L-Methylfolate 15 mg + Glycine Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Methylfolate 15 mg + Glycine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Methylfolate 15 mg + Glycine is a dietary supplement by aSquared Nutrition with 2 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Methylfolate 15 mg + Glycine by aSquared Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Methylfolate 15 mg + Glycine by aSquared Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Methylfolate 15 mg + Glycine by aSquared Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: L-Methylfolate (a form of folate, a B vitamin) and L-Glycine (an amino acid). The inactive ingredients are rice flour and cellulose, which are fillers and capsule material.
Does it work?
Moderate evidence
L-Glycine is possibly effective for schizophrenia, though evidence is limited. For other uses listed — 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, ADHD, benign prostatic hyperplasia (BPH), and cystic fibrosis — there isn't enough reliable evidence to rate whether glycine works.
We hold no effectiveness data for L-Methylfolate in our records.
How safe is it?
Well-documented data
L-Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Rarely, people have reported mild sedation, irritability, insomnia, fatigue, memory problems, headache, and sensory changes — though it's unclear whether glycine caused them.
Soft stools, nausea, vomiting, upper stomach discomfort, and dry mouth have also been reported rarely. These symptoms resolve quickly if you stop taking it.
There isn't enough reliable safety data for pregnancy or while breastfeeding. Talk with your doctor or pharmacist before taking this product if you're pregnant, planning to become pregnant, or breastfeeding.
Meds to double-check
Moderate interaction found
Clozapine (Clozaril) — a medication for schizophrenia — may become less effective if you add glycine. Talk with your doctor or pharmacist before combining them.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
If you take clozapine for schizophrenia, this product isn't right for you — glycine may make the medication less effective. For other situations, the long-term safety picture isn't complete, and we can't evaluate L-Methylfolate's usefulness from the data on file.
Check with your own doctor or pharmacist before starting, especially if you're on any medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Methylfolate 15 mg + Glycine, straight from the product label.
| Brand | aSquared Nutrition |
|---|---|
| Barcode (UPC) | X002UV9ADL |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 295347 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Methylfolate 15 mg + Glycine by aSquared Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Folate | 25000 mcg DFE | 6375% |
| L-Glycine | 250 mg | -- |
| L-Methylfolate | 15 mg | -- |
Other ingredients: Rice Flour, Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: Take 1 capsule per day with a meal, or as directed by your qualified healthcare professional.
Precautions
Caution: Do not exceed the recommended dose.
Not for use by children under 18 years of age.
Pregnant or nursing mothers, individuals taking any medications, individuals with a known medical condition, and individuals planning a medical procedure should consult a physician before using this or any dietary supplement.
Keep out of the reach of children.
Do not use if safety seal is damaged or missing.
Seals/Symbols
GMP Good Manufacturing Practice Quality Assured
USA Formulated
General Statements
Please recycle.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Extra strength Supports brain health Supports nerve health
Formula
Enhanced with L-Glycine
aSquared Nutrition is proud to offer an extra strength L-Methylfolate supplement enhanced with L-Glycine. Our formula contains 15 mg of L-Methylfolate and 250 mg of L-Glycine per vegetable capsule.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Methylfolate 15 mg + Glycine by aSquared Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Methylfolate 15 mg + Glycine by aSquared Nutrition
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetable Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Folate
- › L-Methylfolate
L-Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
L-Glycine monograph & interactionsOther (inactive) ingredients: Rice Flour, Cellulose. These complete the product’s ingredient list but are not active constituents.
L-Methylfolate 15 mg + Glycine by aSquared Nutrition Drug Interactions
HelloPharmacist Interaction Report
L-Methylfolate 15 mg + Glycine by aSquared Nutrition contains one ingredient with documented interactions: L-Glycine, which may reduce how well clozapine (Clozaril) works for schizophrenia.
A small study showed that adding glycine to clozapine therapy worsened schizophrenia symptoms compared to clozapine alone, though researchers aren't certain why this happens.
Read the full breakdown — every affected drug type, severity by severity
L-Methylfolate has no interaction data on file — we could not check it. Before you start this product, run your exact medications through the search tool on this page to see if any are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Methylfolate 15 mg + Glycine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Methylfolate 15 mg + Glycine interact with 1 drug. Click any drug to see the details.
1 of the 2 ingredients in L-Methylfolate 15 mg + Glycine interact with drugs. Each result below shows which ingredient is responsible. L-Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with L-Methylfolate 15 mg + Glycine — through 1 ingredient. Tap an ingredient for the detail:
L-glycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full L-glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Methylfolate 15 mg + Glycine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for L-Methylfolate 15 mg + Glycine, from the product label.
aSquared Nutrition
See all aSquared Nutrition products- Name
- aSquared Brands LLC
- Street Address
- 382 NE 191st Street, #98406
- City
- Miami
- State
- Florida
- ZipCode
- 33179
- Phone Number
- 1-800-557-4120
L-Methylfolate 15 mg + Glycine by aSquared Nutrition: Common Questions
Does L-Methylfolate 15 mg + Glycine by aSquared Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What does L-Glycine do?
What side effects does glycine have?
What about L-Methylfolate — does it interact with my medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Methylfolate 15 mg + Glycine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Methylfolate 15 mg + Glycine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Methylfolate 15 mg + Glycine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC