L-Lysine 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Lysine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine 500 mg is a dietary supplement by California Gold Nutrition with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are AjiPure. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine 500 mg by California Gold Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine 500 mg by California Gold Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Lysine 500 mg by California Gold Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-lysine (500 mg per capsule), an amino acid your body uses to build and repair proteins. The inactive ingredients are Modified Cellulose, Microcrystalline Cellulose, Silicon Dioxide, and Magnesium Stearate — these are fillers and binders that hold the capsule together.
Does it work?
Moderate evidence
L-lysine is possibly effective for cold sores (herpes labialis) — the evidence suggests it may help, though more research would strengthen that finding. For child growth, pressure ulcers, and diabetic foot ulcers, the evidence isn't established in our data, so we can't say whether it works for those uses.
How safe is it?
Well-documented data
Lysine is generally well tolerated at typical doses. At higher amounts, it may cause stomach upset, abdominal pain, diarrhea, or indigestion — and long-term safety at high doses hasn't been well studied.
There is one case report of oral lysine linked to kidney inflammation that progressed to chronic kidney failure, though this is extremely rare. During pregnancy, lysine from food is fine, but supplement safety hasn't been well studied — talk with your doctor before taking it.
For breastfeeding, there isn't enough reliable information yet, so caution is advised; check with your doctor or pharmacist for personalized guidance.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist (medications used for certain digestive disorders), check with your doctor or pharmacist before taking this product — lysine may reduce its effects. Altogether, these interactions span 1 individual medication.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.
L-lysine may help with cold sores and is generally well tolerated at typical doses. If you take a 5-HT4 agonist or are pregnant or breastfeeding, check with your doctor or pharmacist before starting.
Use the medication checker on this page to confirm your prescriptions are clear, and talk it over with your healthcare provider if you have questions.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine 500 mg, straight from the product label.
| Brand | California Gold Nutrition |
|---|---|
| Barcode (UPC) | 898220011322 |
| Net contents | 60 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 299650 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine 500 mg by California Gold Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| AjiPure | 500 mg | -- |
Other ingredients: Modified Cellulose, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested usage: Take 1 capsule daily, on an empty stomach. Best when taken as directed by a qualified healthcare professional.
Precautions
Warning: Keep out of reach of children.
Pregnant or lactating women, the chronically ill, elderly, individuals under the age of 18, those taking prescription medications (e.g., blood thinners) as well as those with a physician-diagnosed medical condition should consult with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements.
Pregnant or lactating women, the chronically ill, elderly, individuals under the age of 18, those taking prescription medications (e.g., blood thinners) as well as those with a physician-diagnosed medical condition should consult with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements.
Sealed for your protection. Do not use if seal is missing or broken.
This product is not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in a third-party, audited and registered cGMP compliant facility that may process other products that contain these allergens or ingredients.
Storage
Best stored at controlled room temperature 20 degrees C to 25 degrees C (68 degrees F to 77 degrees F). Improper storage conditions, such as extended exposure to direct sunlight, high heat & humidity can cause product degradation over time.
Formula
AjiPure Amino Acids
Brand IP Statement(s)
AjiPure is a registered trademark of Ajinomoto Co., Inc. California Gold Nutrition is a registered trademark of Madre Labs, LLC
Formulation
Formulated to contain No Gluten No GMOs No Soy
This product is not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten.
FDA Statement of Identity
Dietary Supplement
General Statements
100% Gold Guarantee All California Gold Nutrition products come with a 100% Gold Guarantee. If you are not completely satisfied with your purchase, return the unused portion within 90 days for a full refund.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine 500 mg by California Gold Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine 500 mg by California Gold Nutrition
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
AjiPure
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
AjiPure monograph & interactionsOther (inactive) ingredients: Modified Cellulose, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
L-Lysine 500 mg by California Gold Nutrition Drug Interactions
HelloPharmacist Interaction Report
L-Lysine 500 mg by California Gold Nutrition has one documented interaction, through its lysine content and 5-HT4 agonists (a class of medications used mainly for digestive disorders).
The interaction is Minor in severity: lysine may theoretically reduce how well these drugs work.
Read the full breakdown — every affected drug type, severity by severity
Animal studies suggest that lysine acts as a partial blocker of serotonin receptor 4, which is the mechanism these medications rely on. If you take a 5-HT4 agonist, check with your doctor or pharmacist before starting lysine to make sure the timing and dose won't interfere with your treatment.
Additionally, use the medication checker on this page to search your exact prescriptions and see whether lysine is a concern for you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine 500 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Lysine 500 mg interact with drugs. Each result below shows which ingredient is responsible. AjiPure
TegaserodZelnorm
How Tegaserod interacts with L-Lysine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Ajipure5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full Ajipure + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
AjiPure
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine 500 mg, from the product label.
California Gold Nutrition
See all California Gold Nutrition products- Name
- Madre Labs, LLC
- Street Address
- 301 North Lake Avenue, Suite 500
- City
- Pasadena
- State
- CA
- ZipCode
- 91101
- Web Address
- www.calgn.com
L-Lysine 500 mg by California Gold Nutrition: Common Questions
Does L-Lysine 500 mg by California Gold Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will L-lysine help my cold sores?
Can I take L-lysine if I'm pregnant?
Is it safe to take L-lysine while breastfeeding?
What side effects might I get from L-lysine?
How much L-lysine should I take?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Lysine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC