. PubMed

See these in context on the Kudzu monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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