No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Glutathione 500 mg Ingredients & Drug Interactions

by Swanson

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

L-Glutathione 500 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, skin lightening or brightening, detoxification support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Glutathione 500 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: Setria Glutathione, a form of glutathione — a compound your cells make naturally and use to protect themselves from damage. The capsule also contains inactive ingredients (hypromellose, rice flour, and calcium laurate), which are fillers and binders that help hold the capsule together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Glutathione's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy detoxification and immune health.
  • We looked for evidence on: Cirrhosis, Nonalcoholic fatty liver disease (NAFLD), Chronic fatigue syndrome (CFS), Liver function, Oxidative stress.
  • The closest evidence on file: Glutathione is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS) (Natural Medicines).
  • Also on file: Glutathione is rated "Insufficient Reliable Evidence To Rate" for Cirrhosis, Nonalcoholic fatty liver disease (NAFLD).

The evidence for glutathione is mixed and incomplete. It's rated possibly effective for protection against nerve damage from the chemotherapy drug cisplatin (Platinol).

For everything else this product is marketed for — fatty liver disease, Alzheimer's disease, athletic performance, and cataracts — the data we hold shows insufficient reliable evidence to say whether it works.

The evidence, ingredient by ingredient Glutathione

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oral glutathione appears generally well tolerated in the short term, but long-term safety data are limited. One important caution: if you have asthma, inhaled glutathione can narrow your airways and cause shortness of breath or cough — though this product is a capsule taken by mouth, so that's a concern mainly for other forms.

During pregnancy, there isn't enough reliable safety information, so the data advises against it unless your doctor advises otherwise. The same applies during breastfeeding — there isn't enough data to know either way, so caution and avoidance are advised.

Side effects, ingredient by ingredient Glutathione

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we checked. Still, run your exact medications through the search tool on this page, or ask your pharmacist to confirm before you start.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

This product may be worth considering if you're looking into cisplatin protection and your oncologist agrees. For other uses — brain health, liver support, exercise — the evidence hasn't been established yet.

Talk with your doctor or pharmacist before starting, especially if you're pregnant, breastfeeding, or have asthma.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Glutathione 500 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614027456
Net contents 30 Veggie Cap(s)
Market status On market
Date entered into DSLD Sep 21, 2018
DSLD ID 181495
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Glutathione 500 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
UPC/BARCODE
087614027456
IngredientAmount% DV
Setria Glutathione500 mg--

Other ingredients: Hypromellose, Rice Flour, Calcium Laurate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Supports healthy detoxification

Promotes immune health Science-Backed Quality Since 1969

Antioxidant support Maximum strength

Formula

Features Setria Glutathione, which increases gluthione levels

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one veggie capsule per day with water.

Brand IP Statement(s)

Setria is a registered trademark of Kyowa Hakko Bio Co., Ltd.

Precautions

Warning: For adults only.

Consult your physician before using this or any product if you are pregnant or nursing, taking medication or have a medical condition.

Keep out of reach of children.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General

SWU745 Rev 0 02 14 18

See for yourself

L-Glutathione 500 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Glutathione 500 mg by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Amounts shown are per serving.

Setria Glutathione

No known
interactions
500 mg per serving Form: L-Glutathione

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefit...

Setria Glutathione monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Flour, Calcium Laurate. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Glutathione 500 mg by Swanson Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Glutathione 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Glutathione 500 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

L-Glutathione 500 mg by Swanson: Common Questions

Does L-Glutathione 500 mg by Swanson interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Glutathione 500 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Glutathione 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant?
The safety data aren't clear enough. There isn't enough reliable information to know either way during pregnancy, so the data advise against it unless your doctor specifically says it's okay for you. Talk with your doctor or pharmacist before taking it.
What is glutathione and what does it do?
Glutathione is a compound your own cells make and use to protect themselves from damage. This product gives you an extra dose of it as a supplement, though the evidence for what that extra dose accomplishes is still limited for most uses.
Does this product actually work?
It's rated possibly effective for protecting nerves during a specific chemotherapy drug (cisplatin). For everything else — Alzheimer's disease, fatty liver disease, athletic performance, cataracts — the evidence is too thin to say it works or doesn't work yet.
What are the inactive ingredients?
The capsule contains hypromellose, rice flour, and calcium laurate — fillers and binders that have no active role in the supplement.
Can I take this if I have asthma?
This product is a capsule you swallow, so asthma isn't a concern for this form. If you ever use inhaled glutathione, that's when airway narrowing and shortness of breath become a risk for people with asthma.
Is it safe to use long-term?
Short-term use appears well tolerated, but there isn't much data on long-term safety. If you're thinking of taking it regularly for weeks or months, ask your doctor or pharmacist whether that makes sense for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Glutathione 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Glutathione 500 mg label
Go deeper

The Full Monographs Behind L-Glutathione 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Glutathione 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutathione 1 reference
  1. Marrades RM, Roca J, Barbera JA, et al. Nebulized glutathione induces bronchoconstriction in patients with mild asthma. Am J Respir Crit Care Med 1997;156(2 Pt 1):425-30. PubMed

See these in context on the Glutathione monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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