Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Lechita Ingredients & Drug Interactions

by Legendairy Milk

Lechita label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lechita against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lechita is a dietary supplement by Legendairy Milk with 4 active ingredients. Its ingredients are commonly taken for digestive upset and bloating, infant colic, menstrual cramps.Based on those ingredients, 1,065 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fennel, Caraway, Anise. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lechita by Legendairy Milk

Ask about any prescription or over-the-counter medication and we check it for interactions with Lechita by Legendairy Milk — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lechita by Legendairy Milk

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,060 mg) without saying how much of each component you get.

Lechita contains 4 active ingredients: fennel, organic goat's rue, caraway, and anise—all presented as a proprietary blend. Fennel and caraway are traditional digestive herbs, while anise is also used for digestive comfort and has a long food history.

Goat's rue has been traditionally used to support milk supply in nursing mothers, which is the intended purpose of this product. The capsule itself contains pullulan as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support natural milk production.
  • We looked for evidence on: Lactation, breast milk supply, milk production, galactagogue.
  • The closest evidence on file: Goat's Rue is rated "Insufficient Reliable Evidence To Rate" for Lactation (Natural Medicines).
  • Also on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Lactation.
  • Also on file: Anise is rated "Insufficient Reliable Evidence To Rate" for Lactation.

For the main claim here—lactation support—we hold only insufficient evidence to rate goat's rue in our data. Fennel is possibly effective for painful periods (dysmenorrhea), but the evidence for its other uses (anxiety, bronchitis, cough) is insufficient.

Caraway and anise both show insufficient evidence for most of their traditional uses; caraway is rated possibly effective for indigestion (dyspepsia), while all of anise's listed uses lack reliable evidence in the data we hold.

The evidence, ingredient by ingredient Fennel Goat's Rue Caraway Anise

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fennel, caraway, and anise are generally well tolerated in food amounts but warrant caution at medicinal or concentrated doses. Fennel should be avoided in concentrated or medicinal amounts during pregnancy due to limited safety data and possible hormone-like effects; the same applies to caraway and anise.

Small amounts in food are likely fine, but medicinal doses and essential oils are less studied during breastfeeding. Goat's rue should be avoided during pregnancy due to insufficient safety data, though it is traditionally used for milk supply during lactation—use only with professional guidance.

Adverse effects are generally mild: fennel and anise may cause gastrointestinal discomfort, photosensitivity, or allergic reactions in sensitive people; caraway in combination with peppermint has been reported to cause burning, belching, nausea, or vomiting. Allergic reactions including anaphylaxis are rare but possible with anise.

Fennel and caraway seeds have been reported to trigger asthma or bronchial symptoms in rare cases.

Side effects, ingredient by ingredient Fennel Goat's Rue Caraway Anise

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Goat's Rue, Caraway, Fennel, Anise.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,066 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Lechita, double-check your medications, especially if you take blood thinners or antiplatelet drugs (Moderate concern from fennel and goat's rue), birth control or hormone therapy (Moderate concern from fennel and anise), diabetes medications (Moderate concern from caraway and anise), water pills or lithium (Moderate concern from caraway), sedative drugs like diazepam or CNS depressants (Moderate concern from caraway and anise), the antibiotic ciprofloxacin (Cipro), or antidepressants like fluoxetine (Prozac) or imipramine (Tofranil). Use the medication checker on this page to confirm your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for nursing mothers looking to support milk supply. If you take blood thinners, birth control, hormone therapy, diabetes medications, water pills, lithium, sedatives, or certain antidepressants, check your exact medications with our tool before starting.

Talk with your pharmacist or doctor about whether this product is right for you, especially if you're pregnant or have allergies to herbs in the carrot or parsley family.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lechita, straight from the product label.

Brand Legendairy Milk
Barcode (UPC) 853792007104
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 319886
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Kosher, Women (not pregnant or lactating), Organic, Lactating
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lechita by Legendairy Milk, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
853792007104
IngredientAmount% DV
Proprietary Blend1060 mg--
Fennel0 NP--
organic Goat's Rue0 NP--
Caraway0 NP--
Anise0 NP--

Other ingredients: Pullulan

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Lechita is designed to support your natural milk production with ingredients that have been traditionally used amongst lactating women all around the world.

OU (Kosher)

H Halal

Contains fennel seed, anise seed and other supportive herbs

General Statements

Fennel fun fact Flasks of fennel tea are common in German postpartum floors.

Share your journey! @legenadairymilk Facebook Instagram TikTok Learn why we're Fenugreek free at www.fenugreekfree.com Meet the stud... And the duo.

10-day supply

Formulation

Certified Vegan Vegan.org

Non GMO Project Verified nongmoproject.org Fenugreek free Sugar free No additives No fillers

Promotes milk flow Digestive support for mom/baby

USDA Organic

Certified organic by QAI

Seals/Symbols

Certified Vegan Vegan.org OU (Kosher) H Halal Non GMO Project Verified nongmoproject.org Made in the USA with domestic and imported ingredients

USDA Organic

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules 3 times daily. Take with food and drink to thirst.

Precautions

Heads up mama! Not for use during pregnancy.

Keep away from children.

May lower blood sugar - if you are diabetic or hypoglycemic, consult with your doctor before use.

Hypersensitivity, such as allergy, may occur; in which case, discontinue use.

Take with food and stay hydrated.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lechita by Legendairy Milk label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lechita label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lechita by Legendairy Milk

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1060 mg per serving

Other (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lechita by Legendairy Milk Drug Interactions

Want to check YOUR meds against Lechita?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,065Drugs
1,046 Moderate 19 Minor

Ingredients driving the most interactions

Fennel 740
Caraway 413
Anise 245
organic Goat's Rue 122

Individual Drug Interactions

The ingredients in Lechita interact with 1,065 drugs. Click any drug to see the details.

4 of the 4 ingredients in Lechita interact with drugs. Each result below shows which ingredient is responsible. Fennel Caraway Anise organic Goat's Rue

Each ingredient & the kinds of drugs it affects

For each ingredient in Lechita with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel full monograph & interactions

Caraway7 drug types · 413 drugs

Antidiabetes Drugs

Theoretically, caraway might increase the risk of hypoglycemia when used with antidiabetes drugs.
Animal research suggests that caraway can reduce blood glucose levels. Monitor blood glucose levels closely. Medication dose adjustments may be necessary.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, caraway might increase the effects and adverse effects of CNS depressants.
Animal research suggests that (S)-(+)-carvone, a major constituent of caraway seed extract, has sedative effects.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, caraway might increase the risk of hypokalemia when used with diuretics that deplete potassium.
Animal research suggests that a single dose of caraway fruit extract can promote diuresis and increase the urinary excretion of sodium and potassium. However, sub-chronic use of caraway fruit extract does not seem to significantly increase potassium excretion, although urine output continues to be increased for up to 6 days.

Likelihood Possible Evidence D
Lithium

Theoretically, caraway might reduce excretion and increase levels of lithium due to diuretic effects.
Animal research suggests that caraway fruit extract has diuretic properties.

Likelihood Possible Evidence D
Isoniazid

Theoretically, caraway might increase the effects and adverse effects of isoniazid.
Animal research suggests that a specific fraction of caraway seed extract (CC-1a) can increase plasma levels of isoniazid when administered concomitantly. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Pyrazinamide

Theoretically, caraway might increase the effects and adverse effects of pyrazinamide.
Animal research suggests that a specific fraction of caraway seed extract (CC-1a) can increase plasma levels of pyrazinamide when administered concomitantly. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Rifampin (Rifadin)

Theoretically, caraway might increase the effects and adverse effects of rifampin.
Animal research suggests that a specific fraction of caraway seed extract (CC-1a) can increase plasma levels of rifampin when administered concomitantly. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Caraway full monograph & interactions

Anise11 drug types · 245 drugs

Antidiabetes Drugs

Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A small clinical study shows that anise seed powder decreases fasting blood glucose levels by 36% when compared to baseline.

Likelihood Possible Evidence B
Caffeine

Theoretically, anise oil might decrease the efficacy of caffeine.
Animal research shows that taking anise oil with caffeine decreases the bioavailability of caffeine. Whether this interaction will occur in humans is unclear.

Likelihood Possible Evidence D
Codeine

Theoretically, anise oil might increase the effects and adverse effects of codeine.
Animal research shows that anise oil increases the analgesic effects of codeine, possibly by inducing its phase I metabolism and increasing conversion to morphine. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, anise might interfere with contraceptive drug therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Diazepam (Valium)

Theoretically, anise oil might increase the effects and adverse effects of diazepam.
Animal research shows that taking anise oil with diazepam increases the motor impairment associated with diazepam, possibly by inhibiting its breakdown by cytochrome P450 3A4. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Estrogens

Theoretically, anise might interfere with estrogen-based hormone replacement therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Fluoxetine (Prozac)

Theoretically, anise oil might decrease the efficacy of fluoxetine.
Animal research shows that taking anise oil with fluoxetine reduces the antidepressant effects of fluoxetine, possibly by promoting its breakdown by cytochrome P450 2D6. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Imipramine (Tofranil)

Theoretically, anise oil might decrease the efficacy of imipramine.
Animal research shows that taking anise oil with imipramine reduces the antidepressant effects of imipramine, possibly by promoting its breakdown by cytochrome P450 2D6. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, anise oil might increase the effects and adverse effects of midazolam.
Animal research shows that taking anise oil with midazolam increases the motor impairment associated with midazolam, possibly by inhibiting its breakdown by cytochrome P450 3A4. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, anise might interfere with tamoxifen therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Animal research shows that taking anise oil with acetaminophen decreases peak plasma levels of acetaminophen but does not reduce overall bioavailability. Whether this interaction will occur in humans is unclear.

Likelihood Possible Evidence D
Anise full monograph & interactions

organic Goat's Rue1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Laboratory research suggests that goat's rue extract can inhibit platelet aggregation. Theoretically, goat's rue might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
organic Goat's Rue full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lechita, from the product label.

Legendairy Milk

See all Legendairy Milk products
Name
Legendairy Milk, LLC
Street Address
1007 S. Heatherwilde Blvd., Suite 100
City
Pflugerville
State
Texas
ZipCode
78660
Web Address
www.legendairymilk.com
Pharmacist Counseling Corner

Lechita by Legendairy Milk: Common Questions

Does Lechita by Legendairy Milk interact with any medications?
Yes. Based on its ingredients, Lechita has a known interaction with 1,065 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lechita contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while breastfeeding?
Goat's rue is traditionally used to support milk supply during lactation, but it should only be used with professional guidance because quality and safety data vary. Food amounts of fennel, caraway, and anise are likely safe while breastfeeding, but medicinal doses and concentrated forms are not well studied—talk with your doctor or pharmacist about what's right for you.
Can I take this if I'm pregnant?
Fennel, caraway, and anise should be avoided in medicinal or concentrated amounts during pregnancy due to limited safety data and possible hormone-like effects; food amounts are likely fine but data are sparse. Goat's rue is not well studied in pregnancy and is best avoided. Talk with your doctor before use.
What is goat's rue supposed to do?
Goat's rue is traditionally used to support milk supply in nursing mothers, which is the main purpose of this product. However, the evidence to confirm this is insufficient in the data we hold.
Are there side effects I should watch for?
Most side effects are mild—gastrointestinal discomfort, photosensitivity, or mild allergic reactions in sensitive people. Allergic reactions including anaphylaxis are rare but possible. Fennel and caraway seeds have been reported to trigger asthma in rare cases. If you have a history of allergies or asthma, tell your pharmacist before taking this.
Does caraway work for indigestion?
Caraway is rated possibly effective for indigestion (dyspepsia) in our data. The other uses listed for caraway, fennel, and anise lack reliable evidence to support them.
Can I take this with my other supplements or herbs?
The data on file covers interactions with medications, not other supplements or herbs. Talk with your pharmacist about any other supplements or herbal products you're taking alongside Lechita.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lechita label
Go deeper

The Full Monographs Behind Lechita’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Goat's Rue

Interacts with 122 drugs

Goat's rue is a traditional herb most often used by nursing parents to try to increase milk supply, and it has a historical link to diabetes research. Solid human evidence for either use is...

Read the full Goat's Rue monograph → Herb & supplement monograph

Caraway

Interacts with 413 drugs

Caraway is a common cooking spice that has long been used to ease gas, bloating, and indigestion. Some evidence suggests caraway oil—often combined with peppermint oil—may help with indigest...

Read the full Caraway monograph → Herb & supplement monograph

Anise

Interacts with 245 drugs

Anise is a fragrant, licorice-flavored seed used for centuries to ease digestion and soothe coughs. Most of its health claims are based on tradition and small or laboratory studies rather th...

Read the full Anise monograph →
Sources

Sources & How We Checked

Lechita's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 46 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
  4. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  5. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  6. Rosti L, Nardini A, Bettinelli ME, Rosti D. Toxic effects of a herbal tea mixture in two newborns. Acta Paediatrica 1994;83:683. PubMed
  7. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  8. Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol.Res 2007;56(3):254-260. PubMed
  9. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
  10. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  11. Subehan, Zaidi, S. F., Kadota, S., and Tezuka, Y. Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. J Agric.Food Chem. 12-12-2007;55(25):101 PubMed
  12. LEVY, S. B. Bronchial asthma due to ingestion of fennel and fennel seed. Ann.Allergy 1948;6(4):415.
  13. Ottolenghi, A., De Chiara, A., Arrigoni, S., Terracciano, L., and De Amici, M. [Diagnosis of food allergy caused by fruit and vegetables in children with atopic dermatitis]. Pediatr Med Chir 1995;17(6):525-530.
  14. Trabace L, Tucci P, Ciuffreda L, et al. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. J Ethnopharmacol. 2015;174:396-402. PubMed
  15. Denaxa D, Arkwright PD. Fennel as a cause of immediate hypersensitivity to toothpaste. Ann Allergy Asthma Immunol. 2020;125(1):99-100. PubMed
  16. Lee HW, Ang L, Lee MS, Alimoradi Z, Kim E. Fennel for reducing pain in primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Nutrients 2020;12(11):3438. PubMed
  17. Mathew T, John SK, Javali M, Vasireddy M, Nadig R, Sarma GRK. Substance use related cluster headache: A case series. Headache 2022;62(7):908-910. PubMed

See these in context on the Fennel monograph →

Goat's Rue 6 references
  1. Atanasov AT. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Med Plants 1995;3:71-6.
  2. Atanasov, A. T. and Spasov, V. Inhibiting effect of desalted extract from Galega officinalis L. on platelet aggregation. Folia Med.(Plovdiv.) 1999;41(1):46-50.
  3. Atanasov, A. T. and Spasov, V. Inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. J.Ethnopharmacol. 2000;69(3):235-240. PubMed
  4. Atanasov, A. T. and Tchorbanov, B. Anti-platelet fraction from Galega officinalis L. inhibits platelet aggregation. J.Med.Food 2002;5(4):229-234.
  5. Atanasov, A. T. and Tchorbanov, B. J. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. J Herbs Spices Medicinal Plant 2002;10(2):63-71.
  6. Salatino S, Giacomelli L, Carnevali I, Giacomelli E. The role of natural galactagogues during breast feeding: focus on a Galega officinalis based food supplement. Minerva Pediatr. 2017 Dec;69(6):531-537. PubMed

See these in context on the Goat's Rue monograph →

Caraway 11 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
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See these in context on the Caraway monograph →

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See these in context on the Anise monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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