Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

L-Lysine Plus Ingredients & Drug Interactions

by Nutri-West

L-Lysine Plus label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Lysine Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

L-Lysine Plus is a dietary supplement by Nutri-West with 5 active ingredients. Its ingredients are commonly taken for general energy and vitality, immune support, nutritional supplement.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bee Pollen, L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against L-Lysine Plus by Nutri-West

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine Plus by Nutri-West — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of L-Lysine Plus by Nutri-West

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Tissue concentrates” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

L-Lysine Plus contains 5 ingredients total. The active ones are bee pollen, which is a mixed nutrient product from honeybees; L-lysine, an amino acid (building block protein); and three tissue concentrates — Adrenal, Parotid, and Pituitary — which are concentrated extracts from animal tissues.

There are no inactive fillers or binders listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: herpes labialis and cold sore support.
  • We looked for evidence on: Herpes labialis (cold sores), Canker sores, Genital herpes, Viral infection.
  • The strongest evidence on file: Lysine is rated "Possibly Effective" for Herpes labialis (cold sores) (Natural Medicines).
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Canker sores.

L-lysine is possibly effective for cold sores (herpes labialis); the evidence for other uses — child growth, pressure ulcers, and diabetic foot ulcers — is insufficient to rate. Bee pollen's evidence for athletic performance is listed as possibly ineffective, and for hay fever, breast cancer hot flashes, amenorrhea, and prostate health, there isn't enough reliable evidence to say whether it works.

We hold no effectiveness data for the tissue concentrates.

The evidence, ingredient by ingredient Bee Pollen Lysine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bee pollen is generally well tolerated by most people but can trigger allergic reactions, sometimes severe — especially in people with pollen allergies (ragweed, chrysanthemums, daisies, and similar plants). Serious but rare adverse effects include acute hepatitis, kidney damage, and anaphylaxis.

L-lysine is generally well tolerated at normal doses; the most common side effects are stomach upset, diarrhea, and abdominal pain. High amounts or long-term use safety isn't well studied.

One rare case linked high-dose lysine to kidney damage progressing to chronic kidney failure. Bee pollen is rated possibly unsafe in pregnancy and should be avoided because it may stimulate the uterus; safety during breastfeeding is unknown, so it should be avoided then too.

L-lysine safety in pregnancy and breastfeeding as a supplement is not well studied — the amino acid from food is fine, but if you're pregnant or nursing, talk with your doctor or pharmacist before taking the supplement.

Side effects, ingredient by ingredient Bee Pollen Lysine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bee Pollen, Lysine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product with your doctor or pharmacist if you take warfarin (Coumadin) or any other blood thinner — bee pollen may increase bleeding risk. Also check if you take any drug for digestive motility or gut movement, since L-lysine may reduce how well those work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-Lysine Plus may be worth considering if you get cold sores, since L-lysine is possibly effective for that. If you take warfarin or any medication for digestive motility, you'll need to check with your doctor or pharmacist before starting this product because of documented interactions.

Pregnant or nursing? Same conversation needed — the safety data on supplement doses isn't there yet.

Run your full medication list through the interaction checker on this page before you take it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Lysine Plus, straight from the product label.

Brand Nutri-West
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Nov 25, 2013
DSLD ID 28014
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Lysine Plus by Nutri-West, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
Bee Pollen250 mg--
L-Lysine400 mg--
Adrenal15 mg--
Parotid5 mg--
Pituitary5 mg--
Tissue concentrates0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

1594 MFG12/2010

FOR DISTRIBUTION BY HEALTH CARE PROFESSIONALS ONLY.

Manufactured under strict GMP and USP guidelines.

"When You Want The Best"

Formulation

Contains no starch, salt, sugar, wheat, corn, yeast, soy, or preservatives.

Precautions

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT OUTER SEAL - DO NOT USE IF BROKEN.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for use: One tablet daily, or as directed.

General

Product # 1440

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Lysine Plus by Nutri-West label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Lysine Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Lysine Plus by Nutri-West

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bee Pollen

Interacts with
2 drugs
250 mg per serving

Bee pollen is a nutrient-rich product collected by bees and marketed as a 'superfood' for energy and immune support, but solid human evidence for most...

Bee Pollen monograph & interactions

L-Lysine

Interacts with
1 drug
400 mg per serving

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine monograph & interactions

Tissue concentrates

0 NP per serving
  • › Adrenal
  • › Parotid
  • › Pituitary
Interaction report

L-Lysine Plus by Nutri-West Drug Interactions

Want to check YOUR meds against L-Lysine Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
2 Moderate 1 Minor

Ingredients driving the most interactions

Bee Pollen 2
L-Lysine 1

Individual Drug Interactions

The ingredients in L-Lysine Plus interact with 3 drugs. Click any drug to see the details.

2 of the 5 ingredients in L-Lysine Plus interact with drugs. Each result below shows which ingredient is responsible. Bee Pollen L-Lysine

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Lysine Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bee Pollen1 drug type · 2 drugs

Warfarin (Coumadin)

There is some concern that bee pollen might interact with warfarin and increase the risk of bleeding.
In one case report, a patient on warfarin had a stable international normalized ratio (INR) of 1.9-3.3 for 9 months. The patient's INR was found to be 7.1 after starting bee pollen granules one teaspoon twice daily for approximately one month. The patient's warfarin dose was decreased by approximately 11% in order to return the INR to the therapeutic range while continuing the bee pollen supplement.

Likelihood Possible Evidence D
Bee Pollen full monograph & interactions

L-Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Lysine Plus, from the product label.

Nutri-West

See all Nutri-West products
Name
Nutri-West
City
Douglas
State
Wy
ZipCode
82633
Pharmacist Counseling Corner

L-Lysine Plus by Nutri-West: Common Questions

Does L-Lysine Plus by Nutri-West interact with any medications?
Yes. Based on its ingredients, L-Lysine Plus has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Lysine Plus contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will L-Lysine Plus help my cold sores?
L-lysine is possibly effective for cold sores (herpes labialis) based on the evidence we have. Results aren't guaranteed, but it's worth discussing with your doctor or pharmacist to see if it makes sense for you.
Can I take this if I'm allergic to pollen?
No — bee pollen can trigger serious allergic reactions in people with pollen allergies, especially to ragweed, chrysanthemums, daisies, and similar plants. If you have any seasonal pollen allergies, avoid this product or talk with your doctor first.
What are the most common side effects of L-Lysine Plus?
L-lysine may cause stomach upset, diarrhea, and abdominal pain, though it's generally well tolerated at typical doses. Bee pollen is also well tolerated by most people but can rarely trigger serious allergic reactions.
Can I take this while pregnant?
Bee pollen is rated possibly unsafe in pregnancy because it may stimulate the uterus, so it should be avoided. L-lysine safety as a supplement in pregnancy isn't well studied — the amino acid in food is fine, but talk with your doctor or pharmacist before taking the supplement dose.
Is it safe to use while breastfeeding?
Bee pollen should be avoided while breastfeeding because safety data is unknown. L-lysine also lacks enough reliable information on breastfeeding safety, so caution is advised — check with your doctor or pharmacist.
What about the other ingredients — Adrenal, Parotid, and Pituitary tissue concentrates?
We don't hold interaction data for these three ingredients, so we can't check them. Mention them when you review this product with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Lysine Plus label
Go deeper

The Full Monographs Behind L-Lysine Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bee Pollen

Interacts with 2 drugs

Bee pollen is a nutrient-rich product collected by bees and marketed as a 'superfood' for energy and immune support, but solid human evidence for most of these claims is lacking. It can caus...

Read the full Bee Pollen monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph →
Sources

Sources & How We Checked

L-Lysine Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bee Pollen 15 references
  1. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  4. Shad JA, Chinn CG, Brann OS. Acute hepatitis after ingestion of herbs. South Med J 1999;92:1095-7. PubMed
  5. Puente S, Iniguez A, Subirats M, et al. [Eosinophilic gastroenteritis caused by bee pollen sensitization]. Med Clin (Barc) 1997;108:698-700.
  6. Winther K, Hedman C. Assessment of the Effects of the Herbal Remedy Femal on the Symptoms of Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. Curr Ther Res Clin Exp 2002;63:344-53. DOI
  7. Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol 1979;64:270-4. PubMed
  8. Hurren KM, Lewis CL. Probable interaction between warfarin and bee pollen. Am J Health Syst Pharm 2010;67:2034-7. PubMed
  9. Akiyasu T, Paudyal B, Paudyal P, et al. A case report of acute renal failure associated with bee pollen contained in nutritional supplements. Ther Apher Dial 2010;14:93-7. PubMed
  10. Greenberger, P. A. and Flais, M. J. Bee pollen-induced anaphylactic reaction in an unknowingly sensitized subject. Ann.Allergy Asthma Immunol 2001;86(2):239-242. PubMed
  11. Lin FL, Vaughan TR, Vandewalker ML, et al. Hypereosinophilia, neurologic, and gastrointestinal symptoms after bee-pollen ingestion. J Allergy Clin Immunol 1989;83(4):793-796. PubMed
  12. Mansfield LE, Goldstein GB. Anaphylactic reaction after ingestion of local bee pollen. Ann Allergy 1981;47(3):154-156.
  13. Choi JH, Jang YS, Oh JW, Kim CH, Hyun IG. Bee pollen-induced anaphylaxis: a case report and literature review. Allergy Asthma Immunol Res 2015 Sep;7(5):513-7. PubMed
  14. Nonotte-Varly C. Allergenicity of Artemisia contained in bee pollen is proportional to its mass. Eur Ann Allergy Clin Immunol 2015;47(6):218-24.
  15. Leang ZX, Thalayasingam M, O'Sullivan M. A paediatric case of exercise-augmented anaphylaxis following bee pollen ingestion in Western Australia. Asia Pac Allergy. 2022 Jul 12;12(3):e23. PubMed

See these in context on the Bee Pollen monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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