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Dietary supplement

Apple Cider Vinegar with Apple Pectin Ingredients & Drug Interactions

by The Vitamin Shoppe

Apple Cider Vinegar with Apple Pectin label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Apple Cider Vinegar with Apple Pectin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Apple Cider Vinegar with Apple Pectin is a dietary supplement by The Vitamin Shoppe with 2 active ingredients. Its ingredients are commonly taken for diarrhea relief, constipation and digestive health, cholesterol support.Based on those ingredients, 184 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Apple Cider Vinegar powder, Apple Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Apple Cider Vinegar with Apple Pectin by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Apple Cider Vinegar with Apple Pectin by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Apple Cider Vinegar with Apple Pectin by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Apple pectin is a soluble fiber extracted from apples that may help with cholesterol levels.

Apple cider vinegar powder is a concentrated form of vinegar made from apples. The tablet also contains several inactive ingredients — microcrystalline cellulose, dicalcium phosphate, stearic acid, magnesium stearate, and an aqueous coating — which are fillers and binders that help form and protect the tablet.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“Digestive support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Pectin) (Natural Medicines).

Apple pectin is possibly effective for high cholesterol. The evidence for apple cider vinegar is less established.

For prediabetes (impaired glucose tolerance) and radiation exposure, the data we hold shows insufficient reliable evidence to rate either ingredient. For apple cider vinegar's other proposed uses — acne, athletic performance, cognitive function, dental plaque, and depression — evidence isn't established in our data.

The evidence, ingredient by ingredient Pectin Apple Cider Vinegar

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pectin from food and typical supplement amounts is generally well tolerated. The most common side effects are mild: diarrhea, gas, loose stools, and mild cramps.

Rarely, sensitive individuals may have allergic reactions, including anaphylaxis. Apple cider vinegar in food amounts is well tolerated, but large doses or long-term use may pose risks.

Concentrated or undiluted vinegar can cause harm. Long-term overuse has been linked to low potassium (hypokalemia), elevated renin, and osteoporosis.

For pregnancy, pectin safety data at supplement doses is limited — talk with your doctor. Apple cider vinegar safety data in pregnancy and breastfeeding is not on file, so check with your doctor or pharmacist before use if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Pectin Apple Cider Vinegar

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Pectin, Apple Cider Vinegar.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications.
  • For scale: 184 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take digoxin (a heart medication), tetracycline antibiotics, lovastatin, diuretics (water pills), insulin, or other antidiabetes drugs. Digoxin and diuretics carry the highest concern (Moderate severity), but all these drug types have documented interactions with one or both ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with cholesterol if you're looking for a pectin source, but you'll want to clear it with your doctor or pharmacist first — especially if you take digoxin, tetracycline antibiotics, lovastatin, diuretics, insulin, or other diabetes medications. The apple cider vinegar component raises safety concerns with long-term use at high doses.

Talk it over with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Apple Cider Vinegar with Apple Pectin, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536012312
Net contents 300 Tablet(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 221501
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Apple Cider Vinegar with Apple Pectin by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
766536012312
IngredientAmount% DV
Apple Pectin27 mg--
Apple Cider Vinegar powder108 mg--

Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Aqueous Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Apple Cider Vinegar With Apple Pectin a fermented superfood

Formulation

Digestive support

Gluten-free Dairy-free Soy-free Nut-free Does Not Contain: Gluten, sugar, salt, preservatives, artificial colors or flavors.

General Statements

Specialty

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Quality Promise Tested & Trusted

Suggested/Recommended/Usage/Directions

Directions: Take one (1) tablet up to two (2) times daily, preferably with meals.

Precautions

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication, or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Apple Cider Vinegar with Apple Pectin by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Apple Cider Vinegar with Apple Pectin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Apple Cider Vinegar with Apple Pectin by The Vitamin Shoppe

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Apple Pectin

Interacts with
23 drugs
27 mg per serving

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...

Apple Pectin monograph & interactions

Apple Cider Vinegar powder

Interacts with
162 drugs
108 mg per serving Form: Acetic Acid

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Apple Cider Vinegar powder monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Aqueous Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Apple Cider Vinegar with Apple Pectin by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Apple Cider Vinegar with Apple Pectin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
184Drugs
111 Moderate 73 Minor

Ingredients driving the most interactions

Apple Cider Vinegar powder 162
Apple Pectin 23

Individual Drug Interactions

The ingredients in Apple Cider Vinegar with Apple Pectin interact with 184 drugs. Click any drug to see the details.

2 of the 2 ingredients in Apple Cider Vinegar with Apple Pectin interact with drugs. Each result below shows which ingredient is responsible. Apple Cider Vinegar powder Apple Pectin

Each ingredient & the kinds of drugs it affects

For each ingredient in Apple Cider Vinegar with Apple Pectin with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Apple Cider Vinegar powder4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar powder full monograph & interactions

Apple Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Apple Pectin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Apple Cider Vinegar with Apple Pectin, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
The Vitamin Shoppe
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-866-293-3367
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Apple Cider Vinegar with Apple Pectin by The Vitamin Shoppe: Common Questions

Does Apple Cider Vinegar with Apple Pectin by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Apple Cider Vinegar with Apple Pectin has a known interaction with 184 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Apple Cider Vinegar with Apple Pectin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on digoxin?
No — both ingredients in this product interact with digoxin in ways that could reduce how well it works or increase the risk of toxicity. Talk with your doctor or pharmacist about whether this product is right for you.
What are the most common side effects of this product?
From the pectin, most people experience mild gastrointestinal effects: diarrhea, gas, loose stools, or mild cramps. Serious allergic reactions, including anaphylaxis, are rare but can happen in sensitive individuals.
Is apple pectin really effective for cholesterol?
The evidence shows it's possibly effective for high cholesterol. Apple cider vinegar, though, doesn't have enough evidence to rate for any of its proposed uses in our data.
Can I use this if I'm pregnant or breastfeeding?
Pectin at typical food amounts is likely safe, but supplement-dose safety in pregnancy and breastfeeding hasn't been well studied — check with your doctor for personalized advice. For apple cider vinegar, we don't have safety data on file for pregnancy or breastfeeding, so talk it over with your healthcare provider.
Is this product safe to take long-term?
Pectin is generally well tolerated. Apple cider vinegar, though, may not be safe in large amounts or long-term use — the facts show rare but serious effects like low potassium, elevated renin levels, and osteoporosis with chronic overuse. Your doctor or pharmacist can advise on how much is safe for you.
What does the apple cider vinegar in this product do?
The evidence in our data doesn't establish that apple cider vinegar works for any of its proposed uses — acne, athletic performance, cognitive function, dental plaque, and depression all lack reliable evidence to rate. Talk with your doctor about whether this ingredient makes sense for your needs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Apple Cider Vinegar with Apple Pectin is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Apple Cider Vinegar with Apple Pectin label
Go deeper

The Full Monographs Behind Apple Cider Vinegar with Apple Pectin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph → Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph →
Sources

Sources & How We Checked

Apple Cider Vinegar with Apple Pectin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
  9. Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther 2021;21(1):179. PubMed
  10. Feise NK, Johnston CS. Commercial vinegar tablets do not display the same physiological benefits for managing postprandial glucose concentrations as liquid vinegar. J Nutr Metab 2020;2020:9098739. PubMed
  11. Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized contro

See these in context on the Apple Cider Vinegar monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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