L-Glycine Ingredients & Drug Interactions
by Hard Rhino
What is this page for?
First and foremost: checking L-Glycine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Glycine is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Glycine by Hard Rhino
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Glycine by Hard Rhino — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Glycine by Hard Rhino
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-glycine, a naturally occurring amino acid. There are no inactive ingredients listed — it's just the amino acid in powder form.
Does it work?
Moderate evidence
L-glycine is possibly effective for schizophrenia, though the research is mixed — in particular, the interaction data shows that adding it to clozapine therapy actually worsened symptoms in a small study. For other uses listed here — 3-phosphoglycerate dehydrogenase deficiency, ADHD, benign prostatic hyperplasia, and cystic fibrosis — we don't yet have enough reliable evidence to say whether it works.
How safe is it?
Well-documented data
L-glycine is generally well tolerated at typical doses, though long-term safety data are limited. Rare side effects include mild sedation, soft stools, nausea, vomiting, and upper GI tract discomfort — these resolve quickly if you stop taking it.
Other effects like irritability, insomnia, fatigue, memory impairment, headache, dry mouth, and sensory changes have been reported, but we can't be sure they're caused by the glycine. We don't have enough reliable safety data for use in pregnancy or while breastfeeding — talk with your doctor or pharmacist if you're considering it during either time.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril) for schizophrenia, talk with your doctor or pharmacist before adding L-glycine — the combination has been shown to worsen schizophrenia symptoms in a small study.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
L-glycine may be worth considering if your doctor recommends it for schizophrenia, but the research is complicated by that interaction with clozapine. If you take clozapine or any other antipsychotic, check with your doctor or pharmacist before starting — they know your full medication picture and can tell you whether it's the right call for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Glycine, straight from the product label.
| Brand | Hard Rhino |
|---|---|
| Barcode (UPC) | 798711500055 |
| Net contents | 5 kg; 11 lbs |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2017 |
| DSLD ID | 72075 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Glycine by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
-Non-GMO -Gluten free -Allergen free
Allergens: This product contains no soy, dairy, dairy byproducts, eggs, shellfish, wheat, gluten, tree nuts, or sesame seeds.
General Statements
Bulk pail - Best value - Scoop inside - 5000 servings
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 1 rounded scoop (~1 gram) mixed with 8 ounces of water or suitable beverage. Taken 1-3 times daily or as directed by your qualified health professional.
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.
Precautions
Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Always consult with a qualified health physician before taking any new dietary supplement.
Do not use or consume if seal is broken.
FDA Statement of Identity
Dietary Supplement
Storage
Storage: Store in a cool, dry place. Re-seal inner bag immediately after use to preserve freshness.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Glycine by Hard Rhino label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Glycine by Hard Rhino
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Gram(s) Dosage formPowder Servings per container5000 Amounts shown are per serving.
L-Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
L-Glycine monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
L-Glycine by Hard Rhino Drug Interactions
HelloPharmacist Interaction Report
Hard Rhino's L-Glycine through its single active ingredient has one documented interaction, and it's a moderate-severity one.
If you take clozapine (Clozaril) for schizophrenia, adding glycine may actually worsen your symptoms. A small clinical trial showed that when patients already on clozapine added glycine, their schizophrenia symptoms got worse compared to clozapine alone — we don't yet know exactly why this happens.
Read the full breakdown — every affected drug type, severity by severity
Although this is the only medication interaction we have data for, it's a real concern if clozapine is part of your regimen. Before you start this product, check with your doctor or pharmacist, especially if you're on any antipsychotic medication.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Glycine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Glycine interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Glycine interact with drugs. Each result below shows which ingredient is responsible. L-Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with L-Glycine — through 1 ingredient. Tap an ingredient for the detail:
L-glycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full L-glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Glycine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for L-Glycine, from the product label.
Hard Rhino
See all Hard Rhino products- Name
- Guardian Wholesale
- City
- Phoenix
- State
- AZ
- ZipCode
- 85085
- Phone Number
- (866)961-8378
- Web Address
- HardRhino.com
L-Glycine by Hard Rhino: Common Questions
Does L-Glycine by Hard Rhino interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is L-glycine safe to take during pregnancy or while breastfeeding?
What side effects might I experience?
Does L-glycine actually work for schizophrenia?
What is L-glycine, and what does it do in the body?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Glycine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Glycine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Glycine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC