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Dietary supplement

Longjack (Tongkat Ali) 100:1 Ingredients & Drug Interactions

by PureBulk.com

Longjack (Tongkat Ali) 100:1 label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Longjack (Tongkat Ali) 100:1 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Longjack (Tongkat Ali) 100:1 is a dietary supplement by PureBulk.com with 1 active ingredient. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Longjack. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Longjack (Tongkat Ali) 100:1 by PureBulk.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Longjack (Tongkat Ali) 100:1 by PureBulk.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Longjack (Tongkat Ali) 100:1 by PureBulk.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Longjack (also called Tongkat Ali), supplied as a 100:1 extract — meaning the powder is 100 times more concentrated than the raw plant root. The only other ingredient is maltodextrin, an inactive filler used to make the powder easier to handle.

Longjack comes from the Eurycoma longifolia plant, native to Southeast Asia. Traditionally it's been used to support energy and sexual function, though the scientific evidence for some of these uses is still developing.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Eurycoma Longifolia's overall clinical evidence instead.

Moderate

Some clinical evidence supports Eurycoma Longifolia for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sexual desire — rated "Possibly Effective" (Natural Medicines).

The evidence for Longjack is mixed and depends on what you're using it for. The data shows it's possibly effective for sexual desire, but possibly ineffective for athletic performance.

For back pain, osteoporosis, and diabetes, we don't have enough reliable evidence to say whether it works or doesn't — the research just isn't there yet in the sources we hold.

The evidence, ingredient by ingredient Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Longjack is generally tolerated in short-term studies, but we don't have solid long-term safety data or reliable information about product quality across different brands. The supplement may increase testosterone levels, and if levels go too high, there's a risk of testosterone-related side effects including acne, insulin resistance, and liver toxicity.

Because of possible hormonal effects and limited safety information, the data advises against using Longjack during pregnancy or while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Longjack, double-check it with your doctor or pharmacist if you're on propranolol (Inderal) or any other beta-blocker — the interaction is Moderate and can reduce how well the blood pressure medication works. Also flag any medications that your liver breaks down, including many antidepressants, blood thinners, and other common drugs, because Longjack may raise their levels.

If you're on testosterone replacement therapy or other hormonal medications, confirm it's okay to add this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Longjack might be worth considering if you're interested in sexual desire support, but it's not established for athletic performance or several other uses. Because it interacts with a significant number of medications — especially propranolol and drugs your liver processes — and may raise testosterone levels, you'll want to check with your own doctor or pharmacist before starting it, especially if you take heart or blood pressure medications, or any prescription drugs metabolized by your liver.

Pregnant people and those breastfeeding should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Longjack (Tongkat Ali) 100:1, straight from the product label.

Brand PureBulk.com
Net contents 100 g; 3.53 oz.
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 23155
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Longjack (Tongkat Ali) 100:1 by PureBulk.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
80 mg
Maximum serving Sizes:
80 mg
Servings per container
1250
IngredientAmount% DV
Longjack80 mg--

Other ingredients: Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Derived from Eurycoma Longifolia tree root

US Standard Measuring Spoons Spoon Size (level) milligrams 1/64 teaspoon 50 1/32 teaspoon 100 1/16 teaspoon 200

Storage

Storage: Keep dry, cool & dark

Formulation

Free of: soy, dairy, yeast and gluten.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 80 mg (scant 1/32 tsp) twice daily with meals, or as directed by physician.

Precautions

Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult your physician before use.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Longjack (Tongkat Ali) 100:1 by PureBulk.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Longjack (Tongkat Ali) 100:1 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Longjack (Tongkat Ali) 100:1 by PureBulk.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size80 mg Dosage formPowder Servings per container1250 Amounts shown are per serving.

Longjack

Interacts with
248 drugs
80 mg per serving Form: Eurycoma longifolia extract

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Longjack monograph & interactions

Other (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Longjack (Tongkat Ali) 100:1 by PureBulk.com Drug Interactions

Want to check YOUR meds against Longjack (Tongkat Ali) 100:1?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Longjack 248

Individual Drug Interactions

The ingredients in Longjack (Tongkat Ali) 100:1 interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Longjack (Tongkat Ali) 100:1 interact with drugs. Each result below shows which ingredient is responsible. Longjack

Each ingredient & the kinds of drugs it affects

For each ingredient in Longjack (Tongkat Ali) 100:1 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Longjack5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Longjack full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Longjack (Tongkat Ali) 100:1, from the product label.

PureBulk.com

See all PureBulk.com products
Name
PureBulk.com
City
Roseburg
State
OR
ZipCode
97471
Phone Number
(541) 679-1500
Web Address
PureBulk.com
Pharmacist Counseling Corner

Longjack (Tongkat Ali) 100:1 by PureBulk.com: Common Questions

Does Longjack (Tongkat Ali) 100:1 by PureBulk.com interact with any medications?
Yes. Based on its ingredients, Longjack (Tongkat Ali) 100:1 has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Longjack (Tongkat Ali) 100:1 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Longjack actually work for sexual desire?
The data shows it's possibly effective for sexual desire, which means there's some evidence supporting it but the research isn't definitive. Results can vary from person to person, and it's worth talking with your doctor about whether it might help in your situation.
Can I take this while pregnant or breastfeeding?
No — the safety data advises against Longjack during pregnancy because of possible hormonal effects and limited safety information. If you're breastfeeding, there's not enough reliable safety data, so it's best to avoid it. Talk with your doctor or pharmacist about safer options if you're in either situation.
What are the possible side effects?
If Longjack raises your testosterone levels too high, you might experience testosterone-related side effects like acne, insulin resistance, and liver problems. Short-term studies show it's generally tolerated, but long-term safety data is limited, so we don't know all the risks of using it over time.
Is this the same as Tongkat Ali?
Yes — Longjack and Tongkat Ali are the same plant (Eurycoma longifolia). This product is a 100:1 extract, meaning it's concentrated 100 times stronger than the raw root, so you're getting a potent dose in each serving.
What does the '100:1' mean?
The 100:1 ratio means the powder is made by concentrating the plant material — it takes 100 pounds of raw root to make 1 pound of this extract. It's a way to make Longjack more potent and easier to dose as a powder.
Will this interfere with my blood pressure medication?
Possibly — if you take propranolol (Inderal), Longjack can lower the drug's levels in your blood by about 29%, which may reduce how well it controls your blood pressure. Even if you're on a different blood pressure medication, check with your pharmacist first, because Longjack affects how your liver processes several drug types.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Longjack (Tongkat Ali) 100:1 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Longjack (Tongkat Ali) 100:1 label
Go deeper

The Full Monographs Behind Longjack (Tongkat Ali) 100:1’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Longjack (Tongkat Ali) 100:1's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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