No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Ornithine-L-Aspartate Ingredients & Drug Interactions

by Allergy Research Group

Powder Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

L-Ornithine-L-Aspartate is a dietary supplement by Allergy Research Group with 1 active ingredient. Its ingredients are commonly taken for liver-related brain symptoms (hepatic encephalopathy), lowering blood ammonia levels, support in cirrhosis and fatty liver.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Ornithine-L-Aspartate by Allergy Research Group

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: L-ornithine-L-aspartate, an amino acid compound. It works by helping your body remove ammonia, a waste product that can build up when the liver isn't working well.

The product comes as a powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: liver support metabolite.
  • We looked for evidence on: Cirrhosis, Hepatic encephalopathy, ammonia metabolism, liver function, fatty liver disease.
  • The strongest evidence on file: L-ornithine-l-aspartate is rated "Possibly Effective" for Hepatic encephalopathy (Natural Medicines).
  • Also on file: L-ornithine-l-aspartate is rated "Insufficient Reliable Evidence To Rate" for Cirrhosis.

L-Ornithine-L-Aspartate is rated possibly effective for hepatic encephalopathy, a serious brain condition caused by liver disease where ammonia accumulates and interferes with mental function. For athletic performance, cachexia (muscle wasting), cirrhosis, and wound healing, the evidence isn't established in the data we hold — so we can't say whether it works for those uses.

The evidence, ingredient by ingredient L-ornithine-l-aspartate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Ornithine-L-Aspartate is generally well tolerated when taken by mouth or given intravenously. The most common side effects from intravenous use are cough, muscle cramps, nausea, and vomiting — slowing the infusion rate can help prevent nausea and vomiting.

Because this supplement is typically used under medical supervision for serious liver disease, don't self-treat a liver condition without talking to your doctor first. Safety hasn't been established in pregnancy, so it's best avoided unless your doctor directs otherwise.

There isn't enough data to know whether it's safe during breastfeeding — talk with your doctor or pharmacist before using it if you're nursing.

Side effects, ingredient by ingredient L-ornithine-l-aspartate

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for this ingredient. Before you start, check your exact medications with the tool on this page, and confirm with your own doctor or pharmacist that it's safe alongside what you take.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

L-Ornithine-L-Aspartate is an option if your doctor has recommended it for hepatic encephalopathy related to liver disease. Because it's meant for a serious condition that needs medical oversight, don't self-treat without professional guidance.

Check with your own doctor or pharmacist about whether it fits your situation and whether it interacts with anything you're taking.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Ornithine-L-Aspartate, straight from the product label.

Brand Allergy Research Group
Barcode (UPC) 713947761001
Net contents 100 Gram(s); 3.5 Oz(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 233287
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Ornithine-L-Aspartate by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 tsp
Maximum serving Sizes:
1 tsp
Servings per container
33
UPC/BARCODE
713947761001
IngredientAmount% DV
L-Ornithine-L-Aspartate3 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

L-ornithine-L-aspartate, a free form amino acid. High purity, well tolerated.

Suggested/Recommended/Usage/Directions

Suggested use As a dietary supplement, 1 rounded teaspoon one or two times daily, or as directed by a healthcare practitioner.

Storage

Keep in a cool, dry place, tightly capped.

FDA Disclaimer Statement

This statement has not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Liver Support Metabolite

Hypoallergenic

FDA Statement of Identity

Dietary Supplement

See for yourself

L-Ornithine-L-Aspartate by Allergy Research Group label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Ornithine-L-Aspartate by Allergy Research Group

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 tsp Dosage formPowder Servings per container33 Amounts shown are per serving.

L-Ornithine-L-Aspartate

No known
interactions
3 Gram(s) per serving

L-ornithine-L-aspartate (LOLA) is a combination of two amino acids studied mainly for lowering ammonia in people with liver disease and helping manage...

L-Ornithine-L-Aspartate monograph & interactions
Interaction report

L-Ornithine-L-Aspartate by Allergy Research Group Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Ornithine-L-Aspartate. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Ornithine-L-Aspartate, from the product label.

Allergy Research Group

See all Allergy Research Group products
Name
Allergy Research Group
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800-545-9960
Web Address
www.allergyresearchgroup.com
Pharmacist Counseling Corner

L-Ornithine-L-Aspartate by Allergy Research Group: Common Questions

Does L-Ornithine-L-Aspartate by Allergy Research Group interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Ornithine-L-Aspartate. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Ornithine-L-Aspartate contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does L-Ornithine-L-Aspartate do?
It helps your body remove ammonia, a toxic waste product that builds up when the liver isn't working properly. High ammonia levels can damage your brain and cause confusion and difficulty thinking — a condition called hepatic encephalopathy.
Is it proven to work?
It's rated possibly effective for hepatic encephalopathy, a serious liver-related brain condition. For other uses like athletic performance, muscle wasting, or wound healing, we don't have enough reliable evidence to say whether it works.
Can I take it if I'm pregnant or breastfeeding?
Safety hasn't been established in pregnancy, so it's best avoided unless your doctor tells you otherwise. If you're breastfeeding, there isn't enough safety data either — talk with your doctor or pharmacist before using it.
What side effects might I have?
When taken by mouth, it's generally well tolerated. If given intravenously (which is typical in medical settings), the most common side effects are cough, muscle cramps, nausea, and vomiting — slowing the infusion can help with nausea.
Should I use this on my own for liver problems?
No — this is meant to be used under medical supervision for serious liver disease. Don't self-treat without your doctor's guidance and monitoring.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Ornithine-L-Aspartate is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Ornithine-L-Aspartate label
Go deeper

The Full Monographs Behind L-Ornithine-L-Aspartate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Ornithine-L-Aspartate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-ornithine-l-aspartate 3 references
  1. Ahmad, I., Khan, A. A., Alam, A., Dilshad, A., Butt, A. K., Shafqat, F., Malik, K., and Sarwar, S. L-ornithine-L-aspartate infusion efficacy in hepatic encephalopathy. J.Coll.Physicians Surg.Pak. 2008;18(11):684-687.
  2. Waghray A, Waghray N, Mullen K. Management of covert hepatic encephalopathy. J Clin Exp Hepatol 2015;5:S75-81. PubMed
  3. Pérez Hernández JL, Higuera de la Tijera F, Serralde-Zúñiga AE, Abdo Francis JM. Critical analysis of studies evaluating the efficacy of infusion of L-ornithine L-aspartate in clinical hepatic encephalopathy in patients with liver failure. Ann Hepatol 201

See these in context on the L-ornithine-l-aspartate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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