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Dietary supplement

L-Lysine Ingredients & Drug Interactions

by AN Amazing Nutrition Amazing Formulas

L-Lysine label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Lysine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

L-Lysine is a dietary supplement by AN Amazing Nutrition Amazing Formulas with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against L-Lysine by AN Amazing Nutrition Amazing Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine by AN Amazing Nutrition Amazing Formulas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of L-Lysine by AN Amazing Nutrition Amazing Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-Lysine Hydrochloride, an amino acid your body uses for protein synthesis and immune function. Lysine is an essential amino acid, meaning your body can't make it on its own — you have to get it from food or supplements.

The powder form lets you mix it into water or another beverage.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune system and connective tissue support.
  • We looked for evidence on: Herpes labialis (cold sores), collagen synthesis, wound healing.
  • The strongest evidence on file: Lysine is rated "Possibly Effective" for Herpes labialis (cold sores) (Natural Medicines).

L-Lysine is possibly effective for herpes labialis (cold sores) according to the evidence we have on file. For other uses — helping child growth, treating pressure ulcers, or aiding diabetic foot ulcers — the evidence isn't established enough to rate, so we can't say whether it works for those.

The evidence, ingredient by ingredient Lysine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lysine is generally well tolerated at typical doses, though high amounts may cause stomach upset like abdominal pain, diarrhea, or indigestion. Long-term safety at high doses hasn't been well studied.

There's a single case report of oral lysine linked to a kidney condition, but that's rare. For pregnancy, the safety data on supplements isn't well studied — lysine from food is fine, but if you're pregnant or planning to be, check with your doctor before starting a supplement.

If you're breastfeeding, there isn't enough reliable information yet, so talk it over with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Lysine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lysine.
  • The most serious interaction on file is rated Minor.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take 5-HT4 agonists (gut-motility medications), check with your doctor or pharmacist before starting this supplement — lysine may reduce their effect, which is a Minor interaction.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

L-Lysine is a simple, single-ingredient supplement possibly effective for cold sores. If you take 5-HT4 agonists for gut motility, check with your doctor or pharmacist before adding it — it may blunt how those drugs work.

Anyone considering it during pregnancy or breastfeeding should talk it over with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Lysine, straight from the product label.

Brand AN Amazing Nutrition Amazing Formulas
Barcode (UPC) 810180028486
Net contents 500 Gram(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 251950
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Lysine by AN Amazing Nutrition Amazing Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
680 mg
Maximum serving Sizes:
680 mg
Servings per container
735
UPC/BARCODE
810180028486
IngredientAmount% DV
L-Lysine Hydrochloride680 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

We believe that Amazing Nutrition is the key for healthy living. We are passionate about bringing you the finest selection of products which can perfectly complement a healthy diet and active lifestyle.

Shop online at: amazingnutrition.com Call toll-free: 1-800-526-0177

US Standard Measuring Spoons Spoon Size (rounded) milligrams (mg) 1/8 teaspoon...338 1/4 teaspoon...677 1/2 teaspoon...1,355

Contents are sold by weight not volume. Some settling may occur.

Formulation

L-Lysine is an essential amino acid that they body uses to build proteins. As as amino acid, L-Lysine helps your body to produce proteins, enzymes, collagen and antibodies. L-Lysine supports healthy immune system, healthy connective tissues, healthy organs and respiratory health. L-Lysine may support weight management as it helps to convert fatty acids into energy and promotes lean muscle mass. L-Lysine may also support bone health by promoting the intestinal absorption of calcium.

Supports immune system & respiratory health Supports healthy connective tissues Supports calcium absorption

Contains No: Additives, sugar, milk, lactose, soy, gluten, wheat, tree nuts or eggs.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of reach of children

Do not use if safety seal is damaged or missing

Caution: Not intended for use by children under the age of 18, pregnant or lactating women or individuals with any known medical condition.

Caution: Not intended for use by children under the age of 18, pregnant or lactating women or individuals with any known medical condition.

Always consult with a qualified health care physician before taking any dietary supplements.

Storage

Store in a cool, dry place

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in USA GMP Good Manufacturing Practice Quality Product

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults 680 mg (1/4 teaspoon) mixed with 6 to 8 ounces of water or a suitable beverage. Take one (1) to two (2) times daily or as directed by a health care professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Lysine by AN Amazing Nutrition Amazing Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Lysine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Lysine by AN Amazing Nutrition Amazing Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size680 mg Dosage formPowder Servings per container735 Amounts shown are per serving.

L-Lysine Hydrochloride

Interacts with
1 drug
680 mg per serving

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine Hydrochloride monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Lysine by AN Amazing Nutrition Amazing Formulas Drug Interactions

Want to check YOUR meds against L-Lysine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Minor

Ingredients driving the most interactions

L-Lysine Hydrochloride 1

Individual Drug Interactions

The ingredients in L-Lysine interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in L-Lysine interact with drugs. Each result below shows which ingredient is responsible. L-Lysine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Lysine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Lysine, from the product label.

AN Amazing Nutrition Amazing Formulas

See all AN Amazing Nutrition Amazing Formulas products
Name
Amazing Nutrition
City
Jersey City
State
NJ
Phone Number
1-800-526-0177
Web Address
www.amazingnutrition.com
Pharmacist Counseling Corner

L-Lysine by AN Amazing Nutrition Amazing Formulas: Common Questions

Does L-Lysine by AN Amazing Nutrition Amazing Formulas interact with any medications?
Yes. Based on its ingredients, L-Lysine has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Lysine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my cold sores?
L-Lysine is possibly effective for herpes labialis (cold sores) based on the evidence we have. That said, results aren't guaranteed, and it's a good idea to talk it over with your pharmacist or doctor about what to expect and whether it fits your situation.
Can I take this while pregnant?
The safety data on lysine supplements during pregnancy isn't well studied yet. Lysine from food is fine, but before you start a supplement, check with your doctor first — they can give you personalized advice based on your health.
What are the side effects?
Lysine is generally well tolerated, but at high doses it may cause abdominal pain, diarrhea, or indigestion. Long-term safety at high amounts hasn't been well studied. If you notice stomach trouble, dial back the dose and talk to your pharmacist.
Is this safe while breastfeeding?
There isn't enough reliable information on lysine supplement use while breastfeeding, so caution is advised. Talk it over with your doctor or pharmacist — they can help you weigh the pros and cons for your situation.
What exactly is L-Lysine?
Lysine is an essential amino acid — a building block your body needs to make protein and support immune function, but can't produce on its own. You normally get it from foods like meat, eggs, and dairy; this powder is a concentrated supplement form.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Lysine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Lysine label
Go deeper

The Full Monographs Behind L-Lysine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph →
Sources

Sources & How We Checked

L-Lysine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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