L-Lysine/L-Proline Ingredients & Drug Interactions
by Roex
What is this page for?
First and foremost: checking L-Lysine/L-Proline against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine/L-Proline is a dietary supplement by Roex with 2 active ingredients. Its ingredients are commonly taken for joint and connective tissue support, skin health and wound healing, collagen production.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine/L-Proline by Roex
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine/L-Proline by Roex — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Lysine/L-Proline by Roex
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: L-lysine and L-proline, both amino acids. L-lysine is an amino acid your body gets from protein in food; the evidence suggests it may help with cold sores.
L-proline is another amino acid involved in collagen and connective tissue, though the evidence for its specific health roles is still being studied. The capsules also contain inactive ingredients—hydroxypropyl methylcellulose, silica, and magnesium stearate—which are fillers and binders that help hold the supplement together.
Does it work?
Not established
L-lysine is possibly effective for cold sores (herpes labialis). The evidence for its other claimed uses—including child growth, pressure ulcers, and diabetic foot ulcers—is insufficient to rate.
For L-proline, the evidence isn't established in our data for the uses it's marketed for: athletic performance, bone health (osteoporosis, osteopenia, fractures), and wound healing all lack reliable evidence to rate.
How safe is it?
Well-documented data
Both ingredients are generally well tolerated at typical doses. L-lysine may cause abdominal pain, diarrhea, or dyspepsia, especially at higher amounts, and long-term safety isn't well studied.
There's a single case report of high-dose lysine linked to kidney inflammation, though this is rare. L-proline has no adverse effects documented, but supplement safety at high doses hasn't been well studied.
For pregnancy: the data on supplemental lysine during pregnancy isn't well studied, so check with your doctor first. For breastfeeding: there isn't enough reliable information on either ingredient's safety during breastfeeding, so caution is advised and talking it over with your doctor or pharmacist is wise.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist medication (used for certain digestive conditions), mention this supplement to your pharmacist or doctor before you start—lysine may reduce how well the drug works. For any other medications you're on, you can search them in the tool on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.
This product is a reasonable choice if you're looking for lysine support for cold sores and want the amino acid pairing with proline. Both ingredients are generally well tolerated, though doses that are very high may cause digestive upset.
If you're pregnant, breastfeeding, or take a 5-HT4 agonist medication, talk it over with your doctor or pharmacist first to make sure it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine/L-Proline, straight from the product label.
| Brand | Roex |
|---|---|
| Barcode (UPC) | 645245331207 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 25, 2020 |
| DSLD ID | 211478 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine/L-Proline by Roex, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Proline | 400 mg | -- |
| L-Lysine | 225 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
L-Lysine is a necessary building block for all protein in the body. This essential amino acid plays a major role in calcium absorption, building muscle protein, and the body's production of hormones and enzymes. In addition, L-Lysine serves as a co-factor with vitamin C to support healthy cardiovascular function. L-Proline serves as a precursor to hydroxyproline which is an essential component of collagen tissues that helps them maintain their structural characteristics.
Free form amino acids
Precautions
Warning: Not intended for children.
Consult your physician prior to use if you are pregnant, nursing, have a medical condition or are taking medications.
Keep out of the reach of children.
Do not use if clear safety seal around bottle neck is broken or missing.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Forms collagen that supports joints, tendons and heart muscle Promotes a healthy immune system Aids in muscle recovery and tissue rejuvenation
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Adults, take 1 capsule twice daily, as a dietary supplement or as directed by your doctor.
Storage
Store at room temperature, in a dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine/L-Proline by Roex label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine/L-Proline by Roex
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Proline
No knowninteractions
Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of...
L-Proline monograph & interactionsL-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: Hydroxypropyl Methylcellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
L-Lysine/L-Proline by Roex Drug Interactions
HelloPharmacist Interaction Report
Roex L-Lysine/L-Proline contains L-lysine, which has one documented interaction.
L-lysine may reduce the effects of 5-HT4 agonists (a type of medication used for certain gastrointestinal conditions). Animal research suggests lysine blocks some activity of these drugs, though human evidence is limited and the interaction is rated Minor.
Read the full breakdown — every affected drug type, severity by severity
L-Proline, the other active ingredient, has no documented interactions with medications in our data.
Alone, this product poses a low interaction risk, but if you take a 5-HT4 agonist, mention this supplement to your pharmacist or doctor before starting it. You can also search your exact medications in the tool on this page to see the full picture.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine/L-Proline?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine/L-Proline interact with 1 drug. Click any drug to see the details.
1 of the 2 ingredients in L-Lysine/L-Proline interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with L-Lysine/L-Proline — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine/L-Proline with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine/L-Proline, from the product label.
Roex
See all Roex products- Name
- BIN Science LLC
- Street Address
- 8310 South Valley Highway, St. 300
- City
- Englewood
- State
- CO
- ZipCode
- 80112
- Phone Number
- 800-645-0010
- Web Address
- www.roex.com
L-Lysine/L-Proline by Roex: Common Questions
Does L-Lysine/L-Proline by Roex interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does L-lysine really help with cold sores?
What is L-proline, and what is it supposed to do?
Can I take this if I'm pregnant?
Are there any side effects?
Is this safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine/L-Proline is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine/L-Proline’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proline
Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of collagen, but strong human evidence that...
Read the full Proline monograph → Herb & supplement monographLysine
Interacts with 1 drugLysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...
Read the full Lysine monograph →Sources & How We Checked
L-Lysine/L-Proline's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proline 4 references
- Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
- Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
- Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
- Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC