L-Glycine Ingredients & Drug Interactions
by Hard Rhino
What is this page for?
First and foremost: checking L-Glycine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Glycine is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Glycine by Hard Rhino
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Glycine by Hard Rhino — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Glycine by Hard Rhino
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-Glycine, an amino acid. There are no other active ingredients.
The powder form is pure glycine with no inactive fillers or additives listed.
Does it work?
Moderate evidence
L-Glycine is rated possibly effective for schizophrenia based on available evidence. For other uses — including 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, attention deficit-hyperactivity disorder (ADHD), benign prostatic hyperplasia (BPH), and cystic fibrosis — the evidence on file is insufficient to rate it, meaning we don't have enough reliable data to say whether it works for those conditions.
How safe is it?
Well-documented data
L-Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Rare side effects include mild sedation, soft stools, nausea, vomiting, upper stomach discomfort, and dry mouth — all of which clear quickly if you stop taking it.
Irritability, insomnia, fatigue, memory problems, headache, and sensory changes have been reported, though whether glycine caused them is unclear. There isn't enough reliable safety data to know how safe it is in pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized advice if either applies to you.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril), an antipsychotic for schizophrenia, check with your doctor or pharmacist before using this product — it may decrease clozapine's effectiveness and worsen schizophrenia symptoms. For other medications, no interactions are documented in our data, though that's not a guarantee none exist.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
L-Glycine is a simple amino acid supplement with limited long-term safety data. If you take clozapine for schizophrenia, you need to clear this with your prescriber first because it may worsen symptoms.
Otherwise, it's generally well tolerated, though effectiveness for most conditions isn't well established. Talk it over with your own doctor or pharmacist before starting, especially if you're on prescription medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Glycine, straight from the product label.
| Brand | Hard Rhino |
|---|---|
| Barcode (UPC) | 818136459513 |
| Net contents | 500 Gram(s); 1.1 lbs |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2017 |
| DSLD ID | 72614 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Glycine by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
No added fillers
Allergens: This product contains no soy, dairy, dairy byproducts, eggs, shellfish, wheat, gluten, tree nuts, or sesame seeds.
This is a non-GMO ingredient.
General Statements
Only pure ingredients
Pure powder
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 1000 mg (~1/4 tsp) with 8 ounces of water or suitable beverage. Taken 1-3 times daily or as directed by your qualified health professional.
1 Carefully measure out suggested serving size using a microscale. 2 Add to preferred beverage. 3 Mix well. 4 Drink within 10-15 minutes. How to use
Storage: Store in a cool, dry place. Re-seal zipper immediately after use to preserve freshness.
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.
Precautions
Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Always consult with a qualified health physician before taking any new dietary supplement.
Do not use or consume if pressure seal is broken.
Do not use or consume if seal is broken.
Seals/Symbols
Lab tested for purity and quality
Packaged in USA
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Glycine by Hard Rhino label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Glycine by Hard Rhino
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Gram(s) Dosage formPowder Servings per container500 Amounts shown are per serving.
L-Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
L-Glycine monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
L-Glycine by Hard Rhino Drug Interactions
HelloPharmacist Interaction Report
L-Glycine by Hard Rhino has one documented interaction with a medication.
The concern is with clozapine (Clozaril), an antipsychotic used for schizophrenia. Adding glycine to clozapine therapy may worsen schizophrenia symptoms, though the exact mechanism isn't understood.
This is a Moderate-severity interaction based on a small clinical study in patients with schizophrenia.
Read the full breakdown — every affected drug type, severity by severity
If you take clozapine, check with your doctor or pharmacist before starting L-Glycine — even though this supplement is otherwise generally well tolerated. The research on this pairing is limited, so your prescriber needs to know about it.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Glycine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Glycine interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Glycine interact with drugs. Each result below shows which ingredient is responsible. L-Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with L-Glycine — through 1 ingredient. Tap an ingredient for the detail:
L-glycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full L-glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Glycine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for L-Glycine, from the product label.
Hard Rhino
See all Hard Rhino products- Name
- Guardian Wholesale
- Street Address
- 1607 West Whispering Wind Drive
- City
- Phoenix
- State
- AZ
- ZipCode
- 85085
- Phone Number
- (866) 961-8378
- Web Address
- HardRhino.com
L-Glycine by Hard Rhino: Common Questions
Does L-Glycine by Hard Rhino interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take L-Glycine if I'm pregnant?
Can I take L-Glycine while breastfeeding?
What are the most common side effects?
Does L-Glycine actually work for schizophrenia?
Is there anything in this powder besides glycine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Glycine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Glycine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Glycine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC