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Dietary supplement

Liver Plus 660 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Liver Plus 660 mg label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Liver Plus 660 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Liver Plus 660 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for anemia and low iron, vitamin b12 support, general energy and fatigue.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Beef Liver. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Liver Plus 660 mg by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Liver Plus 660 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Liver Plus 660 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Liver Plus contains one active ingredient: beef liver extract at 660 mg per tablet. Beef liver is nutrient-dense, containing iron, B vitamins, and other compounds.

The tablet also includes inactive ingredients—stearic acid, croscarmellose sodium, silicon dioxide, and pharmaceutical glaze—which help form and hold the tablet together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Liver Extract product and its label doesn't state a use — see Liver Extract's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for beef liver extract is limited. For chronic fatigue syndrome (low energy and ongoing tiredness), the data suggests it's possibly ineffective.

For hepatitis C (a liver virus infection), we don't have enough reliable evidence to rate whether it works. If you're considering this product for either of these conditions, talk with your doctor about whether it makes sense for you.

The evidence, ingredient by ingredient Liver Extract

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

No adverse reactions have been reported in people taking beef liver extract, though a thorough safety review hasn't been done. There is concern about contamination—since liver extract comes from raw animal livers from slaughterhouses, there's a theoretical risk of exposure to sick or diseased tissue.

Additionally, there's concern about bovine spongiform encephalopathy (BSE, also called mad cow disease) in beef from certain countries where the disease has been reported, including Great Britain, France, The Netherlands, Portugal, Luxembourg, Ireland, Switzerland, Oman, and Belgium. To date, no cases of BSE have been traced to contaminated liver extract products sold to consumers.

Beef liver is also very high in vitamin A, which can harm a developing baby during pregnancy, so avoid this product unless your doctor advises otherwise. Safety during breastfeeding hasn't been well studied—check with your doctor before using.

Side effects, ingredient by ingredient Liver Extract

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Liver Extract.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take warfarin (Coumadin) or any blood thinner, or if you take iron supplements or iron-containing medications before starting Liver Plus. Altogether, these interactions span 3 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Beef liver extract may appeal to you if you're looking for a whole-food source of iron and B vitamins, but the evidence it helps chronic fatigue or hepatitis C is weak or absent. If you take warfarin or iron supplements, this product needs a medication check first.

Pregnant women should avoid it due to high vitamin A content.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Liver Plus 660 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536029693
Net contents 240 Tablet(s)
Market status On market
Date entered into DSLD Aug 26, 2014
DSLD ID 36311
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Liver Plus 660 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
766536029693
IngredientAmount% DV
Beef Liver660 mg--

Other ingredients: Stearic Acid, Croscarmellose Sodium, Silicon Dioxide, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

specialty

{tablet} actual size

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

{QRC} learn more at vsquality.net

FDA Statement of Identity

dietary supplement

Formulation

gluten free dairy free soy free nut free

Does not contain: Yeast, Corn, Wheat, Gluten, Sugar, Salt, Soy, Starch, Dairy, Citrus, Fish, Preservatives, Artificial Colors or Flavors.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

STORE IN A COOL, DRY PLACE.

Precautions

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT Do not use if outer seal is broken or missing.

WARNING: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take one (1) tablet, up to six (6) times daily, preferably with meals.

General

Item No. VS-2969 1967264 EO 1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Liver Plus 660 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Liver Plus 660 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Liver Plus 660 mg by The Vitamin Shoppe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Beef Liver

Interacts with
3 drugs
660 mg per serving

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once...

Beef Liver monograph & interactions

Other (inactive) ingredients: Stearic Acid, Croscarmellose Sodium, Silicon Dioxide, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Liver Plus 660 mg by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Liver Plus 660 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Beef Liver 3

Individual Drug Interactions

The ingredients in Liver Plus 660 mg interact with 3 drugs. Click any drug to see the details.

1 of the 1 ingredient in Liver Plus 660 mg interact with drugs. Each result below shows which ingredient is responsible. Beef Liver

Each ingredient & the kinds of drugs it affects

For each ingredient in Liver Plus 660 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Beef Liver2 drug types · 3 drugs

Iron

Liver extract can contain heme iron. Taking liver extract with iron-containing medications or supplements may increase total iron intake and could increase the risk of gastrointestinal adverse effects or excessive iron accumulation. The risk is greater with high doses, prolonged use, or in individuals with hemochromatosis or another iron-overload disorder. Review the iron content of the liver extract and the total elemental iron dose. Avoid unnecessary duplicate iron supplementation and consider monitoring ferritin and transferrin saturation when clinically appropriate.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Liver extract products may contain small and variable amounts of vitamin K. Theoretically, starting, stopping, or substantially changing the amount of liver extract used could reduce the anticoagulant effect of warfarin and lower the INR. However, this interaction has not been directly studied or reported in humans, and the vitamin K content of liver extract products is generally not standardized. Consider monitoring the INR after a meaningful change in liver extract use.

Likelihood Possible Evidence C
Beef Liver full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Liver Plus 660 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Liver Plus 660 mg by The Vitamin Shoppe: Common Questions

Does Liver Plus 660 mg by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Liver Plus 660 mg has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Liver Plus 660 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is beef liver extract the same as eating liver?
It's concentrated extract from beef liver, so it delivers much more of the nutrients—including iron and vitamin A—than a typical serving of food. That's why the cautions about high iron and vitamin A apply here in a way they wouldn't to a normal meal.
Will this product help my chronic fatigue?
The evidence suggests it's probably not effective for chronic fatigue syndrome. If you're dealing with low energy, talk with your doctor about other approaches that have better evidence behind them.
Can I take this if I'm pregnant?
No. Beef liver extract is very high in vitamin A, which can harm a developing baby. Avoid it unless your doctor specifically tells you it's safe for you.
What's the concern about BSE (mad cow disease)?
Some beef liver extract comes from countries where mad cow disease has been found in cattle. There's a theoretical risk that contaminated tissue could end up in the extract, though no human cases have ever been traced to liver extract supplements. If you're concerned, choose a product from a country where BSE has not been reported.
Why do I need to check with my pharmacist if I take warfarin?
Beef liver contains vitamin K, which naturally reduces how well warfarin (a blood thinner) works. The amount of vitamin K varies between batches and products, so if you start, stop, or change how much of this product you use, it could affect your blood thickness and INR reading. Your pharmacist or doctor needs to know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Liver Plus 660 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Liver Plus 660 mg label
Go deeper

The Full Monographs Behind Liver Plus 660 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Liver Extract

Interacts with 3 drugs

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once used to treat certain anemias before pu...

Read the full Liver Extract monograph →
Sources

Sources & How We Checked

Liver Plus 660 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Liver Extract 4 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
  3. Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
  4. Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed

See these in context on the Liver Extract monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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