L-Lysine 500 mg Ingredients & Drug Interactions
by Nature Made
What is this page for?
First and foremost: checking L-Lysine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine 500 mg is a dietary supplement by Nature Made with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine 500 mg by Nature Made
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine 500 mg by Nature Made — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of L-Lysine 500 mg by Nature Made
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-lysine, an amino acid your body uses for building proteins and immune function. Each tablet or pill delivers 500 mg.
The inactive ingredients are cellulose gel, stearic acid, methylcellulose, silicon dioxide, croscarmellose sodium, hypromellose, magnesium stearate, and polyethylene glycol — these are fillers and binders that help form and hold the tablet together.
Does it work?
Not established
L-lysine is possibly effective for cold sores (herpes labialis), meaning some evidence supports its use, though the strength of that evidence is modest. For child growth, pressure ulcers, and diabetic foot ulcers, we don't have enough reliable evidence to know whether it works — these uses aren't established in the data we hold.
How safe is it?
Well-documented data
L-lysine is generally well tolerated at typical doses. High amounts may cause stomach upset, and long-term safety at high intakes hasn't been thoroughly studied.
The most common side effects reported are abdominal pain, diarrhea, and indigestion. One rare case of kidney inflammation has been reported with long-term use, though it's not clear how often this might occur.
Supplement safety in pregnancy and breastfeeding hasn't been well studied, so there isn't enough data to know either way. If you're pregnant or nursing and want to take L-lysine, talk with your doctor or pharmacist first.
Lysine from food is considered fine, but supplements are a different question.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist — a medication for certain digestive issues — check with your doctor or pharmacist before using this product; L-lysine may reduce its effectiveness. No other medication interactions are documented in our data for the ingredients we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.
L-lysine is a reasonable choice if you're dealing with cold sores and want to try a supplement with some evidence behind it. If you take a 5-HT4 agonist, check with your doctor or pharmacist first.
Pregnant or nursing people should talk it over with their own healthcare provider before starting, since the safety data in those situations is limited.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine 500 mg, straight from the product label.
| Brand | Nature Made |
|---|---|
| Barcode (UPC) | 031604016814 |
| Net contents | 100 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2018 |
| DSLD ID | 179509 |
| Product type | Amino Acid/protein |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine 500 mg by Nature Made, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Lysine | 500 mg | -- |
Other ingredients: Cellulose Gel, Stearic Acid, Methylcellulose, Silicon Dioxide, Croscarmellose Sodium, Hypromellose, Magnesium Stearate, Polyethylene Glycol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General
List No. 1681 L200 Cat. 653 5A006
FDA Statement of Identity
Dietary Supplement
General Statements
Actual size
Supports synthesis of proteins - L-Lysine, an essential amino acid, plays a key role in the makeup of body proteins.
L-Lysine Tablets are made to Nature Made’s guaranteed purity and potency standards.
Formulation
No color added No artificial flavors No preservatives No yeast Gluten free
Suggested/Recommended/Usage/Directions
Suggested use: Take one tablet daily with a meal. For easier swallowing, take with water before and during ingestion.
Storage
Keep bottle tightly closed. Store in a cool, dry place, out of reach of children.
Precautions
Store in a cool, dry place, out of reach of children.
Do not use if imprinted seal under cap is broken or missing.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine 500 mg by Nature Made label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine 500 mg by Nature Made
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: Cellulose Gel, Stearic Acid, Methylcellulose, Silicon Dioxide, Croscarmellose Sodium, Hypromellose, Magnesium Stearate, Polyethylene Glycol. These complete the product’s ingredient list but are not active constituents.
L-Lysine 500 mg by Nature Made Drug Interactions
HelloPharmacist Interaction Report
Nature Made L-Lysine 500 mg contains one active ingredient, L-lysine, which has a documented interaction with 5-HT4 agonists — a class of medications used for certain digestive conditions.
Animal studies suggest L-lysine may reduce how well these drugs work by partially blocking their target receptor.
Read the full breakdown — every affected drug type, severity by severity
This is a Minor interaction, meaning the effect is unlikely to be severe, but it's worth knowing about. If you take a 5-HT4 agonist, check with your doctor or pharmacist before starting L-lysine to see whether the two are right for you together.
Alaltogether, these interactions span 1 individual medication. Use the search tool below to look up your exact drugs and see if any are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine 500 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Lysine 500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with L-Lysine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine 500 mg, from the product label.
Nature Made
See all Nature Made products- Name
- Nature Made Nutritional Products
- City
- Mission Hills
- State
- CA
- ZipCode
- 91346-9606
- Phone Number
- 1-800-276-2878
- Web Address
- www.NatureMade.com
L-Lysine 500 mg by Nature Made: Common Questions
Does L-Lysine 500 mg by Nature Made interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will L-lysine help my cold sores?
What are the most common side effects?
Is it safe to take L-lysine while pregnant or breastfeeding?
Can I take this if I have kidney problems?
How much L-lysine should I take?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Lysine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC