Kyolic Lecithin Ingredients & Drug Interactions
by Kyolic
What is this page for?
First and foremost: checking Kyolic Lecithin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Kyolic Lecithin is a dietary supplement by Kyolic with 2 active ingredients. Its ingredients are commonly taken for high cholesterol, liver health, brain and memory support.Based on those ingredients, 989 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Aged Garlic extract powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Kyolic Lecithin by Kyolic
Ask about any prescription or over-the-counter medication and we check it for interactions with Kyolic Lecithin by Kyolic — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Kyolic Lecithin by Kyolic
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Kyolic Lecithin contains two active ingredients: lecithin and aged garlic extract powder. Lecithin is a fat-like substance derived from plant or animal sources; in this product it may support cell function and membrane health.
Aged garlic extract powder is garlic that's been fermented over time, thought to retain some of garlic's traditional uses for heart and metabolic health. The product also contains inactive ingredients — gelatin (the capsule), silica, and magnesium stearate — that help with manufacturing and stability.
Does it work?
Moderate evidence
The evidence for lecithin is mixed. It's rated likely ineffective for Alzheimer disease, and the data on age-related cognitive decline, fatty liver disease (from total parenteral nutrition), anxiety, and bipolar disorder is too thin to rate either way.
Aged garlic extract has a stronger evidence base — it's possibly effective for high blood pressure, blood vessel disease (atherosclerosis), type 2 diabetes, gum disease (periodontitis), and nonalcoholic fatty liver disease. That said, 'possibly effective' means the evidence is promising but not yet strong.
How safe is it?
Well-documented data
Both ingredients are generally well tolerated when used orally. Lecithin may cause stomach upset — abdominal pain, diarrhea, bloating, and nausea — and can trigger allergic skin reactions in people with egg or soy allergies.
Garlic commonly causes body odor, bad breath, stomach pain, gas, and nausea; it rarely causes serious bleeding or allergic reactions. The product facts don't contain enough data on aged garlic extract powder safety during pregnancy and lactation to advise either way — talk with your doctor or pharmacist about your individual situation.
Lecithin is rated likely safe in pregnancy and lactation.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist if you take blood thinners or antiplatelet drugs (including warfarin), blood pressure medications, diabetes medications, drugs metabolized by your liver (especially protease inhibitors or tacrolimus), or any medication you're not sure about. The aged garlic extract can affect how these drugs work.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help with blood pressure, blood sugar, or liver health, but the evidence is still forming. If you take any blood thinners, blood pressure meds, diabetes drugs, or HIV protease inhibitors, check your exact medications with the tool on this page first.
Stomach upset and bad breath are common. Ask your pharmacist before you start, especially if you're pregnant, nursing, or have an egg or soy allergy.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Kyolic Lecithin, straight from the product label.
| Brand | Kyolic |
|---|---|
| Barcode (UPC) | 023542104432 |
| Net contents | 300 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2015 |
| DSLD ID | 42219 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Kyolic Lecithin by Kyolic, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lecithin | 380 mg | -- |
| Aged Garlic extract powder | 600 mg | -- |
Other ingredients: Gelatin, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Aged Garlic Extract(TM)
Take the best-Kyolic Aged Garlic Extract, the most scientifically researched, highest quality and best-selling odorless Sociable Garlic(R).
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Do not use if safety tear band or inner seal is broken or missing.
Lecithin derived from soybeans.
Keep out of reach of children.
Seals/Symbols
GMP Certified
FDA Statement of Identity
Odorless Organic Garlic Supplement
General Statements
CHOLESTEROL FORMULA 104
They are then aged to perfection in a unique extraction process to eliminate odor and create beneficial compounds found only in Kyolic. This combination of Lecithin and Aged Garlic Extract supports healthy cholesterol levels and overall cardiovascular health.
Suggested/Recommended/Usage/Directions
SUGGESTED USE: Take two capsules with a meal twice daily.
Formulation
FREE OF: sodium, yeast, dairy, preservatives, sugar, gluten, artificial colors or flavors.
(in compliance with the California Certified Organic Farmers).
Kyolic(R) Aged Garlic Extract(TM) begins with 100% organically grown garlic bulbs.
Odorless Organic Garlic Supplement
Storage
Store in a cool, dry place with cap tight.
General
L104A43E
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Kyolic Lecithin by Kyolic label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Kyolic Lecithin by Kyolic
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Lecithin
No knowninteractions
Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting...
Lecithin monograph & interactionsAged Garlic extract powder
Interacts with989 drugs
Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usuall...
Aged Garlic extract powder monograph & interactionsOther (inactive) ingredients: Gelatin, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Kyolic Lecithin by Kyolic Drug Interactions
HelloPharmacist Interaction Report
Kyolic Lecithin contains two active ingredients, and the aged garlic extract powder in it does interact with a number of medications.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs — garlic can increase your bleeding risk by thinning your blood further, and there's a specific report of patients whose warfarin levels shifted when they added garlic.
Read the full breakdown — every affected drug type, severity by severity
Garlic in this product may also lower your blood pressure, so if you're already on blood pressure medications (antihypertensives), it could push your numbers too low. It can interact with drugs that your liver breaks down, including some HIV medications (protease inhibitors) and the transplant drug tacrolimus — garlic may raise or lower levels of certain drugs metabolized this way.
Additionally, garlic may lower blood sugar, so if you take diabetes medications (antidiabetes drugs), you'll want to check for a combined effect.
Lecithin, the other active ingredient, shows no known interactions in our data. Altogether, these interactions span 977 individual medications.
Use the medication checker on this page to look up your specific drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Kyolic Lecithin?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Kyolic Lecithin interact with 989 drugs. Click any drug to see the details.
1 of the 2 ingredients in Kyolic Lecithin interact with drugs. Each result below shows which ingredient is responsible. Aged Garlic extract powder
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Aged Garlic Extract Powder + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Aged Garlic Extract Powder + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Aged Garlic Extract Powder + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Aged Garlic Extract Powder + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Aged Garlic Extract Powder + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Aged Garlic Extract Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Extract Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Kyolic Lecithin — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Extract PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Extract Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Kyolic Lecithin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Aged Garlic extract powder
Anticoagulant/Antiplatelet Drugs
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time.
Antidiabetes Drugs
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research suggests that garlic and garlic extract lower blood glucose levels in healthy and diabetic individuals.
Antihypertensive Drugs
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
In human research, both garlic and garlic extracts have blood pressure-lowering effects.
Atazanavir (Reyataz)
Theoretically, garlic might decrease levels and effects of atazanavir.
In a case report, a patient consuming six stir-fried garlic cloves three times weekly developed suboptimal atazanavir levels and increases in HIV viral load. While the exact cause of this interaction is unclear, there is speculation that garlic might decrease the intestinal absorption of atazanavir or increase its metabolism by inducing cytochrome P450 3A4 (CYP3A4). Until more is known, advise patients not to consume large amounts of garlic while taking atazanavir.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Some human research suggests that garlic may induce INTESTINAL CYP3A4, reducing levels of drugs metabolized by this enzyme. This is primarily based on a study showing that taking a specific allicin-containing garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induced CYP3A4 in the gut mucosa. Another study shows that giving docetaxel intravenously, bypassing the CYP3A4 enzymes in the gut mucosa, along with the same specific garlic product for 12 consecutive days, does not affect docetaxel levels. Conversely, there is concern that garlic may inhibit HEPATIC CYP3A4. In a single case report, increased tacrolimus levels and liver injury occurred in a liver transplant patient after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. Several other studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Isoniazid
Theoretically, garlic might decrease levels of isoniazid.
Animal research suggests that an aqueous extract of garlic reduces isoniazid levels by about 65%. Garlic reduced the maximum concentration (Cmax) and area under the curve (AUC), but not the half-life, of isoniazid. This suggests that garlic extract might inhibit isoniazid absorption across the intestinal mucosa; however, the exact mechanism of this potential interaction is not known.
Protease Inhibitors (Pis)
Theoretically, garlic products containing allicin might decrease levels of PIs.
Protease inhibitors are metabolized by cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4, reducing plasma levels of protease inhibitors. This is primarily based on a study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces levels of saquinavir, a PI, by approximately 50%. It is speculated that the allicin constituent induce CYP3A4 in the gut mucosa. Several studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Saquinavir (Fortovase, Invirase)
Theoretically, garlic containing allicin might decrease levels of saquinavir.
Saquinavir is a substrate of cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4 and cause subtherapeutic levels of saquinavir. This is primarily based on a pharmacokinetic study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induces CYP3A4 in the gut mucosa. Several pharmacokinetic studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin. Until more is known about this potential interaction, use garlic containing allicin cautiously in patients taking saquinavir.
Sofosbuvir (Sovaldi)
Theoretically, taking garlic with sofosbuvir might decrease its effectiveness.
Animal research in rats shows that giving aged garlic extract 120 mg/kg orally daily for 14 days decreases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 36%, increases the clearance by 63%, and decreases the plasma concentrations at 1 and 8 hours by 35% and 58%, respectively. This interaction is hypothesized to be due to induction of intestinal P-glycoprotein expression by garlic.
Tacrolimus (Prograf)
Theoretically, garlic might increase levels of tacrolimus.
In one case report, a liver transplant patient taking tacrolimus experienced increased tacrolimus levels and liver injury after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. It is speculated that garlic inhibited hepatic cytochrome P450 3A4 (CYP3A4), which increased plasma levels of tacrolimus.
Warfarin (Coumadin)
Theoretically, garlic might increase the risk of bleeding with warfarin.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time. In addition, there is a report of two patients who experienced an increase in a previously stabilized international normalized ratio (INR) with concomitant garlic and warfarin use. However, this report has been subsequently debated due to limited clinical information. Other clinical studies have not identified an effect of garlic on INR, warfarin pharmacokinetics, or bleeding risk. More evidence is needed to determine the safety of using garlic with warfarin.
Brand information
Manufacturer and brand details for Kyolic Lecithin, from the product label.
Kyolic
See all Kyolic products- Name
- Wakunaga of America Co., Ltd.
- Street Address
- 23501 Madero
- City
- Mission Viejo
- State
- CA
- ZipCode
- 92691
- Web Address
- www.kyolic.com
Kyolic Lecithin by Kyolic: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Kyolic Lecithin’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lecithin
Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting most of its health claims is limited, t...
Read the full Lecithin monograph → Herb & supplement monographGarlic
Interacts with 989 drugsGarlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usually small. It is generally safe in food am...
Read the full Garlic monograph →Sources & How We Checked
Kyolic Lecithin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 163 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lecithin 9 references
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- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
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- Gelenberg AJ, Dorer DJ, Wojcik JD, et al. A crossover study of lecithin treatment of tardive dyskinesia. J Clin Psychiatry 1990;51:149-53.
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- Palm M, Moneret-Vautrin DA, Kanny G, et al. Food allergy to egg and soy lecithins. Allergy 1999;54:1116-7. PubMed
- Drachman DA, Glosser G, Fleming P, et al. Memory decline in the aged: treatment with lecithin and physostigmine. Neurology 1982;32:944-50. PubMed
- Gelenberg, A. J., Doller-Wojcik, J. C., and Growdon, J. H. Choline and lecithin in the treatment of tardive dyskinesia: preliminary results from a pilot study. Am J Psychiatry 1979;136(6):772-776. PubMed
- Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part 184: Direct food substances affirmed as Generally Recognized as Safe. Subpart B - listing of specific substances affirmed as GRAS. Sec. 184.1400 Lecithin. Available at: https:
Garlic 154 references
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- McMahon FG, Vargas R. Can garlic lower blood pressure? A pilot study. Pharmacotherapy 1993;13:406-7. DOI
- Auer W, Eiber A, Hertkorn E, et al. Hypertension and hyperlipidaemia: garlic helps in mild cases. Br J Clin Pract Suppl 1990;69:3-6.
- Garty BZ. Garlic burns. Pediatrics 1993;91:658-9.
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- Burnham BE. Garlic as a possible risk for postoperative bleeding. Plast Reconstr Surg 1995;95:213.
- Sunter WH. Warfarin and garlic. Pharm J 1991;246:722.
- Berthold HK, Sudhop T, von Bergmann K. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism. JAMA 1998;279:1900-2.
- Steiner M, Khan AH, Holbert D, Lin RI. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr 1996;64:866-70. PubMed
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